Diagnostic recombinant Heparin-binding protein (HBP) antigens (recombinant Heparin-binding protein (HBP) ) protein) for inflammation/autoimmune/ inflammatory disease HBP detection in positive control, ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Catalog Number: GMP-HBP-Ag
The incidence of sepsis increases with ageing, rise in cancer incidence and popularity of invasive medical operations.1 2 Rapid detection and optimised treatment are the keys to successful treatment of sepsis.3 To facilitate earlier recognition and more timely management of patients with sepsis or those at risk of developing the condition, the European Society of Intensive Care Medicine and Society of Critical Care Medicine published new diagnostic criteria for sepsis and septic shock.4 Nevertheless, due to time delay, low sensitivity and lack of specificity,5 the existing diagnosis indicators such as microbial culture, complete blood count, and levels of procalcitonin (PCT) and C reactive protein (CRP) are inadequate for timely clinical diagnosis of sepsis and septic shock.
Heparin-binding protein (HBP) is precomposed and mainly exists in the azurophilic granules (almost 74% in content) and secretory vesicles (almost 18% in content) of neutrophils. Azurophilic granules show low tendency to be released from cells, and they are only released when neutrophils infiltrate tissues.6 The release of easily mobilised HBP from secretory vesicles has important functions during early events in inflammatory processes. HBP works by activating various cell types.7 Previous studies have shown that the plasma HBP level is significantly elevated in sepsis combined with organ dysfunction, which is the best probe for the progression of sepsis.3 8 Given the capacity of HBP to identify infection and vascular leakage in patients, it is also an interesting candidate marker to monitor patients with sepsis and septic shock.
Genemedi produces core diagnostic ingredients for test of inflammation/autoimmune/
inflammatory disease and related syndrome. GeneMedi offers paired diagnostics grade Heparin-binding protein (HBP) antibodies (monoclonal antibody, mab) and Heparin-binding protein (HBP) antigens for inflammation/autoimmune/
inflammatory disease rapid test kit of Heparin-binding protein (HBP) testing in positive control, ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
All the antibodies and antigens for inflammation/autoimmune/
inflammatory disease test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibodies can act as a capture antibody and detection antibody. The antigens can be used for antibodies rapid test of inflammation/autoimmune/
inflammatory disease.
Order information
Catalog No. | Size | Price(In USD) | Qty (Quantity) | Sum(In USD) |
---|---|---|---|---|
GMP-HBP-Ag | Size:1mg | 3090 | ||
GMP-HBP-Ag | Size:10mg | 21890 | ||
GMP-HBP-Ag | Size:100mg | 148000 | ||
GMP-HBP-Ag | ≥100mg | Inquiry | ||
Shipping Cost: | 760.00 | |||
Total: | ||||
Description
Cat No. | GMP-HBP-Ag |
Product Name | Recombinant Heparin-binding protein (HBP, His Tag) |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Heparin-binding protein (HBP) Antibody Binding, Immunogen in Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT |
Tag | His |
Products description | Recombinant Heparin-binding protein (HBP, His Tag) is produced by E.coli expression system with a 6His tag. |
Specics | NA |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | positive control,ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
GeneMedi’s IL-6 (Interleukin 6) Antibody Pair Validation In Sandwich ELISA Data Post Download
Figure. GeneMedi's IL-6 antibody pair validation with IL-6 antigen (IL-6-Ag01) in sandwich ELISA.
Abbreviation | Description |
IL-6-Ab01 | GMP-h-IL-6-Ab01 |
IL-6-Ab02 | GMP-h-IL-6-Ab02 |
IL6-Ab03 | GMP-h-IL6-Ab03 |
IL-6-Ag01 | GMP-h-IL-6-Ag01 |
Diagnostic antibodies and antigens for Inflammation/autoimmune/inflammatory diseases testing-IL-6, PCT, CRP, SAA, IFNγ, AQP4, HBP, MOG, S100-A9, TPO, SAA1, TNFα,α-defensin 1, α-defensin 5
Inflammation/autoimmune/inflammatory diseases occur when the immune system attacks the normal tissue within joints, vasculature, and other organ systems, causing inflammation, pain, diminished mobility, fatigue, and other non-specific symptoms. The strong overlap of signs and symptoms among the autoimmune diseases can lead to delays in diagnosis and appropriate treatment. However, immunodiagnostics has been developed to detect the inflammation/autoimmune/inflammatory disease such as ankylosing spondylitis, bacterial infections, bacterial meningitis, cerebrovascular diseases, crohn's disease, fungal infection, graves' disease, inflammatory amyloidosis, inflammatory bowel disease, mog antibody disease, osteomyelitis, rheumatoid arthritis, sepsis, respiratory illnesses and so on at an early stage. Biomarkers have been developed to detect this autoimmune disease at an early stage. Detecting the quantity of marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
IL-6
PCT
CRP
SAA
IFNγ
AQP4
HBP
MOG
S100-A9
TPO
SAA1
TNFα
MPA
CCP
alpha defensin 1
alpha defensin 5
- GENEMEDI
- Email: [email protected] [email protected]
- Telephone: +86-21-50478399 Fax: 86-21-50478399
- Privacy Policy
- TECHNICAL SUPPORT
- Product FAQs
- Technical manuals
- Publications
- Email: [email protected]