Avian Metapneumovirus Subtype A&B NP antibody and antigen (recombinant protein)
Diagnostic anti-Avian Metapneumovirus Subtype A&B NP antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Avian metapneumovirus infection) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-VT-P196-Tg001-Ag01 | Recombinant Avian Metapneumovirus Subtype A&B NP protein | $3090.00 |
GMP-VT-P196-Tg001-Ab01 | Anti-Avian Metapneumovirus Subtype A&B NP mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P196-Tg001-Ab02 | Anti-Avian Metapneumovirus Subtype A&B NP mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P196-Tg001-Ab03 | Anti-Avian Metapneumovirus Subtype A&B NP human monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P196-Tg001-Ab04 | Anti-Avian Metapneumovirus Subtype A&B NP human monoclonal antibody (mAb) | $3090.00 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. | GMP-VT-P196-Tg001-Ag01 |
Product Name | Recombinant Avian Metapneumovirus Subtype A&B NP protein |
Pathogen | Avian Metapneumovirus Subtype A&B |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Anti-Avian Metapneumovirus Subtype A&B NP antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Metapneumovirus Subtype A&B level test of animal Avian/Bird/Poultry infectious disease with Avian metapneumovirus infection. |
Tag | His | Product description | Recombinant Avian Metapneumovirus Subtype A&B NP proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P196-Tg001-Ab01,GMP-VT-P196-Tg001-Ab02 |
Pathogen | Avian Metapneumovirus Subtype A&B |
Product Name | Anti-Avian Metapneumovirus Subtype A&B NP mouse monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Recombinant Avian Metapneumovirus Subtype A&B NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Metapneumovirus Subtype A&B antibodies in Avian Metapneumovirus Subtype A&B level test of animal Avian/Bird/Poultry infectious disease with Avian metapneumovirus infection. |
Product description | Anti-Avian Metapneumovirus Subtype A&B NP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Metapneumovirus Subtype A&B antibodies. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P196-Tg001-Ab03,GMP-VT-P196-Tg001-Ab04 |
Pathogen | Avian Metapneumovirus Subtype A&B |
Product Name | Anti-Avian Metapneumovirus Subtype A&B NP human monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Human lgG1 |
Bioactivity validation | Recombinant Avian Metapneumovirus Subtype A&B NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Metapneumovirus Subtype A&B antibodies in Avian Metapneumovirus Subtype A&B level test of animal Avian/Bird/Poultry infectious disease with Avian metapneumovirus infection. |
Product description | Anti-Avian Metapneumovirus Subtype A&B NP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
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Pathogen Information
Avian Metapneumovirus Subtype A and B (AMPV-A & AMPV-B): A Comprehensive Examination
Avian Metapneumovirus, comprising Subtypes A and B (AMPV-A & AMPV-B), stands as a significant pathogenic entity within the Pneumoviridae family. This diverse family of viruses, characterized by a single-stranded, negative-sense RNA genome, encompasses several human and avian pathogens. Among them, AMPV-A and AMPV-B have emerged as notorious culprits in avian respiratory diseases, causing substantial economic losses in the poultry industry worldwide.
Structural Insights:
At the heart of AMPV-A and AMPV-B's pathogenicity lie their intricate genetic structures. The viral genome encodes essential proteins vital for the viral life cycle. The Fusion (F) protein, a transmembrane glycoprotein, plays a pivotal role in facilitating membrane fusion between the viral envelope and host cell membranes, enabling viral entry into the host cell. Another critical glycoprotein, the Attachment (G) protein, is responsible for binding the virus to host cell receptors, initiating the infection process. The Nucleoprotein (N) encapsulates the viral RNA genome, safeguarding it during various stages of the replication cycle. Additionally, the Phosphoprotein (P) plays a regulatory role in RNA synthesis, ensuring precise replication and transcription processes. Lastly, the Large Polymerase (L) protein serves as the RNA-dependent RNA polymerase, orchestrating the replication and transcription of the viral genome.
Host Range and Disease Impact:
AMPV-A and AMPV-B exhibit a broad host range, predominantly affecting avian species such as chickens and turkeys. In infected poultry, AMPV-A manifests as Avian Rhinotracheitis (ART), characterized by respiratory distress, nasal discharge, and a drop in egg production. On the other front, AMPV-B leads to Swollen Head Syndrome (SHS) and respiratory complications, severely compromising the overall health and productivity of affected birds. These diseases not only cause direct morbidity and mortality but also significantly impair flock growth rates, feed conversion, and egg quality, posing substantial challenges to the poultry industry.
Diagnostic Approaches:
Rapid and accurate diagnosis of AMPV-A and AMPV-B infections is imperative for implementing timely control measures. Molecular diagnostic techniques have proven invaluable in this regard. Polymerase Chain Reaction (PCR), a widely employed method, amplifies specific regions of the viral genome, such as the F or G genes, enabling sensitive and specific detection of the viral genetic material. Reverse Transcription PCR (RT-PCR) further refines this approach, specifically targeting RNA molecules, thus allowing for the identification and quantification of viral RNA. Real-Time PCR (qPCR), an advancement in PCR technology, offers enhanced sensitivity and enables quantitative assessment of viral RNA concentration, aiding in disease monitoring and surveillance efforts.
Complementing these molecular methods, serological techniques such as Enzyme-Linked Immunosorbent Assay (ELISA) play a pivotal role in detecting antibodies specific to AMPV-A and AMPV-B. By identifying the presence of these antibodies in avian hosts, ELISA tests provide valuable insights into the prevalence of the virus within poultry populations, guiding vaccination strategies and biosecurity measures.
In conclusion, the comprehensive understanding of AMPV-A and AMPV-B, from their genetic structure to their impact on avian health, is essential for the effective management of avian respiratory diseases. Accurate diagnostic methodologies empower veterinarians and researchers to swiftly identify infections, allowing for timely interventions to curb the spread of these pathogens. Continued research and vigilance are vital to stay ahead of the evolutionary adaptations of AMPV-A and AMPV-B, ensuring the sustained health and productivity of avian populations globally.
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