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Summary of RARB Gene

Official Symbol RARB provided by HGNC
Official Full Name retinoic acid receptor beta provided by HGNC
Primary source HGNC:HGNC:9865
See related Ensembl:ENSG00000077092  MIM:180220
Gene type protein coding
RefSeq status REVIEWED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as HAP; RRB2; NR1B2; MCOPS12; RARbeta1
Summary This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression Ubiquitous expression in placenta (RPKM 7.0), urinary bladder (RPKM 5.7) and 22 other tissues See more
Orthologs mouse


RARB Gene - Genemedi's Promise-ORFTM

Product Name Contents Price(In USD) Qty (Quantity) Sum(In USD)
Human RARB Lentivirus plasmid (NM_000965) Species: human
Product Type: Lentivirus plasmid (overexpression)
Fluorescent Label: GFP+PURO
Fusion Tag: 3xflag
Promoter: CMV
Resistance: Amplicin
size: 5ug
777
Mouse Rarb Lentivirus plasmid (NM_001289761.1) Species: mouse
Product Type: Lentivirus plasmid (overexpression)
Fluorescent Label: GFP+PURO
Fusion Tag: 3xflag
Promoter: CMV
Resistance: Amplicin
size: 5ug
777
Optional Choice Plasmid Validation(qPCR) 500
Optional Choice Plasmid Validation(Western Blot) 500
Shipping Cost: 169.00
Total:
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Function of RARB Gene


Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).


Expression of RARB Gene


Tissue specificity

Expressed in aortic endothelial cells (at protein level).

Sample Image:

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Interaction of RARB Gene


Subunit structure

Homodimer (By similarity). Heterodimer; with a RXR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Heterodimerizes (via NR LBD) with RXRA (PubMed:29021580).

Interacts weakly with NCOR2 (PubMed:12554770).

Interacts with MCL1, BCL2A1 and BAX.

Binary interactions

P10826 has binary interactions with 5 proteins

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