Recombinant multi-species HXK4/ GCK/ FGQTL3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: GCK, gene name: GCK, also named as FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2. This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T87166-Ag-1	Human GCK protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T87166-Ag-1	Rat GCK protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T87166-Ag-1	Mouse GCK protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T87166-Ag-1	Cynomolgus/ Rhesus macaque GCK protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T87166-Ag-1	Feline GCK protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T87166-Ag-1	Canine GCK protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T87166-Ag-1	Bovine GCK protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T87166-Ag-1	Equine GCK protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T87166-Ag, GM-Tg-rg-T87166-Ag, GM-Tg-mg-T87166-Ag, GM-Tg-cynog-T87166-Ag, GM-Tg-felg-T87166-Ag, GM-Tg-cang-T87166-Ag, GM-Tg-bovg-T87166-Ag, GM-Tg-equg-T87166-Ag-1
Products Name	GCK protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	GCK
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCK protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.