Recombinant multi-species IL12B/ CLMF/ CLMF2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL12B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: IL12B, gene name: IL12B, also named as CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2. This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T95385-Ag-1	Human IL12B protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T95385-Ag-1	Rat IL12B protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T95385-Ag-1	Mouse IL12B protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T95385-Ag-1	Cynomolgus/ Rhesus macaque IL12B protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T95385-Ag-1	Feline IL12B protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T95385-Ag-1	Canine IL12B protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T95385-Ag-1	Bovine IL12B protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T95385-Ag-1	Equine IL12B protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T95385-Ag, GM-Tg-rg-T95385-Ag, GM-Tg-mg-T95385-Ag, GM-Tg-cynog-T95385-Ag, GM-Tg-felg-T95385-Ag, GM-Tg-cang-T95385-Ag, GM-Tg-bovg-T95385-Ag, GM-Tg-equg-T95385-Ag-1
Products Name	IL12B protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	IL12B
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL12B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.