Classical Swine Fever Virus Glycoprotein E2 antibody and antigen (recombinant protein)

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Diagnostic anti-Classical Swine Fever Virus Glycoprotein E2 antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease Classical swine fever) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P106-Tg001-Ag01	Recombinant Classical Swine Fever Virus Glycoprotein E2 protein	$3090.00
GMP-VT-P106-Tg001-Ab01	Anti-Classical Swine Fever Virus Glycoprotein E2 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P106-Tg001-Ab02	Anti-Classical Swine Fever Virus Glycoprotein E2 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P106-Tg001-Ab03	Anti-Classical Swine Fever Virus Glycoprotein E2 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P106-Tg001-Ab04	Anti-Classical Swine Fever Virus Glycoprotein E2 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P106-Tg001-Ag01
Product Name	Recombinant Classical Swine Fever Virus Glycoprotein E2 protein
Pathogen	Classical Swine Fever Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Classical Swine Fever Virus Glycoprotein E2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Classical Swine Fever Virus level test of animal Swine/Porcine/Pig infectious disease with Classical swine fever.
Tag	His
Product description	Recombinant Classical Swine Fever Virus Glycoprotein E2 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P106-Tg001-Ab01,GMP-VT-P106-Tg001-Ab02
Pathogen	Classical Swine Fever Virus
Product Name	Anti-Classical Swine Fever Virus Glycoprotein E2 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Classical Swine Fever Virus Glycoprotein E2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Classical Swine Fever Virus antibodies in Classical Swine Fever Virus level test of animal Swine/Porcine/Pig infectious disease with Classical swine fever.
Product description	Anti-Classical Swine Fever Virus Glycoprotein E2 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Classical Swine Fever Virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P106-Tg001-Ab03,GMP-VT-P106-Tg001-Ab04
Pathogen	Classical Swine Fever Virus
Product Name	Anti-Classical Swine Fever Virus Glycoprotein E2 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Classical Swine Fever Virus Glycoprotein E2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Classical Swine Fever Virus antibodies in Classical Swine Fever Virus level test of animal Swine/Porcine/Pig infectious disease with Classical swine fever.
Product description	Anti-Classical Swine Fever Virus Glycoprotein E2 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Classical Swine Fever Virus (CSFV) is a highly contagious viral pathogen that causes Classical Swine Fever, Hog Cholera, or Pig Plague in domestic pigs and wild boars. The disease is characterized by various clinical symptoms, including fever, anorexia, lethargy, diarrhea, vomiting, respiratory distress, and even death in some cases. The disease has a significant economic impact on the swine industry due to the high morbidity and mortality rates, trade restrictions imposed by affected countries, and the cost of control measures and vaccination programs.

CSFV belongs to the genus Pestivirus of the family Flaviviridae, which includes other important animal pathogens, such as Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV). Pestiviruses are positive-sense single-stranded RNA viruses that replicate in the cytoplasm of host cells. The CSFV genome is about 12.3 kilobases long and encodes for a single polyprotein that is processed into individual structural and non-structural proteins.

The structural proteins of CSFV include membrane glycoproteins E1 and E2, which are involved in virus entry into target cells and immune evasion. These glycoproteins contain neutralizing epitopes that are targets for vaccine development and serological diagnostic tests. The nucleocapsid protein N encapsidates the viral genome and interacts with viral RNA during replication. The envelope glycoproteins and nucleocapsid protein are targets for serological diagnostic tests, such as ELISA and virus neutralization tests.

The non-structural proteins of CSFV are involved in viral replication, immune evasion, and modulation of host cell functions. These proteins include proteases, helicase, and RNA-dependent RNA polymerase. Proteases cleave the polyprotein into individual proteins, while helicase unwinds the viral RNA during replication. RNA-dependent RNA polymerase synthesizes new viral RNA copies using the input viral RNA as a template. The non-structural proteins are potential targets for antiviral drugs and vaccines.

CSFV spreads rapidly between pigs through various routes, such as direct contact with infected animals, ingestion of contaminated feces or feed, and aerosol transmission. The virus also remains infectious in pork products, which can serve as a source of infection for susceptible animals. Wild boars can act as a reservoir for the virus and pose a risk of introducing the disease into domestic pig populations. Therefore, effective control measures and surveillance programs are essential to prevent the spread of CSFV.

Diagnostic methods for CSFV include both serological and molecular tests. Serological tests detect antibodies against the virus in serum or plasma samples collected from infected animals. ELISA and virus neutralization tests are commonly used serological diagnostic tests for CSFV. Molecular tests detect viral RNA in blood or tissue samples using nucleic acid amplification techniques, such as RT-PCR. The 5' untranslated region of the viral genome and the envelope glycoprotein E2 are commonly targeted for molecular diagnostic tests.

Control measures for CSFV include vaccination, strict biosecurity protocols, and culling of infected animals. Vaccines based on live attenuated viruses or inactivated viruses are available in some countries and have been shown to provide effective protection against CSFV. However, vaccine efficacy can be compromised by genetic variation among different CSFV strains and the emergence of new viral variants. Therefore, continued surveillance and monitoring of CSFV circulating in pig populations are necessary to maintain effective control measures and minimize the impact of this important swine pathogen.

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