Koi Herpes Virus KHV ORF 149 antibody and antigen (recombinant protein)

Diagnostic anti-Koi Herpes Virus KHV ORF 149 antibodies pairs and antigen for animal health (animal Cyprinus carpio and its ornamental varieties infectious disease Koi herpesvirus disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P227-Tg001-Ag01 Recombinant Koi Herpes Virus KHV ORF 149 protein $3090.00
GMP-VT-P227-Tg001-Ab01 Anti-Koi Herpes Virus KHV ORF 149 mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P227-Tg001-Ab02 Anti-Koi Herpes Virus KHV ORF 149 mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P227-Tg001-Ab03 Anti-Koi Herpes Virus KHV ORF 149 human monoclonal antibody (mAb) $3090.00
GMP-VT-P227-Tg001-Ab04 Anti-Koi Herpes Virus KHV ORF 149 human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P227-Tg001-Ag01
Product Name Recombinant Koi Herpes Virus KHV ORF 149 protein
Pathogen Koi Herpes Virus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Koi Herpes Virus KHV ORF 149 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Koi Herpes Virus level test of animal Cyprinus carpio and its ornamental varieties infectious disease with Koi herpesvirus disease.
Tag His
Product description Recombinant Koi Herpes Virus KHV ORF 149 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P227-Tg001-Ab01,GMP-VT-P227-Tg001-Ab02
Pathogen Koi Herpes Virus
Product Name Anti-Koi Herpes Virus KHV ORF 149 mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Koi Herpes Virus KHV ORF 149 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Koi Herpes Virus antibodies in Koi Herpes Virus level test of animal Cyprinus carpio and its ornamental varieties infectious disease with Koi herpesvirus disease.
Product description Anti-Koi Herpes Virus KHV ORF 149 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Koi Herpes Virus antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P227-Tg001-Ab03,GMP-VT-P227-Tg001-Ab04
Pathogen Koi Herpes Virus
Product Name Anti-Koi Herpes Virus KHV ORF 149 human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Koi Herpes Virus KHV ORF 149 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Koi Herpes Virus antibodies in Koi Herpes Virus level test of animal Cyprinus carpio and its ornamental varieties infectious disease with Koi herpesvirus disease.
Product description Anti-Koi Herpes Virus KHV ORF 149 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen Information


    KHV is a highly infectious virus that has become a significant concern for koi and common carp farmers worldwide. This virus primarily infects members of the family Cyprinidae, causing a disease known as Koi Herpesvirus Disease (KHVD).

    KHVD was first reported in Israel in 1998, and since then, outbreaks have occurred in several countries, including Japan, the United States, Canada, and Europe. KHV has been classified as a notifiable disease by the World Organisation for Animal Health (OIE), emphasizing the importance of controlling its spread to maintaining fish welfare and industry sustainability.

    KHV has a complex and distinct viral genome, with structural and nonstructural genes encoding various proteins that are involved in its replication and infection of host cells. The genome of KHV has been sequenced, and several genes have been identified, including those encoding for the capsid protein, envelope protein, tegument protein, DNA polymerase, and thymidine kinase.

    The capsid protein is responsible for the formation of the virus's outer layer, which protects the genetic material. The envelope protein contributes to the virus's ability to enter host cells by facilitating fusion with the cell membrane. The tegument protein is involved in regulating gene expression during viral replication. The DNA polymerase enzyme plays a critical role in replicating the KHV genome, while the thymidine kinase gene provides the virus with the ability to phosphorylate nucleosides, enabling viral DNA replication.

    KHV enters the host cell by attaching its envelope protein to the host cell receptor. Once inside the host cell, KHV follows a well-characterized pathway towards replication, leading to the production of new viral particles that can infect other host cells. This process is facilitated by the expression of several virulence factors, including the viral thymidine kinase and DNA polymerase enzymes. These factors aid in the rapid replication of the virus and contribute to its pathogenicity.

    KHVD presents with a range of clinical signs, including lethargy, anorexia, respiratory distress, skin ulcers, and gill necrosis. These signs can appear suddenly or develop over time and are often accompanied by high mortality rates, especially in younger koi and common carp.

    To detect KHV, several diagnostic methods have been developed, which enable prompt detection and management of KHVD. These tests typically target specific regions of the KHV genome, such as the thymidine kinase gene, glycoprotein gene, or envelope protein gene. Examples of commonly used diagnostic tests for KHV include the TaqMan PCR assay and the Loop-mediated isothermal amplification (LAMP) assay.

    In conclusion, KHV is a highly infectious virus that poses a significant threat to the koi and common carp industry. Its complex genome, virulence factors, and distinct clinical signs emphasize the importance of prompt diagnosis and management of KHVD. Ongoing research is being conducted to improve our understanding of KHV's epidemiology, pathogenesis, and treatment options, which will help mitigate the impact of this virus on aquaculture.



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