Diagnostic anti-Cryptosporidium parvum P23 antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease Cryptosporidiosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Genemedi produces core animal health diagnostic ingredients-validated anti-Cryptosporidium parvum P23 antibodies pairs and antigens for rapid test kit of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with Cryptosporidiosis to evaluate the  animal health of Multiple species (Avian/Bird/Poultry, Fish, Pet, Ruminants, Swine/Porcine/Pig).

The paired antibodies are both monoclonal antibodies (mab).

All the antibodies and antigens of  animal disease test are suitable for in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT. The antibody can act as a capture antibody and detection antibody. Antigens are validated as positive control materials.

Cryptosporidiosis, sometimes informally called crypto. It is a parasitic disease caused by Cryptosporidium, a genus of protozoan parasites in the phylum Apicomplexa. It affects the distal small intestine and can affect the respiratory tract in both immunocompetent (i.e., individuals with a normal functioning immune system) and immunocompromised (e.g., persons with HIV/AIDS or autoimmune disorders) individuals, resulting in watery diarrhea with or without an unexplained cough.

Cryptosporidium parvum is a eukaryotic pathogen belonging to the phylum Apicomplexa, family Cryptosporidiidae. Cryptosporidium parvum is an important gastrointestinal parasite of humans and other animals that can be transmitted via contamination of food and water. Typically, the parasite infects the microvillus border of the gastrointestinal epithelium causing persistent diarrhea (Cryptosporidiosis). However, among immunosuppressed individuals, the infection may spread to other parts of the body (e.g. respiratory tract, pancreatic duct, stomach). Cryptosporidium parvum can infect a wide range of vertebrate hosts, including birds, reptiles, humans, livestock, wildlife, and companion animals such as dogs and cats. Cryptosporidium parvum has a complex life cycle involving both asexual and sexual reproduction stages. Its genome contains about 4,800 protein-coding genes. The pathogen possesses various proteins such as surface antigens (gp15, gp40, gp15/40, gp900), microneme proteins (AMA1 and MIC1), and rhoptry proteins (ROP2) as well as enzymes like lactate dehydrogenase (LDH) and glutamate dehydrogenase (GDH).

Several diagnostic methods are available for detecting Cryptosporidium parvum infection. These include microscopy, immunoassays, and nucleic acid-based techniques such as PCR (polymerase chain reaction), RT-PCR (reverse transcription PCR), and LAMP (loop-mediated isothermal amplification). These methods target different genes such as the small subunit ribosomal RNA (SSU rRNA), the Cryptosporidium oocyst wall protein (COWP), and the heat-shock protein 70 (HSP70) gene. Additionally, some immunoassays target specific proteins, such as the Cryptosporidium antigen detection test that detects the Cryptosporidium-specific antigen. Cryptosporidium copro-antigen (CCA) was detected in human and calf stool using enzyme-linked immunosorbent assay (ELBA) and counter immunoelectrophoresis (CIE). In addition, CP23 antigen, a major target of humoral immunity and one of the immunodominant antigens involved in the immune response to Cryptosporidium parvum infection. It is present in both the sporozoite and merozoite stages and is considered a marker of infection because it is recognized by serum antibodies of humans and many animal species.

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