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Anti-TNFA/ TNF/ DIF-alpha monoclonal antibody
Anti-TNFA/ TNF/ DIF-alpha antibody for FACS & in-vivo assay
Go to TNF/TNF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T20178-Ab-1/ GM-Tg-hg-T20178-Ab-2 | Anti-Human TNF monoclonal antibody | Human |
| GM-Tg-rg-T20178-Ab-1/ GM-Tg-rg-T20178-Ab-2 | Anti-Rat TNF monoclonal antibody | Rat |
| GM-Tg-mg-T20178-Ab-1/ GM-Tg-mg-T20178-Ab-2 | Anti-Mouse TNF monoclonal antibody | Mouse |
| GM-Tg-cynog-T20178-Ab-1/ GM-Tg-cynog-T20178-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T20178-Ab-1/ GM-Tg-felg-T20178-Ab-2 | Anti-Feline TNF monoclonal antibody | Feline |
| GM-Tg-cang-T20178-Ab-1/ GM-Tg-cang-T20178-Ab-2 | Anti-Canine TNF monoclonal antibody | Canine |
| GM-Tg-bovg-T20178-Ab-1/ GM-Tg-bovg-T20178-Ab-2 | Anti-Bovine TNF monoclonal antibody | Bovine |
| GM-Tg-equg-T20178-Ab-1/ GM-Tg-equg-T20178-Ab-2 | Anti-Equine TNF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T20178-Ab-1/ GM-Tg-hg-T20178-Ab-2; GM-Tg-rg-T20178-Ab-1/ GM-Tg-rg-T20178-Ab-2; GM-Tg-mg-T20178-Ab-1/ GM-Tg-mg-T20178-Ab-2; GM-Tg-cynog-T20178-Ab-1/ GM-Tg-cynog-T20178-Ab-2; GM-Tg-felg-T20178-Ab-1/ GM-Tg-felg-T20178-Ab-2; GM-Tg-cang-T20178-Ab-1/ GM-Tg-cang-T20178-Ab-2; GM-Tg-bovg-T20178-Ab-1/ GM-Tg-bovg-T20178-Ab-2; GM-Tg-equg-T20178-Ab-1/ GM-Tg-equg-T20178-Ab-2 |
| Products Name | Anti-TNF monoclonal antibody |
| Format | mab |
| Target Name | TNF |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T20178 |
| Target Name | TNF |
| Gene ID | 7124,21926,24835,715467,403922,493755,280943,100033834 |
| Gene Symbol and Synonyms | cTNF,DIF,RATTNF,TNF,TNF-a,TNF-alpha,TNFA,TNFalpha,Tnfsf1a,TNFSF2,TNLG1F |
| Uniprot Accession | P01375,P16599,P48094,P51742,P19101,Q06599,P29553 |
| Uniprot Entry Name | TNFA_HUMAN,TNFA_MACMU,TNFA_RAT,TNFA_FELCA,TNFA_CANLF,TNFA_BOVIN,TNFA_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Ovary Cancer, toluene diisocyanate asthma, Giant Cell Arteritis, Polymyalgia Rheumatica, Chronic Kidney Disease, Dent disease, Hodgkin's disease, Kidney transplant rejection, pancreatic cancer, Chronic Glomerulonephritis, Asthma |
| Gene Ensembl | ENSG00000232810 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TNF, gene name: TNF, also named as DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF. This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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