Amlodipine(ADP) antibody and antigen (hapten, BSA/OVA conjugated)

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Diagnostic anti-Amlodipine (ADP) antibodies (anti-Amlodipine, anti-ADP) and diagnostic hapten-carrier conjugates BSA-Amlodipine (ADP), OVA-Amlodipine (ADP), KLH-Amlodipine (ADP) antigens for Cardiovascular disease ADP detection in ELISA test, competitive ELISA, Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Amlodipine(ADP)

OVA-Amlodipine(ADP)

Anti-human Amlodipine(ADP) mouse monoclonal antibody (mAb)

Anti-human Amlodipine(ADP) human monoclonal antibody (mAb)

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

1. Amlodipine: Comprehensive Pharmacological Profile and In Vitro Diagnostic Application

Amlodipine belongs to the dihydropyridine class of calcium channel blockers, distinguished by its efficacy in dilating peripheral arteries and reducing myocardial oxygen demand. This pharmacological action is mediated through the selective blockade of L-type calcium channels in the cardiovascular system, which inhibits calcium ions from entering vascular smooth muscle and cardiac cells. The result is a significant decrease in systemic vascular resistance and arterial blood pressure, with minimal effects on cardiac contractility and conduction. Amlodipine's pharmacokinetics are characterized by a long half-life, supporting once-daily dosing to achieve sustained blood pressure control and angina prevention.

In the realm of in vitro diagnostics (IVD), the precision measurement of Amlodipine levels in plasma or serum samples is facilitated through the development and utilization of advanced immunoassay techniques. These include the generation of high-affinity anti-Amlodipine antibodies and the synthesis of Amlodipine-derived competitive antigens, such as carrier-coupled antigens and hapten-carrier conjugates. The integration of these bioanalytical components into assays like ELISA, chemiluminescence, or mass spectrometry enhances the capability to monitor drug levels accurately, essential for therapeutic drug monitoring (TDM).

2. Imperative of Amlodipine Concentration Measurement in Clinical Settings

The quantitative measurement of Amlodipine serves multiple critical purposes in personalized patient care and medication management:

Optimization of Therapeutic Regimens: TDM of Amlodipine is imperative for calibrating doses to achieve optimal therapeutic blood levels, particularly in patients with hypertension and angina. This process is vital to ensure the medication's efficacy in lowering blood pressure and reducing the frequency of angina attacks, without surpassing the threshold that could lead to adverse effects such as peripheral edema, excessive hypotension, or reflex tachycardia.

Personalization of Medical Treatment: Given the wide interindividual variability in the pharmacokinetics and pharmacodynamics of Amlodipine, influenced by genetic factors, age, renal and hepatic function, and concurrent medication use, TDM is instrumental in tailoring treatment. This approach facilitates the adjustment of Amlodipine dosing to accommodate individual metabolic rates and drug interaction profiles, thereby personalizing therapy.

Management of Drug Interactions and Side Effects: Amlodipine's interaction with other drugs can either potentiate its hypotensive effect or alter its metabolism, necessitating careful monitoring of its levels in patients on multiple medications. Regular TDM helps in identifying and managing these interactions effectively, reducing the risk of adverse reactions.

Adherence Monitoring: Regularly measuring Amlodipine levels can also serve as an objective marker of patient adherence, a crucial component in managing chronic conditions like hypertension. Ensuring patients follow their prescribed regimen is key to achieving the desired therapeutic outcomes.

Research and Development: Beyond clinical applications, the measurement of Amlodipine levels supports pharmacokinetic and pharmacodynamic research, contributing to a better understanding of its action mechanisms, optimal dosing strategies, and potential new therapeutic indications.

In summary, the detailed measurement of Amlodipine through in vitro diagnostic methods is a cornerstone of modern therapeutic drug monitoring, ensuring that treatment is not only effective but also safe and personalized. This nuanced approach underscores the importance of sophisticated diagnostic tools in achieving the best possible patient outcomes in the management of hypertension and angina pectoris.

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