Transmissible gastroenteritis coronavirus Glycoprotein S antibody and antigen (recombinant protein)

Diagnostic anti-Transmissible gastroenteritis coronavirus Glycoprotein S antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease viral enteritis and diarrhea) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Swine/Porcine/Pig disease testing products collection >>


Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P109-Tg001-Ag01 Recombinant Transmissible gastroenteritis coronavirus Glycoprotein S protein $3090.00
GMP-VT-P109-Tg001-Ab01 Anti-Transmissible gastroenteritis coronavirus Glycoprotein S mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P109-Tg001-Ab02 Anti-Transmissible gastroenteritis coronavirus Glycoprotein S mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P109-Tg001-Ab03 Anti-Transmissible gastroenteritis coronavirus Glycoprotein S human monoclonal antibody (mAb) $3090.00
GMP-VT-P109-Tg001-Ab04 Anti-Transmissible gastroenteritis coronavirus Glycoprotein S human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P109-Tg001-Ag01
Product Name Recombinant Transmissible gastroenteritis coronavirus Glycoprotein S protein
Pathogen Transmissible gastroenteritis coronavirus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Transmissible gastroenteritis coronavirus Glycoprotein S antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Transmissible gastroenteritis coronavirus level test of animal Swine/Porcine/Pig infectious disease with viral enteritis and diarrhea.
Tag His
Product description Recombinant Transmissible gastroenteritis coronavirus Glycoprotein S proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P109-Tg001-Ab01,GMP-VT-P109-Tg001-Ab02
Pathogen Transmissible gastroenteritis coronavirus
Product Name Anti-Transmissible gastroenteritis coronavirus Glycoprotein S mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Transmissible gastroenteritis coronavirus Glycoprotein S antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Transmissible gastroenteritis coronavirus antibodies in Transmissible gastroenteritis coronavirus level test of animal Swine/Porcine/Pig infectious disease with viral enteritis and diarrhea.
Product description Anti-Transmissible gastroenteritis coronavirus Glycoprotein S mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Transmissible gastroenteritis coronavirus antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P109-Tg001-Ab03,GMP-VT-P109-Tg001-Ab04
Pathogen Transmissible gastroenteritis coronavirus
Product Name Anti-Transmissible gastroenteritis coronavirus Glycoprotein S human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Transmissible gastroenteritis coronavirus Glycoprotein S antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Transmissible gastroenteritis coronavirus antibodies in Transmissible gastroenteritis coronavirus level test of animal Swine/Porcine/Pig infectious disease with viral enteritis and diarrhea.
Product description Anti-Transmissible gastroenteritis coronavirus Glycoprotein S mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Pathogen Information


    Taxonomy and Classification:

    Actinobacillus pleuropneumoniae (APP) is a Gram-negative bacterium known for causing porcine pleuropneumonia, a highly contagious respiratory disease in swine. Understanding the taxonomy and classification of APP is fundamental to comprehending its characteristics and behavior.

    APP belongs to the phylum Proteobacteria, placing it within the same bacterial group as other notable pathogens like Escherichia coli and Salmonella. More specifically, it falls under the class Gammaproteobacteria, order Pasteurellales, and family Pasteurellaceae. This classification places it in the same family as other significant veterinary pathogens, such as Mannheimia haemolytica and Pasteurella multocida.

    Within the genus Actinobacillus, APP stands out as a prominent pathogen in swine. It's essential to recognize that there are multiple serotypes (1-11) of APP, and these serotypes exhibit variations in virulence and geographic distribution. Understanding the serotype of the infecting strain is crucial for disease management and vaccine development.

    Pathogen Structure and Virulence Factors:

    To comprehend how APP affects swine and causes porcine pleuropneumonia, it's vital to examine its structure and the virulence factors that enable it to infect and damage its host.

    APP is a coccobacillus, a type of bacterium that is intermediate in shape between a coccus (spherical) and a bacillus (rod-shaped). This shape is common among many pathogens in the Pasteurellaceae family and plays a role in their ability to invade and persist in host tissues.

    A key to APP's pathogenicity lies in its production of cytotoxins known as Apx toxins. There are three primary Apx toxins: ApxI, ApxII, and ApxIII. These toxins are crucial for causing lung lesions and cellular damage in the host. ApxI and ApxII toxins contribute to the characteristic pathology of porcine pleuropneumonia by targeting and damaging pulmonary epithelial cells. ApxIII toxin, while less studied, also plays a role in the disease's development.

    In addition to Apx toxins, lipopolysaccharides (LPS) on the bacterial cell surface play a significant role in APP's pathogenicity. LPS is a component of the outer membrane of Gram-negative bacteria and acts as a potent trigger for inflammatory responses in the host. This leads to a cascade of immune reactions, exacerbating the severity of the disease.

    Impact on Hosts and Associated Diseases:

    Porcine pleuropneumonia, caused by APP, is a significant concern in the swine industry due to its impact on host animals. The clinical manifestations of the disease can vary in severity, ranging from acute to chronic. Infected pigs often exhibit symptoms such as coughing, labored breathing, fever, and pleurisy, which is inflammation of the membranes surrounding the lungs.

    In severe cases, porcine pleuropneumonia can lead to high mortality rates and substantial economic losses. Diseased animals may experience reduced weight gain and impaired feed conversion, leading to decreased productivity in swine farms. In addition to the acute form, there is also a chronic form of the disease, which can result in long-term health issues and reduced performance in affected pigs.

    Diagnostic Methods:

    Accurate and timely diagnosis of porcine pleuropneumonia is essential for disease management. Various diagnostic methods are employed by veterinarians and researchers to identify and confirm the presence of APP:

    Polymerase Chain Reaction (PCR): PCR-based tests are used to amplify specific genes of APP, such as the ApxIV gene, allowing for rapid and precise detection in clinical samples.

    Enzyme-Linked Immunosorbent Assay (ELISA): This serological test is designed to detect antibodies or antigens against APP in blood samples, aiding in diagnosis.

    Nucleic Acid Hybridization: Utilizing nucleic acid probes, this method detects APP DNA in clinical samples, providing another approach to confirm the infection.

    Culturing and Isolation: Although less common due to its time-consuming nature, culturing samples on specific growth media can help isolate APP for further analysis and strain characterization.

    Prevention and Control:

    Preventing APP infection is a multifaceted challenge but is crucial for maintaining swine health and productivity. Key strategies for prevention and control include:

    Biosecurity Measures: Implementing strict biosecurity measures to prevent the introduction and spread of the bacterium within swine herds.

    Vaccination: Several vaccines targeting prevalent serotypes of APP have been developed to provide immunity in susceptible pig populations. These vaccines aim to reduce the severity and impact of porcine pleuropneumonia.

    Hygiene Protocols: Maintaining good hygiene practices in swine farms and controlling factors that can stress the animals, such as overcrowding, can help reduce the likelihood of APP infections.

    Quarantine: Isolating and monitoring newly introduced animals can prevent the introduction of the pathogen to existing swine populations.

    Research and Future Prospects:

    Ongoing research in the field of porcine pleuropneumonia and APP continues to advance our understanding of this pathogen and the disease it causes. Areas of active research include:

    Genetic Diversity: Scientists are studying the genetic diversity of APP strains to better understand how different serotypes vary in terms of virulence and geographical distribution.

    Virulence Factors: Investigating the mechanisms by which APP's virulence factors, such as Apx toxins, interact with the host and cause disease.

    Vaccine Development: Developing new and improved vaccines that target multiple serotypes and provide broader protection against porcine pleuropneumonia.

    Diagnostic Tools: Refining diagnostic tools to improve their accuracy and efficiency, which is critical for early detection and management of the disease.



    About GDU


    GDU

    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.