Swine enteric coronavirus nucleo (N) protein antibody and antigen (recombinant protein)

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Diagnostic anti-Swine enteric coronavirus nucleo (N) protein antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease Swine enteric coronavirus disease (SECD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P098-Tg002-Ag01	Recombinant Swine enteric coronavirus nucleo (N) protein protein	$3090.00
GMP-VT-P098-Tg002-Ab01	Anti-Swine enteric coronavirus nucleo (N) protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P098-Tg002-Ab02	Anti-Swine enteric coronavirus nucleo (N) protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P098-Tg002-Ab03	Anti-Swine enteric coronavirus nucleo (N) protein human monoclonal antibody (mAb)	$3090.00
GMP-VT-P098-Tg002-Ab04	Anti-Swine enteric coronavirus nucleo (N) protein human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P098-Tg002-Ag01
Product Name	Recombinant Swine enteric coronavirus nucleo (N) protein protein
Pathogen	Swine enteric coronavirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Swine enteric coronavirus nucleo (N) protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Swine enteric coronavirus level test of animal Swine/Porcine/Pig infectious disease with Swine enteric coronavirus disease (SECD).
Tag	His
Product description	Recombinant Swine enteric coronavirus nucleo (N) protein proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P098-Tg002-Ab01,GMP-VT-P098-Tg002-Ab02
Pathogen	Swine enteric coronavirus
Product Name	Anti-Swine enteric coronavirus nucleo (N) protein mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Swine enteric coronavirus nucleo (N) protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Swine enteric coronavirus antibodies in Swine enteric coronavirus level test of animal Swine/Porcine/Pig infectious disease with Swine enteric coronavirus disease (SECD).
Product description	Anti-Swine enteric coronavirus nucleo (N) protein mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Swine enteric coronavirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P098-Tg002-Ab03,GMP-VT-P098-Tg002-Ab04
Pathogen	Swine enteric coronavirus
Product Name	Anti-Swine enteric coronavirus nucleo (N) protein human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Swine enteric coronavirus nucleo (N) protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Swine enteric coronavirus antibodies in Swine enteric coronavirus level test of animal Swine/Porcine/Pig infectious disease with Swine enteric coronavirus disease (SECD).
Product description	Anti-Swine enteric coronavirus nucleo (N) protein mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Swine enteric coronavirus, or Porcine Epidemic Diarrhea Virus (PEDV), is a highly infectious virus that belongs to the Alphacoronavirus genus and is widely recognized as a significant threat to the pig farming industry worldwide. PEDV was first identified in the United Kingdom in 1971 and has since spread to many other regions globally.

Swine enteric coronavirus is a small, enveloped virion with a characteristic crown-like appearance under electron microscopy. The viral genome of swine enteric coronavirus contains a single-stranded RNA molecule of approximately 28 kilobases, which encodes several structural and non-structural proteins required for the virus's replication and pathogenesis.

The spike protein, encoded by the spike gene, plays a vital role in swine enteric coronavirus's pathogenesis and immunity. The spike protein mediates virus-cell attachment and entry through its interaction with the host cell receptor, angiotensin-converting enzyme 2 (ACE2), and facilitates membrane fusion between the virus and host cell. The spike protein's receptor-binding domain (RBD) is located at the C-terminal end of the protein and interacts specifically with ACE2. Additionally, the spike protein elicits neutralizing antibodies that can provide protection against future exposure to the virus.

Swine enteric coronavirus mainly infects domestic pigs of all ages, although the severity of disease differs between age categories. Clinical signs of PEDV infection include acute diarrhea, vomiting, anorexia, dehydration, and lethargy. Additionally, severe cases may result in high mortality rates, especially in neonatal piglets.

To diagnose swine enteric coronavirus, several diagnostic techniques are used, including nucleic acid-based detection methods such as PCR and ELISA. These techniques target specific viral genes or proteins, such as the nucleocapsid gene or the spike protein, to detect the presence of the virus. Traditional diagnostic approaches such as virus isolation and electron microscopy are also available. Accurate and timely diagnosis is critical in controlling the spread of the virus and protecting pig health.

The transmission mechanisms of swine enteric coronavirus are still under investigation, but the virus likely spreads via the fecal-oral route or aerosolized particles. Additionally, indirect contact with fomites contaminated with the virus may also contribute to the viral spread within and between farms.

Several vaccines against swine enteric coronavirus have been developed, and their efficacy is currently being evaluated. Moreover, various control measures have been implemented to prevent and control PEDV outbreaks, including the use of disinfectants, biosecurity protocols, and quarantine procedures.

In conclusion, Swine enteric coronavirus is a highly contagious virus that poses a severe threat to pig farming worldwide. Its pathogenesis involves several viral genes and proteins, including the spike protein, which interacts with the host cell receptor ACE2. Effective diagnosis and control measures are necessary to limit its spread and prevent costly morbidity and mortality in pig populations.

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