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Description of Small molecules (Chemicals, Antibiotics,Mycotoxins,Hormones,Drugs of Abuse, etc.)

Ivermectin is an orally bioavailable macrocyclic lactone derived from Streptomyces avermitilis, with antiparasitic and potential anti-viral activities. Upon administration, ivermectin exerts its anthelmintic effect through binding and activating glutamate-gated chloride channels (GluCls) expressed on nematode neurons and pharyngeal muscle cells. This causes increased permeability of chloride ions, causing a state of hyperpolarization and results in the paralysis and death of the parasite. Ivermectin may exerts its antiviral effect, including its potential activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), by binding to the importin (IMP) alpha/beta1 heterodimer, which is responsible for the nuclear import of viral proteins such as the integrase (IN) protein. This inhibits nuclear import of host and viral proteins and may inhibit viral replication.

Ivermectin is an antiinfective agent with activity against several parasitic nematodes and scabies and is the treatment of choice for onchocerciasis (river blindness). It is typically given as one or two oral doses. Ivermectin therapy has been associated with minor, self-limiting serum aminotransferase elevations and very rare instances of clinically apparent liver injury.

LSM-5397 is a milbemycin.

Order informatioin


Delivery impact due to the Coronavirus Outbreak

With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No. Description Price(In USD) Qty (Quantity) Sum(In USD)
GMP-SMT-27-1 1. BSA-Ivermectin (IVM); Size:1mg
2. Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:1mg
1365.5
GMP-SMT-27-1 1. BSA-Ivermectin (IVM); Size:10mg
2. Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:10mg
8232.5
GMP-SMT-27-1 1. BSA-Ivermectin (IVM); Size:100mg
2. Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:100mg
41160.5
GMP-SMT-27-2 1. OVA-Ivermectin (IVM); Size:1mg
2. Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:1mg
1365.5
GMP-SMT-27-2 1. OVA-Ivermectin (IVM); Size:10mg
2. Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:10mg
8232.5
GMP-SMT-27-2 1. OVA-Ivermectin (IVM); Size:100mg
2. Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:100mg
41160.5
GMP-SMT-27-Ab-1 Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:1mg 1043.5
GMP-SMT-27-Ab-1 Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:10mg 6272.5
GMP-SMT-27-Ab-1 Anti-Ivermectin (IVM) mouse monoclonal antibody; Size:100mg 31360.5
GMP-SMT-27-Ag-1 BSA-Ivermectin (IVM); Size:1mg 756.5
GMP-SMT-27-Ag-1 BSA-Ivermectin (IVM); Size:10mg 4536.5
GMP-SMT-27-Ag-1 BSA-Ivermectin (IVM); Size:100mg 22960.5
GMP-SMT-27-Ag-2 OVA-Ivermectin (IVM); Size:1mg 756.5
GMP-SMT-27-Ag-2 OVA-Ivermectin (IVM); Size:10mg 4536.5
GMP-SMT-27-Ag-2 OVA-Ivermectin (IVM); Size:100mg 22960.5
GMP-SMT-27 ≥100mg Inquiry
Shipping Cost: 760.00
Total:



Description


BSA-Ivermectin (IVM)

Cat No. GMP-SMT-27-Ag-1
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [BSA-Ivermectin (IVM)]with anti-Hapten antibody. The hapten hapten-carrier conjugates [BSA-Ivermectin (IVM)] had been validated with our anti-Hapten antibody[Anti-Ivermectin (IVM) mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


OVA-Ivermectin (IVM)

Cat No. GMP-SMT-27-Ag-2
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [ OVA-Ivermectin (IVM)] with anti-Hapten antibody. The hapten hapten-carrier conjugates[ OVA-Ivermectin (IVM)] had been validated with our anti-Hapten antibody[Anti-Ivermectin (IVM) mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Anti-Ivermectin (IVM) mouse monoclonal antibody

Cat No. GMP-SMT-27-Ab-1
Host of Antibody Mouse IgG
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb) 3-4
Products description The anti-Hapten antibody against hapten [Ivermectin (IVM)] had beenvalidated with our hapten hapten-carrier conjugates [BSA-Ivermectin (IVM)] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.