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It's the GeneMedi's summary page for Target/Biomarker Introduction of TNF. The page also collects GeneMedi's different modalities and formats products for TNF in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TNF target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]

Target IDGM-T20178
Target NameTNF
Gene ID7124
Gene Official NameTNF
Gene AliasDIF-alpha, TNFA, TNFSF2, TNLG1F, TNF
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, Diagnostics Biomarker, INN Index, Cytokine Target, Immuno-oncology Target


Pre-made TNF-specific INN-index biosimilar (antibody&conjugates)-Remtolumab, etanercept, Placulumab, Golimumab, lenercept, onercept, pegsunercept, nerelimomab, afelimomab, Licaminlimab, Adalimumab, certolizumab pegol, adalimumab beta, tulinercept, Infliximab, Ozoralizumab, Certolizumab, opinercept

Anti-TNF therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatOrder
GMP-Bios-ab-478Pre-Made Remtolumab biosimilar, Bispecific Dual Variable Domain IG: Anti-IL17A/IL17;TNFA/TNF therapeutic antibodyRemtolumabIL17A/IL17;TNFA/TNFBispecific Dual Variable Domain IGINN mab
GMP-Bios-INN-846Pre-Made Etanercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1FetanerceptTNFFusion ProteinINN mab
GMP-Bios-ab-445Pre-Made Placulumab biosimilar, Single Domain Variable Fragment (VL + Fc), Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyPlaculumabTNFA/TNFSingle Domain Variable Fragment (VL) + FcINN mab
GMP-Bios-ab-249Pre-Made Golimumab biosimilar, Whole mAb, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyGolimumabTNFA/TNFWhole mAbINN mab
GMP-Bios-INN-887Pre-Made Lenercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1FlenerceptTNFFusion ProteinINN mab
GMP-Bios-INN-935Pre-Made Onercept Biosimilar, Recombinant Protein targeting TNF: Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1FonerceptTNFRecombinant ProteinINN mab
GMP-Bios-INN-957pegsunerceptTNFpegylatedINN mab
GMP-Bios-INN-927Pre-Made Nerelimomab Biosimilar, Whole Mab, Anti-Tnf Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodynerelimomabTNFWhole  mAbINN mab
GMP-Bios-INN-721Pre-Made Afelimomab Biosimilar, Fab Fusion, Anti-Tnf Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyafelimomabTNFFab FusionINN mab
GMP-Bios-ab-310Pre-Made Licaminlimab biosimilar, scFv, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyLicaminlimabTNFA/TNFscFvINN mab
GMP-Bios-ab-009Pre-Made Adalimumab biosimilar, Whole mAb, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyAdalimumabTNFA/TNFWhole mAbINN mab
GMP-Bios-INN-776certolizumab pegolTNFpegylatedINN mab
GMP-Bios-INN-718Pre-Made Adalimumab Beta Biosimilar, Whole Mab, Anti-Tnf Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyadalimumab betaTNFWhole  mAbINN mab
GMP-Bios-INN-1036Pre-Made Tulinercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1FtulinerceptTNFFusion ProteinINN mab
GMP-Bios-ab-274Pre-Made Infliximab biosimilar, Whole mAb, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyInfliximabTNFA/TNFWhole mAbINN mab
GMP-Bios-ab-419Pre-Made Ozoralizumab biosimilar, Bispecific Single Domains (VH-VH'-VH), Anti-TNFA/TNF;ALB Antibody: Anti-DIF/TNF-alpha/TNFSF2/TNLG1F;FDAHT/HSA/PRO0883/PRO0903/PRO1341 therapeutic antibodyOzoralizumabTNFA/TNF;ALBBispecific Single Domains (VH-VH'-VH)INN mab
GMP-Bios-ab-100Pre-Made Certolizumab biosimilar, Fab, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibodyCertolizumabTNFA/TNFFabINN mab
GMP-Bios-INN-938Pre-Made Opinercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1FopinerceptTNFFusion ProteinINN mab



Pre-made anti-TNF inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-TNF benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TNF mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-T20178-AbAnti-TNF monoclonal antibodymabBiofunctional antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibodymonoclonal antibody.




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