Diagnostic recombinant Heparin-binding protein (HBP) antigens (recombinant Heparin-binding protein (HBP) ) protein) for inflammation/autoimmune/ inflammatory disease HBP detection in positive control, ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

Catalog Number: GMP-HBP-Ag

The incidence of sepsis increases with ageing, rise in cancer incidence and popularity of invasive medical operations.1 2 Rapid detection and optimised treatment are the keys to successful treatment of sepsis.3 To facilitate earlier recognition and more timely management of patients with sepsis or those at risk of developing the condition, the European Society of Intensive Care Medicine and Society of Critical Care Medicine published new diagnostic criteria for sepsis and septic shock.4 Nevertheless, due to time delay, low sensitivity and lack of specificity,5 the existing diagnosis indicators such as microbial culture, complete blood count, and levels of procalcitonin (PCT) and C reactive protein (CRP) are inadequate for timely clinical diagnosis of sepsis and septic shock. Heparin-binding protein (HBP) is precomposed and mainly exists in the azurophilic granules (almost 74% in content) and secretory vesicles (almost 18% in content) of neutrophils. Azurophilic granules show low tendency to be released from cells, and they are only released when neutrophils infiltrate tissues.6 The release of easily mobilised HBP from secretory vesicles has important functions during early events in inflammatory processes. HBP works by activating various cell types.7 Previous studies have shown that the plasma HBP level is significantly elevated in sepsis combined with organ dysfunction, which is the best probe for the progression of sepsis.3 8 Given the capacity of HBP to identify infection and vascular leakage in patients, it is also an interesting candidate marker to monitor patients with sepsis and septic shock.

Genemedi produces core diagnostic ingredients for test of inflammation/autoimmune/ inflammatory disease and related syndrome. GeneMedi offers paired diagnostics grade Heparin-binding protein (HBP) antibodies (monoclonal antibody, mab) and Heparin-binding protein (HBP) antigens for inflammation/autoimmune/ inflammatory disease rapid test kit of Heparin-binding protein (HBP) testing in positive control, ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

All the antibodies and antigens for inflammation/autoimmune/ inflammatory disease test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibodies can act as a capture antibody and detection antibody. The antigens can be used for antibodies rapid test of inflammation/autoimmune/ inflammatory disease.

Order information

Catalog No. Size Price(In USD) Qty (Quantity) Sum(In USD)
GMP-HBP-Ag Size:1mg 3090
GMP-HBP-Ag Size:10mg 21890
GMP-HBP-Ag Size:100mg 148000
GMP-HBP-Ag ≥100mg Inquiry
Shipping Cost: 760.00
Total:

For more than 100mg, click here for inquiry. >>


Description


Cat No. GMP-HBP-Ag
Product Name Recombinant Heparin-binding protein (HBP, His Tag)
Expression platform E.coli
IsotypesRecombinant Antigen
Bioactivity validationHeparin-binding protein (HBP) Antibody Binding, Immunogen in Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
TagHis
Products descriptionRecombinant Heparin-binding protein (HBP, His Tag) is produced by E.coli expression system with a 6His tag.
SpecicsNA
PurityPurity: ≥95% (SDS-PAGE)
Application positive control,ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


GeneMedi’s IL-6 (Interleukin 6) Antibody Pair Validation In Sandwich ELISA     pdf downloadData Post Download



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Figure. GeneMedi's IL-6 antibody pair validation with IL-6 antigen (IL-6-Ag01) in sandwich ELISA.
Abbreviation Description
IL-6-Ab01 GMP-h-IL-6-Ab01
IL-6-Ab02 GMP-h-IL-6-Ab02
IL6-Ab03 GMP-h-IL6-Ab03
IL-6-Ag01 GMP-h-IL-6-Ag01



Diagnostic antibodies and antigens for Inflammation/autoimmune/inflammatory diseases testing-IL-6, PCT, CRP, SAA, IFNγ, AQP4, HBP, MOG, S100-A9, TPO, SAA1, TNFα，α-defensin 1, α-defensin 5

Inflammation/autoimmune/inflammatory diseases occur when the immune system attacks the normal tissue within joints, vasculature, and other organ systems, causing inflammation, pain, diminished mobility, fatigue, and other non-specific symptoms. The strong overlap of signs and symptoms among the autoimmune diseases can lead to delays in diagnosis and appropriate treatment. However, immunodiagnostics has been developed to detect the inflammation/autoimmune/inflammatory disease such as ankylosing spondylitis, bacterial infections, bacterial meningitis, cerebrovascular diseases, crohn's disease, fungal infection, graves' disease, inflammatory amyloidosis, inflammatory bowel disease, mog antibody disease, osteomyelitis, rheumatoid arthritis, sepsis, respiratory illnesses and so on at an early stage. Biomarkers have been developed to detect this autoimmune disease at an early stage. Detecting the quantity of marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

IL-6 PCT CRP SAA IFNγ AQP4 HBP MOG S100-A9 TPO SAA1 TNFα MPA CCP alpha defensin 1 alpha defensin 5