Anti-AUHM/ AUH functional antibody

Anti-AUHM/ AUH functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to AUH/AUH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1534-Ab-1/ GM-Tg-hg-SE1534-Ab-2Anti-Human AUH monoclonal antibodyHuman
GM-Tg-rg-SE1534-Ab-1/ GM-Tg-rg-SE1534-Ab-2Anti-Rat AUH monoclonal antibodyRat
GM-Tg-mg-SE1534-Ab-1/ GM-Tg-mg-SE1534-Ab-2Anti-Mouse AUH monoclonal antibodyMouse
GM-Tg-cynog-SE1534-Ab-1/ GM-Tg-cynog-SE1534-Ab-2Anti-Cynomolgus/ Rhesus macaque AUH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1534-Ab-1/ GM-Tg-felg-SE1534-Ab-2Anti-Feline AUH monoclonal antibodyFeline
GM-Tg-cang-SE1534-Ab-1/ GM-Tg-cang-SE1534-Ab-2Anti-Canine AUH monoclonal antibodyCanine
GM-Tg-bovg-SE1534-Ab-1/ GM-Tg-bovg-SE1534-Ab-2Anti-Bovine AUH monoclonal antibodyBovine
GM-Tg-equg-SE1534-Ab-1/ GM-Tg-equg-SE1534-Ab-2Anti-Equine AUH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1534-Ab-1/ GM-Tg-hg-SE1534-Ab-2; GM-Tg-rg-SE1534-Ab-1/ GM-Tg-rg-SE1534-Ab-2;
GM-Tg-mg-SE1534-Ab-1/ GM-Tg-mg-SE1534-Ab-2; GM-Tg-cynog-SE1534-Ab-1/ GM-Tg-cynog-SE1534-Ab-2;
GM-Tg-felg-SE1534-Ab-1/ GM-Tg-felg-SE1534-Ab-2; GM-Tg-cang-SE1534-Ab-1/ GM-Tg-cang-SE1534-Ab-2;
GM-Tg-bovg-SE1534-Ab-1/ GM-Tg-bovg-SE1534-Ab-2; GM-Tg-equg-SE1534-Ab-1/ GM-Tg-equg-SE1534-Ab-2
Products NameAnti-AUH monoclonal antibody
Formatmab
Target NameAUH
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AUH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1534-Ag-1Recombinant multi-species AUHM/ AUH protein


    Target information

    Target IDGM-SE1534
    Target NameAUH
    Gene ID549,11992,361215,704542,476348,101096361,614716,100064392
    Gene Symbol and SynonymsAUH
    Uniprot AccessionQ13825,F1LU71
    Uniprot Entry NameAUHM_HUMAN,AUHM_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseProstate Cancer
    Gene EnsemblENSG00000148090
    Target ClassificationN/A

    The target: AUH, gene name: AUH, also named as . This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.