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Lepunafusp Alfa Biosimilar Fusion Protein (Transferrin Receptor 1) for Research
Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Lepunafusp alfa is a blood-brain-barrier-penetrating form of recombinant human alpha-L-iduronidase fused to the alpha-L-iduronidase anti-transferrin receptor antibody Fab as pabinafusp alfa. Human alpha-L-iduronidase deficiency causes lysosomal storage disease mucopolysaccharidosis type I which leads to disrupted glycosaminoglycan catabolism.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-888-1mg | 1mg | 3090 |
| GMP-Bios-INN-888-10mg | 10mg | |
| GMP-Bios-INN-888-100mg | 100mg | |
| GMP-Bios-INN-888-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 |
| INN Name | Lepunafusp Alfa |
| Target | TFRC |
| Format | Fusion Protein |
| Derivation | Humanized |
| Species Reactivity | human |
| CH1 Isotype | F(ab')2 - G1 - kappa |
| VD LC | F(ab')2 - G1 - kappa |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | JCR Pharmaceuticals Co., Ltd (Ashiya Japan) |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | 0 |
About target - TFRC
1. Protein Transferrin receptor protein 1
2. Gene TFRC
3. Organism Homo sapiens (Human)
Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738).
Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).
A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738).
When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738).
When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Miscellaneous
Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.
