Feline Panleukopenia Virus VP2 antibody and antigen (recombinant protein)

Diagnostic anti-Feline Panleukopenia Virus VP2 antibodies pairs and antigen for animal health (animal Cat/Feline infectious disease Feline infectious enteritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P014-Tg001-Ag01 Recombinant Feline Panleukopenia Virus VP2 protein $3090.00
GMP-VT-P014-Tg001-Ab01 Anti-Feline Panleukopenia Virus VP2 mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P014-Tg001-Ab02 Anti-Feline Panleukopenia Virus VP2 mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P014-Tg001-Ab03 Anti-Feline Panleukopenia Virus VP2 human monoclonal antibody (mAb) $3090.00
GMP-VT-P014-Tg001-Ab04 Anti-Feline Panleukopenia Virus VP2 human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P014-Tg001-Ag01
Product Name Recombinant Feline Panleukopenia Virus VP2 protein
Pathogen Feline Panleukopenia Virus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Feline Panleukopenia Virus VP2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Feline Panleukopenia Virus level test of animal Cat/Feline infectious disease with Feline infectious enteritis.
Tag His
Product description Recombinant Feline Panleukopenia Virus VP2 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P014-Tg001-Ab01,GMP-VT-P014-Tg001-Ab02
Pathogen Feline Panleukopenia Virus
Product Name Anti-Feline Panleukopenia Virus VP2 mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Feline Panleukopenia Virus VP2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Panleukopenia Virus antibodies in Feline Panleukopenia Virus level test of animal Cat/Feline infectious disease with Feline infectious enteritis.
Product description Anti-Feline Panleukopenia Virus VP2 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Panleukopenia Virus antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P014-Tg001-Ab03,GMP-VT-P014-Tg001-Ab04
Pathogen Feline Panleukopenia Virus
Product Name Anti-Feline Panleukopenia Virus VP2 human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Feline Panleukopenia Virus VP2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Panleukopenia Virus antibodies in Feline Panleukopenia Virus level test of animal Cat/Feline infectious disease with Feline infectious enteritis.
Product description Anti-Feline Panleukopenia Virus VP2 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen Information


    Introduction:

    Feline Panleukopenia Virus (FPV), a crucial agent in veterinary virology, has piqued significant interest due to its pathological impact on domestic and wild feline populations. This report delves deeply into the nomenclature, taxonomy, structural components, host range, disease manifestation, and diagnostic modalities related to FPV.

    Nomenclature and Synonyms:

    Primary Designation: Feline Panleukopenia Virus is the standardized name recognized by various scientific bodies. The term "panleukopenia" is derived from the Greek roots, signifying the marked decrease in the number of white blood cells typically seen in affected animals.

    Alternate References:

    Feline Parvovirus: A name that underscores its affiliation with the Parvoviridae family.

    Feline Infectious Enteritis: Highlights the gastrointestinal afflictions caused by the virus.

    Cat Distemper: An older, colloquial term that draws parallels with canine distemper, albeit the diseases and causative agents are distinct.

    Taxonomic Breakdown:

    Class: Viruses – a vast group of infectious agents, markedly smaller than bacteria and capable of replication only inside living cells.

    Family: Parvoviridae – a family of small DNA viruses that infect vertebrates.

    Genus: Parvovirus – a genus under Parvoviridae, which consists of several species infecting different animals.

    Viral Genome and Structural Overview:

    FPV's architecture offers insights into its modus operandi within host organisms. Characterized by a non-enveloped icosahedral symmetry and a single-stranded DNA genome, the virus showcases specific attributes:

    Predominant Genes: NS1, the nonstructural protein gene, plays a central role in viral replication. Simultaneously, genes encoding capsid proteins, VP1/VP2, facilitate the virus's structural integrity and interaction with host cells.

    Principal Proteins: VP1 and VP2, the capsid proteins, are crucial for the viral assembly process and its subsequent infectivity.

    Host Specificity and Disease Profiling:

    FPV's host range primarily encompasses:

    Primary Host: Felis catus, or the domestic cat, represents the main victim of FPV infections, exhibiting pronounced clinical manifestations.

    Secondary Hosts: While FPV predominantly affects domesticated cats, the virus doesn't discriminate entirely, occasionally causing infections in wild felids, raccoons, minks, and even ferrets.

    Disease Implications: FPV induces a spectrum of clinical manifestations:

    Feline Panleukopenia: A multifaceted ailment, panleukopenia is synonymous with feline distemper or feline infectious enteritis. Afflicted animals present with gastrointestinal, immunological, and occasionally, neurological disturbances. Typical symptoms might encompass vomiting, diarrhea, fever, lethargy, and sudden death.

    Advanced Diagnostic Modalities and Molecular Probes:

    Accurate diagnosis remains paramount to manage and potentially counteract FPV outbreaks. Modern techniques include:

    Hematological Analysis: A significant drop in white blood cell counts serves as a diagnostic red flag.

    ELISA: Leveraging antibodies' specificity, ELISA detects FPV antigens predominantly in fecal specimens.

    PCR: This gold standard technique amplifies trace amounts of FPV DNA, ensuring precise pathogen identification.

    Immunofluorescence Assay: Through fluorescent markers, this assay discerns viral antigens in tissue or fecal samples.

    Targeted Molecular Probes: Diagnostic precision hinges on targeting specific viral constituents. In the case of FPV, diagnostic procedures focus on the NS1 gene and the capsid proteins, VP1 and VP2, due to their vital roles in the virus's life cycle.

    Conclusion:

    FPV, with its profound impact on feline populations, necessitates an in-depth understanding for effective clinical management. By unraveling its genetic makeup, structural nuances, and the spectrum of its pathological impact, the scientific community can pave the way for more effective preventive and therapeutic measures. As always, staying updated with the latest scientific publications ensures a comprehensive grasp of this ever-evolving subject.



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