Recombinant multi-species DNMT1/ ADCADN/ AIM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to DNMT1/DNMT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNMT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: DNMT1, gene name: DNMT1, also named as ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI. This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T88304-Ag-1Human DNMT1 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T88304-Ag-1Rat DNMT1 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T88304-Ag-1Mouse DNMT1 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T88304-Ag-1Cynomolgus/ Rhesus macaque DNMT1 proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T88304-Ag-1Feline DNMT1 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T88304-Ag-1Canine DNMT1 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T88304-Ag-1Bovine DNMT1 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T88304-Ag-1Equine DNMT1 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T88304-Ag, GM-Tg-rg-T88304-Ag, GM-Tg-mg-T88304-Ag, GM-Tg-cynog-T88304-Ag,
GM-Tg-felg-T88304-Ag, GM-Tg-cang-T88304-Ag, GM-Tg-bovg-T88304-Ag, GM-Tg-equg-T88304-Ag-1
Products Name DNMT1 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameDNMT1
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNMT1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.