Gliadin(GD) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Gliadin(GD) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Gliadin(GD)

OVA-Gliadin(GD)

Anti-Gliadin(GD) mouse monoclonal antibody

Anti-Gliadin(GD) human monoclonal antibody

Reference

Validation Data

Click to get more Data / Case study about the product.

Biomarker Information

1. Gliadin (GD) and Its Role in Allergens

Gliadin (GD) is a protein component found predominantly in gluten, a complex mixture of proteins present in various cereal grains, most notably wheat. It represents one of the major allergenic proteins inherent to gluten-containing grains, and its significance lies in its role as a primary trigger for immune responses associated with gluten-related disorders.

1.1 Structure and Characteristics of Gliadin

Gliadin is a heterogeneous protein, and it can be categorized into different fractions based on its solubility properties, including alpha, beta, gamma, and omega gliadins. These various forms of gliadin contribute to the distinctive viscoelastic properties of gluten, making it an essential component in the production of bread and other baked goods.

1.2 Gliadin and Gluten-Related Disorders

The role of gliadin in the context of allergens primarily revolves around its involvement in gluten-related disorders, including celiac disease and non-celiac gluten sensitivity. These conditions are characterized by adverse reactions to the ingestion of gluten-containing foods, with gliadin serving as a primary culprit.

1.2.1 Celiac Disease: In celiac disease, gliadin triggers an autoimmune response in genetically predisposed individuals. When individuals with celiac disease consume gluten-containing foods, such as wheat-based products, the immune system recognizes gliadin as a threat. This recognition leads to the production of antibodies, particularly tissue transglutaminase antibodies and anti-gliadin antibodies (IgA and IgG). These antibodies target and damage the lining of the small intestine, causing a range of gastrointestinal symptoms and potential long-term complications if left untreated.

1.2.2 Non-Celiac Gluten Sensitivity (NCGS): NCGS is a condition characterized by symptoms similar to celiac disease but without the autoimmune component and the intestinal damage seen in celiac disease. Gliadin is believed to be a key trigger for the symptoms experienced by individuals with NCGS. While the exact mechanisms behind NCGS are not fully understood, the role of gliadin in eliciting these symptoms is well-established.

2. Why Measure Gliadin (GD)?

Gliadin measurement plays a pivotal role in various aspects of managing and understanding gluten-related disorders and ensuring compliance with gluten-free dietary restrictions. Below, we delve into the multifaceted reasons for quantifying gliadin levels.

2.1 Diagnostic Utility

Gliadin measurement serves as a vital tool in the diagnostic process of gluten-related disorders. Accurate quantification of gliadin antibodies, particularly anti-gliadin antibodies (IgA and IgG), in a patient's blood can provide important diagnostic insights.

2.1.1 Celiac Disease Diagnosis: The detection of elevated levels of anti-gliadin antibodies, along with other diagnostic markers like tissue transglutaminase antibodies and endomysial antibodies, is a key step in confirming a diagnosis of celiac disease. These antibody tests help differentiate celiac disease from other gastrointestinal conditions and provide a basis for further diagnostic evaluation, such as endoscopy with biopsy.

2.1.2 Identifying Non-Celiac Gluten Sensitivity: While NCGS lacks the autoimmune component seen in celiac disease, it shares symptoms with the condition. Gliadin measurement can help rule out celiac disease in individuals with gluten sensitivity by confirming the absence of specific celiac-related antibodies, aiding in the differentiation of these two conditions.

2.2 Monitoring Dietary Adherence

For individuals diagnosed with celiac disease or NCGS, strict adherence to a gluten-free diet is imperative to prevent symptoms and complications. Regular measurement of gliadin levels can serve as a valuable tool to assess whether patients are effectively avoiding gluten-containing foods.

2.2.1 Assessing Gluten Ingestion: Gliadin measurement can detect even small amounts of inadvertent gluten ingestion. This is crucial because even trace amounts of gluten can trigger symptoms in individuals with gluten sensitivity or celiac disease. Monitoring gliadin levels allows healthcare providers to gauge the effectiveness of a patient's dietary choices.

2.2.2 Encouraging Compliance: Knowing that their gliadin levels are being monitored can motivate individuals to adhere more strictly to a gluten-free diet. It provides tangible feedback on the consequences of dietary lapses, emphasizing the importance of adherence.

2.3 Facilitating Food Labeling Compliance

The accurate quantification of gliadin is also of paramount importance in the food industry, where gluten-free labeling compliance is essential for consumer safety.

2.3.1 Quality Control: Food manufacturers must ensure that products labeled as gluten-free indeed contain negligible or no gluten. Gliadin testing methodologies play a critical role in quality control processes, verifying that gluten-free products meet regulatory standards.

2.3.2 Consumer Transparency: Accurate labeling allows consumers with gluten sensitivities or celiac disease to make informed choices about the foods they purchase. It fosters transparency in the food industry, instilling trust in gluten-free product claims.

2.4 Research and Therapeutic Advancements

In the realm of scientific research and pharmaceutical development, gliadin measurement assumes a pivotal role in several aspects.

2.4.1 Therapeutic Development: Researchers and pharmaceutical companies leverage gliadin measurements to develop therapies aimed at mitigating the effects of gluten-related disorders. Anti-gliadin antibodies and other potential treatments are subject to rigorous testing and validation, where accurate quantification of gliadin is essential.

2.4.2 Understanding Disease Mechanisms: Gliadin measurements contribute to a deeper understanding of the mechanisms underlying gluten-related disorders. Research endeavors elucidate the specific immune responses triggered by gliadin, aiding in the development of targeted therapies.

2.4.3 Epidemiological Studies: The measurement of gliadin levels in population-based studies can provide insights into the prevalence and incidence of gluten-related disorders. These studies are valuable for public health planning and resource allocation.

Conclusion

In conclusion, gliadin (GD) plays a central role in the allergenicity of gluten-containing grains, particularly in the context of gluten-related disorders such as celiac disease and non-celiac gluten sensitivity. The accurate quantification of gliadin antibodies and gliadin levels in various applications, including diagnostics, dietary management, food labeling compliance, and scientific research, is crucial for improving the lives of individuals with gluten sensitivities and advancing our understanding of these conditions. As a biopharmaceutical company specializing in anti-small molecules antibodies and small molecules competitive antigens, our role in providing accurate gliadin measurement tools is instrumental in supporting these endeavors.

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