RARB Gene (Retinoic Acid Receptor Beta)
Summary of RARB Gene
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RARB provided by HGNC |
|
retinoic acid receptor beta provided by HGNC |
| HGNC:HGNC:9865 |
| Ensembl:ENSG00000077092 MIM:180220 |
| protein coding |
| REVIEWED |
| Homo sapiens |
| Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| HAP; RRB2; NR1B2; MCOPS12; RARbeta1 |
| This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| Ubiquitous expression in placenta (RPKM 7.0), urinary bladder (RPKM 5.7) and 22 other tissues See more |
| mouse |
Product Name | Contents | Price(In USD) | Qty (Quantity) | Sum(In USD) |
---|---|---|---|---|
Human RARB Lentivirus plasmid (NM_000965) |
Species: human Product Type: Lentivirus plasmid (overexpression) Fluorescent Label: GFP+PURO Fusion Tag: 3xflag Promoter: CMV Resistance: Amplicin size: 5ug |
777 | ||
Mouse Rarb Lentivirus plasmid (NM_001289761.1) |
Species: mouse Product Type: Lentivirus plasmid (overexpression) Fluorescent Label: GFP+PURO Fusion Tag: 3xflag Promoter: CMV Resistance: Amplicin size: 5ug |
777 | ||
Optional Choice | Plasmid Validation(qPCR) | 500 | ||
Optional Choice | Plasmid Validation(Western Blot) | 500 | ||
Shipping Cost: | 169.00 | |||
Total: | ||||
Function of RARB Gene
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Expression of RARB Gene
Interacts weakly with NCOR2 (PubMed:12554770). Interacts with MCL1, BCL2A1 and BAX.
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