Cow casein antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Cow casein antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Cow casein

OVA-Cow casein

Anti-Cow casein mouse monoclonal antibody

Anti-Cow casein human monoclonal antibody

Reference

Validation Data

Click to get more Data / Case study about the product.

Biomarker Information

Cow Casein Description:

Cow casein, a prevalent protein component found in the milk of cattle, is a complex and multifaceted molecule that plays a pivotal role in various aspects of dairy product development and serves as a fundamental protein source in the human diet. In the context of allergens, cow casein garners attention due to its potential to induce allergic reactions in susceptible individuals. To delve deeper into its characteristics, cow casein is a family of proteins, with beta-casein being one of its notable variants. It is a globular protein, existing in micellar form within milk, and is rich in essential amino acids, making it a valuable nutritional component.

Composition and Molecular Structure:

Cow casein is primarily composed of amino acid residues, with proline-rich regions, which contribute to its unique structural properties. This protein is distinguished by its intricate network of disulfide bonds and its ability to form stable micelles in milk, essential for the emulsification and stabilization of milk fat globules. Beta-casein, a significant subtype of cow casein, further diversifies the protein's structural characteristics, with A1 and A2 beta-casein being the two primary genetic variants, each having distinct properties.

Role in Allergens:

Cow casein assumes significance as an allergenic protein due to its immunogenic properties, which can elicit allergic responses in individuals with milk-related sensitivities. Those with milk allergies or lactose intolerance are at risk of experiencing adverse immune reactions upon exposure to cow casein. These allergic reactions span a spectrum of symptoms, including skin manifestations such as hives, gastrointestinal distress, respiratory complications, and in severe cases, life-threatening anaphylaxis.

Immunogenic Properties:

Cow casein's immunogenicity stems from its ability to act as an antigen, provoking immune responses in susceptible individuals. When ingested by individuals with sensitivities, cow casein may be recognized as foreign by the immune system. This recognition can lead to the production of antibodies and activation of immune cells, resulting in the release of histamines and other inflammatory molecules, triggering the characteristic symptoms of an allergic reaction.

Reasons to Measure Cow Casein:

The precise measurement of cow casein is essential for a multitude of reasons, particularly relevant to a biopharmaceutical company specializing in anti-small molecules antibodies and small molecules competitive antigens:

a. Allergen Detection and Labeling:

Accurate quantification of cow casein content is paramount for the identification of its presence in various food products, pharmaceuticals, and consumer goods. This information is vital for allergen labeling compliance, ensuring that products are properly labeled for individuals prone to milk allergies. By adhering to stringent labeling regulations, companies can safeguard the health and well-being of consumers with milk-related sensitivities.

b. Quality Control in Dairy Industry:

In the manufacturing processes of dairy products such as cheese, yogurt, and milk-based beverages, meticulous monitoring of cow casein levels is essential. Cow casein contributes to the textural and functional properties of these products. Maintaining consistent cow casein levels ensures product quality, texture, and taste, meeting consumer expectations. Furthermore, it ensures adherence to regulatory standards, preventing variations that could compromise product integrity.

c. Pharmaceutical Development and Research:

Cow casein finds utility in various pharmaceutical applications, such as a carrier molecule in conjugates used for immunogen preparation. Accurate quantification of cow casein concentration is fundamental in the development and optimization of these products. Researchers rely on precise measurements to ensure that immunogens and conjugates are prepared with the desired concentration of cow casein, leading to effective research outcomes and reliable diagnostics.

d. Safety Assessment in Pharmaceuticals:

For individuals participating in clinical trials or using pharmaceutical formulations containing cow casein-derived components, measuring cow casein levels is imperative. This assessment aids in evaluating the safety of products, assessing their allergenic potential, and mitigating the risk of adverse reactions. By quantifying cow casein content, pharmaceutical companies can ensure the safety and well-being of patients and comply with rigorous regulatory requirements.

e. Research and Development of Allergen-Free Products:

The accurate measurement of cow casein is crucial in the research and development of allergen-free or hypoallergenic food products. Companies working to cater to individuals with milk allergies rely on precise quantification to create safe alternatives while maintaining the desired taste, texture, and nutritional qualities of traditional dairy products.

In summary, cow casein, a complex protein with structural diversity, assumes a significant role in allergen detection, food and pharmaceutical quality assurance, research and development, and safety assessment. Its precise measurement is indispensable for ensuring product safety and efficacy, adhering to regulatory standards, and meeting the diverse needs of consumers and researchers alike.

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