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52 candidate vaccines in clinical evaluation

COVID-19 Vaccine developer/manufacturer Vaccine platform Type of candidate vaccine Number of doses Timing of doses Route of Adminis-
tration 		Clinical Stage
Phase 1 Phase 1/2 Phase 2 Phase 3
Sinovac Inactivated Inactivated 2 0,14 days IM NCT04383574
NCT04352608
Study Report
NCT04551547 		NCT04456595
669/UN6.KEP/EC/2020
NCT04582344 
NCT04617483
Wuhan Institute of Biological Products/Sinopharm Inactivated Inactivated 2 0,21 days IM ChiCTR2000031809
Interim Report 		ChiCTR2000034780
ChiCTR2000039000
NCT04612972
Beijing Institute of Biological Products/Sinopharm Inactivated Inactivated 2 0,21 days IM ChiCTR2000032459
Study Report 		ChiCTR2000034780
NCT04560881
Bharat Biotech Inactivated Whole-Virion Inactivated 2 0, 28 days IM CTRI/2020/07/026300
CTRI/2020/09/027674
 CTRI/2020/11/028976
NCT04641481
University of Oxford/AstraZeneca Non-Replicating Viral Vector ChAdOx1-S 2 0,28 days IM PACTR202006922165132
2020-001072-15
NCT04568031
Interim Report
 2020-001228-32
Study Report
 ISRCTN89951424
NCT04516746
NCT04540393
CTRI/2020/08/027170
CanSino Biological Inc./Beijing Institute of Biotechnology Non-Replicating Viral Vector Adenovirus Type 5 Vector 1 IM ChiCTR2000030906
NCT04568811
Study Report
 ChiCTR2000031781
NCT04566770
Study Report
 NCT04526990
NCT04540419
Gamaleya Research Institute Non-Replicating Viral Vector Adeno-based (rAd26-S+rAd5-S) 2 0,21 days IM NCT04436471
NCT04437875
Study Report
 NCT04587219
NCT04640233
 NCT04530396
NCT04564716
NCT04642339
Janssen Pharmaceutical Companies Non-Replicating Viral Vector Adenovirus Type 26 vector 1 2 0 0, 56 days IM NCT04436276
NCT04509947
 NCT04535453
 NCT04505722
ISRCTN14722499
Novavax Protein Subunit Full length recombinant SARS CoV-2 glycoprotein nanoparticle vaccine adjuvanted with Matrix M 2 0,21 days IM NCT04368988
Study Report
 NCT04533399
(phase 2b)
 2020-004123-16
NCT04611802
Anhui Zhifei Longcom Biopharmaceutical/Institute of Microbiology, Chinese Academy of Sciences Protein Subunit Adjuvanted recombinant protein (RBD-Dimer) expressed in CHO cells 3 0, 28, 56 days IM NCT04445194
NCT04636333
 NCT04550351
 NCT04466085
 ChiCTR2000040153
Moderna/NIAID RNA LNP-encapsulated mRNA 2 0,28 days IM NCT04283461
Interim Report
Final Report
 NCT04405076
 NCT04470427
BioNTech/Fosun Pharma/Pfizer RNA 3 LNP-mRNAs 2 0,21 days IM NCT04368728
Study Report
 2020-001038-36
ChiCTR2000034825
NCT04537949
NCT04588480
Study Report1
Study Report2
 NCT04368728
Medicago Inc. VLP Plant-derived VLP adjuvanted with AS03. 2 0, 21 days IM NCT04450004
 NCT04636697
Inovio Pharmaceuticals/ International Vaccine Institute DNA DNA plasmid vaccine with electroporation 2 0, 28 days ID NCT04447781
NCT04336410
 NCT04642638
ChiCTR2000040146
Beijing Wantai Biological Pharmacy/ Xiamen University Replicating Viral Vector Intranasal flu-based-RBD 1 IN

West China Hospital, Sichuan University Protein Subunit RBD (baculovirus production expressed in Sf9 cells) 2 or 3 0, 28 days and 0,14, 28 days IM
ChiCTR2000039994
Curevac RNA mRNA 2 0, 28 days IM NCT04449276
 NCT04515147
Institute of Medical Biology, Chinese Academy of Medical Sciences Inactivated Inactivated 2 0, 28 days IM NCT04412538
 NCT04470609
Research Institute for Biological Safety Problems, Rep of Kazakhstan Inactivated Inactivated 2 0, 21 days IM NCT04530357
Shenzhen Kangtai Biological Products Co., Ltd. Inactivated Inactivated 2 IM ChiCTR2000038804
 ChiCTR2000039462
Osaka University/ AnGes/ Takara Bio DNA DNA plasmid vaccine + Adjuvant 2 0, 14 days IM NCT04463472
NCT04527081
Cadila Healthcare Limited DNA DNA plasmid vaccine 3 0, 28, 56 days ID CTRI/2020/07/026352
Genexine Consortium DNA DNA Vaccine (GX-19) 2 0, 28 days IM NCT04445389
Kentucky Bioprocessing, Inc Protein Subunit RBD-based 2 0, 21 days IM NCT04473690
Sanofi Pasteur/GSK Protein Subunit S protein (baculovirus production) 2 0, 21 days IM NCT04537208
Biological E Ltd Protein Subunit Adjuvanted protein subunit (RBD) 2 0, 28 days IM CTRI/2020/11/029032
Israel Institute for Biological Research Replicating Viral Vector VSV-S 1 IM NCT04608305
Arcturus/Duke-NUS RNA mRNA IM NCT04480957
SpyBiotech/Serum Institute of India VLP RBD-HBsAg VLPs 2 0, 28 days IM ACTRN12620000817943
Symvivo DNA bacTRL-Spike 1 Oral NCT04334980
Providence Health & Services DNA electroporated S protein plasmid DNA vaccine with or without the combination of electroporated IL- 12p70 plasmid 2 0, 28 days ID NCT04627675
Codagenix/Serum Institute of India Live Attenuated Virus Codon deoptimized live attenuated vaccines 1 or 2 0 or 0,28 days IN NCT04619628
ImmunityBio, Inc. & NantKwest Inc. Non-Replicating Viral Vector hAd5 S+N 2nd Generation Human Adenovirus Type 5 Vector (hAd5) Spike (S) + Nucleocapsid (N) 2 0, 21 days SC NCT04591717
ReiThera/LEUKOCARE/Univercells Non-Replicating Viral Vector Replication defective Simian Adenovirus (GRAd) encoding S 1 IM NCT04528641
CanSino Biological Inc/Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China Non-Replicating Viral Vector Ad5-nCoV 2 0, 28 days IM/mucosal NCT04552366
Vaxart Non-Replicating Viral Vector Ad5 adjuvanted Oral Vaccine platform 2 0, 28 days Oral NCT04563702
Ludwig-Maximilians - University of Munich Non-Replicating Viral Vector MVA-SARS-2-S 2 0, 28 days IM NCT04569383
City of Hope, USA Replicating Viral Vector SARS-CoV-2 S and NP genes inserted into a sMVA vector 2 0, 28 days IM NCT04639466
Clover Biopharmaceuticals Inc./GSK/Dynavax Protein Subunit Native like Trimeric subunit Spike Protein vaccine 2 0, 21 days IM NCT04405908
Vaxine Pty Ltd/Medytox Protein Subunit Recombinant spike protein with Advax™ adjuvant 1 IM NCT04453852
University of Queensland/CSL/Seqirus Protein Subunit Molecular clamp stabilized Spike protein with MF59 adjuvant 2 0, 28 days IM ACTRN12620000674932p
ISRCTN51232965
Medigen Vaccine Biologics Corporation/NIAID/Dynavax Protein Subunit S-2P protein + CpG 1018 2 0, 28 days IM NCT04487210
Instituto Finlay de Vacunas, Cuba Protein Subunit rRBD produced in CHO-cell chemically conjugate to tetanus toxoid 2 0, 28 days IM IFV/COR/06
Instituto Finlay de Vacunas, Cuba Protein Subunit RBD + Adjuvant 2 0, 28 days IM IFV/COR/04
IFV/COR/05
FBRI SRC VB VECTOR, Rospotrebnadzor, Koltsovo Protein Subunit Peptide 2 0, 21 days IM NCT04527575
University Hospital Tuebingen Protein Subunit SARS-CoV-2 HLA-DR peptides 1 SC NCT04546841
COVAXX / United Biomedical Inc. Asia Protein Subunit Multitope peptide-based S1-RBD- protein vaccine 2 0, 28 days IM NCT04545749
Chinese Academy of Military Sciences Protein Subunit Subunit expressed in CHO cells 2 or 3 0, 14 days or 0,14, 28 days IM
Merck Sharp & Dohme/IAVI Replicating Viral Vector Replication-competent VSV delivering the SARS-CoV-2 Spike 1 IM NCT04569786
Institute Pasteur/Themis/Univ. of Pittsburg CVR/Merck Sharp & Dohme Replicating Viral Vector Measles-vector based 1 or 2 0, 28 days IM NCT04497298
Imperial College London RNA LNP-nCoVsaRNA 2 IM ISRCTN17072692
People's Liberation Army (PLA) Academy of Military Sciences/Walvax Biotech. RNA mRNA 2 0, 14 or 0, 28 days IM ChiCTR2000034112
ChiCTR2000039212


162 candidate vaccines in preclinical evaluation

Platform Type of candidate vaccine Developer Coronavirus target Current stage of clinical evaluation/regulatory status- Coronavirus
candidate 		Same platform for non-Coronavirus candidates
DNA DNA plasmids containing S-gene Biosun Pharmed SARS-CoV2 Pre-Clinical
DNA DNA plasmid vaccine Globe  Biotech Limited, Bangladesh SARS-CoV2 Pre-Clinical
DNA Plasmid DNA, nanostructured RBD National institute of Chemistry, Slovenia SARS-CoV2 Pre-Clinical
DNA DNA, engineered vaccine inserts compatible
with multiple delivery systems 		DIOSynVax Ltd / University of Cambridge SARS-CoV-2 and
Sarbeco-CoV 		Pre-Clinical
DNA DNA vaccine Ege University SARS-CoV2 Pre-Clinical
DNA DNA plasmid vaccine RBD&N Scancell/University of Nottingham/ Nottingham Trent University SARS-CoV2 Pre-Clinical
DNA DNA plasmid vaccine S,S1,S2,RBD &N National Research Centre, Egypt SARS-CoV2 Pre-Clinical
DNA DNA with electroporation Karolinska Institute / Cobra Biologics
(OPENCORONA Project) 		SARS-CoV2 Pre-Clinical
DNA DNA with electroporation Chula Vaccine Research Center SARS-CoV2 Pre-Clinical
DNA DNA Takis/Applied DNA Sciences/Evvivax SARS-CoV2 Pre-Clinical
DNA Plasmid DNA, Needle-Free Delivery Immunomic Therapeutics, Inc./EpiVax, Inc./PharmaJet SARS-CoV2 Pre-Clinical SARS
DNA DNA vaccine BioNet Asia SARS-CoV2 Pre-Clinical
DNA msDNA vaccine Mediphage Bioceuticals/University of Waterloo SARS-CoV2 Pre-Clinical
DNA DNA vaccine Entos Pharmaceuticals SARS-CoV2 Pre-Clinical
Inactivated Inactivated + Alum Shifa Pharmed SARS-CoV2 Pre-Clinical
Inactivated Inactivated Milad Pharmaceutics Co. SARS-CoV2 Pre-Clinical MMR, IPV
Inactivated Inactivated Zista Kian Azma Co. SARS-CoV2 Pre-Clinical MMR, IPV
Inactivated Inactivated Kocak Farma Ilac ve Kimya San. A.S. SARS-CoV2 Pre-Clinical
Inactivated Egg-based, inactivated, whole chimeric Newcastle Disease Virus (NDV) expressing membrane-anchored pre-fusion-stabilized trimeric SARS-CoV-2 S protein (Hexapro) +
CpG 1018 		Institute of Vaccines and Medical Biologicals (IVAC; Vietnam) / Dynavax
/ PATH 		SARS-CoV2 Pre-Clinical
Inactivated Egg-based, inactivated, whole chimeric Newcastle Disease Virus (NDV) expressing membrane-anchored pre-fusion-stabilized trimeric SARS-CoV-2 S protein (Hexapro) +
CpG 1018 		Government Pharmaceutical Organization (GPO; Thailand) / Dynavax / PATH SARS-CoV2 Pre-Clinical
Inactivated Egg-based, inactivated, whole chimeric Newcastle Disease Virus (NDV) expressing membrane-anchored pre-fusion-stabilized trimeric SARS-CoV-2 S protein (Hexapro) +
CpG 1018 		Institute Butantan (Brazil) / Dynavax / PATH SARS-CoV-2 Pre-clinical
Inactivated Inactivated + alum KM Biologics SARS-CoV2 Pre-Clinical JE, Zika
Inactivated Inactivated Selcuk University SARS-CoV2 Pre-Clinical
Inactivated Inactivated Erciyes University SARS-CoV2 Pre-Clinical
Inactivated Inactivated whole virus National Research Centre, Egypt SARS-CoV2 Pre-Clinical
Inactivated Inactivated SARS-CoV2 Pre-Clinical
Inactivated TBD Osaka University/ BIKEN/ NIBIOHN SARS-CoV2 Pre-Clinical
Inactivated Inactivated + CpG 1018 Sinovac/Dynavax SARS-CoV2 Pre-Clinical
Inactivated Inactivated + CpG 1018 Valneva/Dynavax SARS-CoV2 Pre-Clinical
Live Attenuated Virus Codon deoptimized live attenuated vaccines Mehmet Ali Aydinlar University / Acıbadem Labmed Health Services
A.S. 		SARS-CoV2 Pre-Clinical
Live Attenuated Virus Codon deoptimized live attenuated vaccines Indian Immunologicals Ltd/Griffith University SARS-CoV2 Pre-Clinical
Non Replicating Viral Vector Ad 5 vector for intranasal administration University of Helsinki & University of Eastern Finland SARS-CoV2 Pre-Clinical
Non Replicating Viral Vector Adenovirus Type 5 Vector Globe  Biotech Limited, Bangladesh SARS-CoV2 Pre-Clinical
Non-Replicating Viral Vector Sendai virus vector ID Pharma SARS-CoV2 Pre-Clinical
Non-Replicating Viral Vector Adenovirus-based Ankara University SARS-CoV2 Pre-Clinical
Non-Replicating Viral Vector Adeno-associated virus vector (AAVCOVID) Massachusetts Eye and Ear/Massachusetts General Hospital/AveXis SARS-CoV2 Pre-Clinical
Non-Replicating Viral Vector MVA encoded VLP GeoVax/BravoVax SARS-CoV2 Pre-Clinical LASV, EBOV, MARV, HIV
Non-replicating viral vector MVA-S encoded DZIF – German Center for Infection Research/IDT Biologika GmbH SARS-CoV2 Pre-clinical Many
Non-replicating viral vector MVA-S IDIBAPS-Hospital Clinic, Spain SARS-CoV2 Pre-clinical
Non-Replicating Viral Vector Intranasal Ad5 vaccine encoding RBD Altimmune, Inc. SARS-CoV2 IND filed Influenza (NasoVAX), Anthrax
(NasoShield)
Non-Replicating Viral Vector Adeno5-based Erciyes University SARS-CoV2 Pre-Clinical
Non-Replicating Viral Vector Ad5 S (GREVAX™ platform) Greffex SARS-CoV2 Pre-Clinical MERS
Non-Replicating Viral Vector Oral Ad5 S Stabilitech Biopharma Ltd SARS-CoV2 Pre-Clinical Zika, VZV, HSV-2 and Norovirus
Non-Replicating Viral Vector adenovirus-based  +  HLA-matched peptides Valo Therapeutics Ltd Pan-Corona Pre-Clinical
Non-Replicating Viral Vector Vaxart SARS-CoV2 Pre-Clinical InfA, CHIKV, LASV, NORV; EBOV, RVF, HBV, VEE
Non-Replicating Viral Vector MVA expressing structural proteins Centro Nacional Biotecnología (CNB-CSIC), Spain SARS-CoV2 Pre-Clinical Multiple candidates
Non-Replicating Viral Vector parainfluenza virus 5 (PIV5)-based vaccine
expressing the spike protein 		University of Georgia/University of Iowa SARS-CoV2 Pre-Clinical MERS
Non-Replicating Viral Vector Recombinant deactivated rabies virus
containing S1 		Bharat Biotech/Thomas Jefferson University SARS-CoV2 Pre-Clinical HeV, NiV, EBOV, LASSA, CCHFV, MERS
Non-Replicating Viral Vector Influenza A H1N1 vector National Research Centre, Egypt SARS-CoV2 Pre-Clinical
Non-Replicating Viral Vector Newcastle disease virus expressing S Icahn School of Medicine at Mount Sinai SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant spike with adjuvant Iran SARS-CoV2 Pre-Clinical Multiple candidates
Protein Subunit Recombinant S protein produced in BEVS Tampere University SARS-CoV2 Pre-Clinical
Protein Subunit RBD protein delivered in mannose-
conjugated chitosan nanoparticle 		Ohio State University / Kazakh National Agrarian University SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant spike protein with Essai O/W
1849101 adjuvant 		Kazakh National Agrarian University SARS-CoV2 Pre-Clinical
Protein Subunit Peptides Neo7Logic SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant spike protein with Essai O/W
1849101 adjuvant 		Kazakh National Agrarian University, Kazakhstan / National Scientific
Center for Especially Dangerous Infections 		SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant S protein Max-Planck-Institute of Colloids and Interfaces SARS-CoV2 Pre-Clinical
Protein Subunit RBD protein (baculovirus production) + FAR-
Squalene adjuvant 		Farmacológicos Veterinarios SAC (FARVET SAC) / Universidad Peruana
Cayetano Heredia (UPCH) 		SARS-CoV2 Pre-Clinical
Protein Subunit Protein Subunit Research Institute for Biological Safety Problems, Rep of Kazakhstan SARS-CoV2 Pre-Clinical
Protein Subunit RBD-protein Mynvax SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant S protein Izmir Biomedicine and Genome Center SARS-CoV2 Pre-Clinical
Protein Subunit Peptide + novel adjuvant Bogazici University SARS-CoV2 Pre-Clinical
Protein Subunit S subunit intranasal liposomal formulation
with GLA/3M052 adjs. 		University of Virginia SARS-CoV2 Pre-Clinical
Protein Subunit S-Protein (Subunit) + Adjuvant, E coli based
Expression 		Helix Biogen Consult, Ogbomoso & Trinity Immonoefficient Laboratory,
Ogbomoso, Oyo State, Nigeria. 		SARS-CoV2 Pre-Clinical
Protein Subunit Protein Subunit S,N,M&S1 protein National Research Centre, Egypt SARS-CoV2 Pre-Clinical
Protein Subunit Protein Subunit University of San Martin and CONICET, Argentina SARS-CoV2 Pre-Clinical
Protein Subunit RBD protein fused with Fc of IgG + Adj. Chulalongkorn University/GPO, Thailand SARS-CoV2 Pre-Clinical
Protein Subunit Capsid-like Particle AdaptVac (PREVENT-nCoV consortium) SARS-CoV2 Pre-Clinical
Protein Subunit Drosophila S2 insect cell expression system
VLPs 		ExpreS2ion SARS-CoV2 Pre-Clinical
Protein Subunit Peptide antigens formulated in LNP IMV Inc SARS-CoV2 Pre-Clinical
Protein Subunit S protein WRAIR/USAMRIID SARS-CoV2 Pre-Clinical
Protein Subunit S protein +Adjuvant National Institute of Infectious Disease, Japan/Shionogi/UMN Pharma SARS-CoV2 Pre-Clinical Influenza
Protein Subunit VLP-recombinant protein + Adjuvant Osaka University/ BIKEN/  National Institutes of Biomedical Innovation,
Japan 		SARS-CoV2 Pre-Clinical
Protein Subunit microneedle arrays S1 subunit Univ. of Pittsburgh SARS-CoV2 Pre-Clinical MERS
Protein Subunit Peptide Vaxil Bio SARS-CoV2 Pre-Clinical
Protein Subunit Peptide Flow Pharma Inc SARS-CoV2 Pre-Clinical Ebola, Marburg, HIV, Zika, Influenza, HPV therapeutic vaccine, BreastCA
vaccine
Protein Subunit S protein AJ Vaccines SARS-CoV2 Pre-Clinical
Protein Subunit Ii-Key peptide Generex/EpiVax SARS-CoV2 Pre-Clinical Influenza, HIV, SARS-CoV
Protein Subunit S protein EpiVax/Univ. of Georgia SARS-CoV2 Pre-Clinical H7N9
Protein Subunit Protein Subunit EPV-CoV-19 EpiVax SARS-CoV2 Pre-Clinical
Protein Subunit gp-96 backbone Heat Biologics/Univ. Of Miami SARS-CoV2 Pre-Clinical NSCLC, HIV, malaria, Zika
Protein Subunit Subunit vaccine FBRI SRC VB VECTOR, Rospotrebnadzor, Koltsovo SARS-CoV2 Pre-Clinical
Protein Subunit S1 or RBD protein Baylor College of Medicine SARS-CoV2 Pre-Clinical SARS
Protein Subunit Subunit protein, plant produced iBio/CC-Pharming SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant protein, nanoparticles (based
on S-protein and other epitopes) 		Saint-Petersburg scientific research institute of vaccines and serums SARS-CoV2 Pre-Clinical
Protein Subunit COVID-19 XWG-03
truncated S (spike) proteins 		Innovax/Xiamen Univ./GSK SARS-CoV2 Pre-Clinical HPV
Protein Subunit Adjuvanted microsphere peptide VIDO-InterVac, University of Saskatchewan SARS-CoV2 Pre-Clinical
Protein Subunit Synthetic Long Peptide Vaccine candidate for
S and M proteins 		OncoGen SARS-CoV2 Pre-Clinical
Protein Subunit Oral  E. coli-based protein expression system
of S and N proteins 		MIGAL Galilee Research Institute SARS-CoV2 Pre-Clinical
Protein Subunit Nanoparticle vaccine LakePharma, Inc. SARS-CoV2 Pre-Clinical
Protein Subunit Plant-based subunit
(RBD-Fc + Adjuvant) 		Baiya Phytopharm/ Chula Vaccine Research Center SARS-CoV2 Pre-Clinical
Protein Subunit OMV-based vaccine Quadram Institute Biosciences SARS-CoV2 Pre-Clinical Flu A, plague
Protein Subunit OMV-based vaccine BiOMViS Srl/Univ. of Trento SARS-CoV2 Pre-Clinical
Protein subunit structurally modified spherical particles of
the tobacco mosaic virus (TMV) 		Lomonosov Moscow State University SARS-CoV2 Pre-Clinical rubella, rotavirus
Protein Subunit Spike-based University of Alberta SARS-CoV2 Pre-Clinical Hepatitis C
Protein Subunit Recombinant S1-Fc fusion protein AnyGo Technology SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant protein Yisheng Biopharma SARS-CoV2 Pre-Clinical
Protein Subunit Recombinant S protein in IC-BEVS Vabiotech SARS-CoV2 Pre-Clinical
Protein Subunit Orally delivered, heat stable subunit Applied Biotechnology Institute, Inc. SARS-CoV2 Pre-Clinical
Protein Subunit Peptides derived from Spike protein Axon Neuroscience SE SARS-CoV2 Pre-Clinical
Protein Subunit Protein Subunit MOGAM Institute for Biomedical Research, GC Pharma SARS-CoV2 Pre-Clinical
Protein Subunit RBD-based Neovii/Tel Aviv University SARS-CoV2 Pre-Clinical
Protein Subunit Outer Membrane Vesicle (OMV)-subunit Intravacc/Epivax SARS-CoV2 Pre-Clinical
Protein Subunit Outer Membrane Vesicle(OMV)-peptide Intravacc/Epivax SARS-CoV2 Pre-Clinical
Protein Subunit Spike-based (epitope screening) ImmunoPrecise/LiteVax BV SARS-CoV2 Pre-Clinical
Protein Subunit Spiked-based Nanografi Nano Technology, Middle East Technical University, Ankara
University, 		SARS-CoV2 Pre-Clinical
Replicating Bacteria Vector Oral Salmonella enteritidis (3934Vac) based
protein expression system of RBD 		Farmacológicos Veterinarios SAC (FARVET SAC) / Universidad Peruana
Cayetano Heredia (UPCH) 		SARS-CoV2 Pre-Clinical
Replicating Viral Vector Intranasal Newcastle disease virus vector
(rNDV-FARVET) expressing RBD 		Farmacológicos Veterinarios SAC (FARVET SAC) / Universidad Peruana
Cayetano Heredia (UPCH) 		SARS-CoV2 Pre-Clinical
Replicating Viral Vector YF17D Vector KU Leuven SARS-CoV2 Pre-Clinical
Replicating Viral Vector Measles Vector Cadila Healthcare Limited SARS-CoV2 Pre-Clinical
Replicating Viral Vector Measles Vector FBRI SRC VB VECTOR, Rospotrebnadzor, Koltsovo SARS-CoV2 Pre-Clinical
Replicating Viral Vector Measles Virus (S, N targets) DZIF – German Center for Infection Research/CanVirex AG SARS-CoV2 Pre-clinical Zika, H7N9, CHIKV
Replicating Viral Vector Horsepox vector expressing S protein Tonix Pharma/Southern Research SARS-CoV2 Pre-Clinical Smallpox, monkeypox
Replicating Viral Vector Live viral vectored vaccine based on attenuated influenza virus backbone (intranasal) BiOCAD and IEM SARS-CoV2 Pre-Clinical Influenza
Replicating Viral Vector Recombinant vaccine based on Influenza A virus, for the prevention of COVID-19 (intranasal) FBRI SRC VB VECTOR, Rospotrebnadzor, Koltsovo SARS-CoV2 Pre-Clinical Influenza
Replicating Viral Vector Attenuated Influenza expressing
an antigenic portion of the Spike protein 		Fundação Oswaldo Cruz and Instituto Buntantan SARS-CoV2 Pre-Clinical Influenza
Replicating Viral Vector Influenza vector expressing RBD University of Hong Kong SARS-CoV2 Pre-Clinical
Replicating Viral Vector Replicating VSV vector-based DC-targeting University of Manitoba SARS-CoV2 Pre-Clinical
Replicating Viral Vector VSV-S University of Western Ontario SARS-CoV2 Pre-Clinical HIV, MERS
Replicating Viral Vector VSV-S Aurobindo SARS-CoV2 Pre-Clinical
Replicating Viral Vector VSV vector FBRI SRC VB VECTOR, Rospotrebnadzor, Koltsovo SARS-CoV2 Pre-Clinical
Replicating Viral Vector M2-deficient single replication (M2SR)
influenza vector 		UW–Madison/FluGen/Bharat Biotech SARS-CoV2 Pre-Clinical influenza
Replicating Viral Vector Newcastle disease virus vector (NDV-SARS-
CoV-2/Spike) 		Intravacc/ Wageningen Bioveterinary Research/Utrecht Univ. SARS-CoV2 Pre-Clinical
Replicating Viral Vector Avian paramyxovirus vector (APMV) The Lancaster University, UK SARS-CoV2 Pre-Clinical
RNA mRNA Providence Therapeutics SARS-CoV2 Pre-Clinical
RNA mRNA Cell Tech Pharmed SARS-CoV2 Pre-Clinical
RNA mRNA ReNAP Co. SARS-CoV2 Pre-Clinical
RNA D614G variant LNP-encapsulated mRNA Globe Biotech Ltd SARS-CoV2 Pre-Clinical
RNA saRNA formulated in a NLC Infectious Disease Research Institute/ Amyris, Inc. SARS-CoV2 Pre-Clinical
RNA LNP-encapsulated mRNA encoding S Max-Planck-Institute of Colloids and Interfaces SARS-CoV2 Pre-Clinical
RNA Self-amplifying RNA Gennova SARS-CoV2 Pre-Clinical
RNA mRNA Selcuk University SARS-CoV2 Pre-Clinical
RNA LNP-mRNA Translate Bio/Sanofi Pasteur SARS-CoV2 Pre-Clinical
RNA LNP-mRNA CanSino Biologics/Precision NanoSystems SARS-CoV2 Pre-Clinical
RNA LNP-encapsulated mRNA  cocktail encoding
VLP 		Fudan University/ Shanghai JiaoTong University/RNACure Biopharma SARS-CoV2 Pre-Clinical
RNA LNP-encapsulated mRNA encoding RBD Fudan University/ Shanghai JiaoTong University/RNACure Biopharma SARS-CoV2 Pre-Clinical
RNA Replicating Defective SARS-CoV-2 derived
RNAs 		Centro Nacional Biotecnología (CNB-CSIC), Spain SARS-CoV2 Pre-Clinical
RNA LNP-encapsulated mRNA University of Tokyo/ Daiichi-Sankyo SARS-CoV2 Pre-Clinical MERS
RNA Liposome-encapsulated mRNA BIOCAD SARS-CoV2 Pre-Clinical
RNA Several mRNA candidates RNAimmune, Inc. SARS-CoV2 Pre-Clinical
RNA mRNA FBRI SRC VB VECTOR, Rospotrebnadzor, Koltsovo SARS-CoV2 Pre-Clinical
RNA mRNA China CDC/Tongji University/Stermina SARS-CoV2 Pre-Clinical
RNA LNP-mRNA Chula Vaccine Research Center/University of Pennsylvania SARS-CoV2 Pre-Clinical
RNA mRNA in an intranasal delivery system eTheRNA SARS-CoV2 Pre-Clinical
RNA mRNA Greenlight Biosciences SARS-CoV2 Pre-Clinical
RNA mRNA IDIBAPS-Hospital Clinic, Spain SARS-CoV2 Pre-Clinical
T-cell based CD8 T cell peptide targeting (S, M, N) and
(NSPs) SARS-CoV-2 proteins 		OSE immunotherapeutics SARS-CoV2 Pre-Clinical
VLP Plant derived VLP Shiraz University SARS-CoV2 Pre-Clinical
VLP VLPs produced in BEVS Tampere University SARS-CoV2 Pre-Clinical
VLP VLP Max Planck Institute for Dynamics of Complex Technical Systems SARS-CoV2 Pre-Clinical
VLP Virus-like particle-based Dendritic Cell(DC)-
targeting vaccine 		University of Manitoba SARS-CoV2 Pre-Clinical
VLP VLP Bezmialem Vakif University SARS-CoV2 Pre-Clinical
VLP VLP Middle East Technical University SARS-CoV2 Pre-Clinical
VLP Enveloped Virus-Like Particle (eVLP) VBI Vaccines Inc. SARS-CoV-2,
SARS-CoV,
MERS-CoV 		Pre-Clinical CMV, GBM, Zika
VLP S protein integrated in HIV VLPs IrsiCaixa AIDS Research/IRTA-CReSA/Barcelona Supercomputing
Centre/Grifols 		SARS-CoV2 Pre-Clinical
VLP VLP + Adjuvant Mahidol University/ The Government Pharmaceutical Organization
(GPO)/Siriraj Hospital 		SARS-CoV2 Pre-Clinical
VLP Virus-like particles,  lentivirus and
baculovirus vehicles 		Navarrabiomed, Oncoimmunology group SARS-CoV2 Pre-Clinical
VLP Virus-like particle, based on RBD displayed
on virus-like particles 		Saiba GmbH SARS-CoV2 Pre-Clinical
VLP ADDomerTM multiepitope display Imophoron Ltd and Bristol University’s Max Planck Centre SARS-CoV2 Pre-Clinical
VLP Unknown Doherty Institute SARS-CoV2 Pre-Clinical
VLP VLP OSIVAX SARS-CoV1
SARS-CoV2 		Pre-Clinical
VLP eVLP ARTES Biotechnology SARS-CoV2 Pre-Clinical malaria
VLP VLPs peptides/whole virus Univ. of Sao Paulo SARS-CoV2 Pre-Clinical








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