Biotin(BT) antibody and antigen (hapten, BSA/OVA conjugated)

Diagnostic anti-Biotin (BT) antibodies (anti-Biotin, anti-BT) and diagnostic hapten-carrier conjugates BSA-Biotin (BT), OVA-Biotin (BT), KLH-Biotin (BT) antigens for Metabolic diseases BT detection in ELISA test, competitive ELISA, Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

Target products collectionGo to Metabolic diseases diagnostics products collection>>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-SMT-219-Ag01BSA-Biotin(BT)$756.00
GMP-SMT-219-Ag02OVA-Biotin(BT)$756.00
GMP-SMT-219-Ab01Anti-human Biotin(BT) mouse monoclonal antibody (mAb)$1953.00
GMP-SMT-219-Ab02Anti-human Biotin(BT) human monoclonal antibody (mAb)$1953.00

Size: 1mg | 10mg | 100mg



Product Description

BSA-Biotin(BT)

Cat No.GMP-SMT-219-Ag01
Product NameBSA-Biotin(BT)
TargetBiotin(BT)
Expression platformSynthetic
Bioactivity validationBiotin(BT) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in BT level test of Metabolic diseases (Biotin deficiency) and related syndrome evaluation
Products descriptionCompetitive immunoassay-validated hapten-carrier conjugates BSA-Biotin(BT) / OVA-Biotin(BT) is Synthetic.
PurityHigh (TBD)
ApplicationCompetitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

OVA-Biotin(BT)

Cat No.GMP-SMT-219-Ag02
Product NameOVA-Biotin(BT)
TargetBiotin(BT)
Expression platformSynthetic
Bioactivity validationBiotin(BT) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in BT level test of Metabolic diseases (Biotin deficiency) and related syndrome evaluation
Products descriptionCompetitive immunoassay-validated hapten-carrier conjugates BSA-Biotin(BT) / OVA-Biotin(BT) is Synthetic.
PurityHigh (TBD)
ApplicationCompetitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-human Biotin(BT) mouse monoclonal antibody (mAb)

Cat No.GMP-SMT-219-Ab01
Product NameAnti-human Biotin(BT) mouse monoclonal antibody (mAb)
TargetBiotin(BT)
Expression platformhybridoma
IsotypesMouse IgG
Bioactivity validationBiotin(BT) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Biotin(BT) antibodies in BT level test of Metabolic diseases (Biotin deficiency) and related syndrome evaluation.
TagmFc
Products descriptionAnti-human Biotin(BT) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by hybridoma technology.
PurityHigh (TBD)
ApplicationCompetitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-human Biotin(BT) human monoclonal antibody (mAb)

Cat No.GMP-SMT-219-Ab02
Product NameAnti-human Biotin(BT) human monoclonal antibody (mAb)
TargetBiotin(BT)
Expression platformhybridoma
IsotypesHuman IgG1
Bioactivity validationBiotin(BT) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Biotin(BT) antibodies in BT level test of Metabolic diseases (Biotin deficiency) and related syndrome evaluation.
TaghFc
Products descriptionAnti-human Biotin(BT) mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCompetitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Data / case study


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    Target/Biomarker information


    Biotin in In Vitro Diagnosis (IVD): Biotin, also scientifically referred to as Vitamin B7 or Vitamin H, emerges as a paramount constituent within the intricate framework of in vitro diagnosis (IVD). Its role within this domain is multifaceted, manifesting as a cornerstone in numerous assay systems and diagnostic methodologies. Biotin's intrinsic significance primarily emanates from its capacity to serve as a conjugate or label in immunoassays and other sophisticated detection mechanisms harnessed extensively in IVD.

    In the specific context of IVD, Biotin finds profound utility as a conjugate. It becomes covalently linked to carrier proteins, such as Bovine Serum Albumin (BSA) or Ovalbumin (OVA), resulting in the formation of Biotinylated antigens. These Biotinylated antigens then embark on a pivotal journey as they are deployed to ascertain the presence or quantify the concentration of particular antibodies or analytes within patient specimens. A remarkable facet of Biotin lies in its exceptional binding affinity, particularly with Avidin or Streptavidin proteins, which renders it indispensable in assays of paramount importance. Assay methodologies such as enzyme-linked immunosorbent assays (ELISAs) and chemiluminescent immunoassays (CLIAs) stand as exemplars, where Biotinylated reagents underpin precision, sensitivity, and ultimately, the accuracy of diagnostic detection.

    Significance of Biotin Measurement in IVD:

    a. Quality Assurance (QA) and Control (QC): The meticulous measurement of Biotin holds a pivotal role in ensuring the veracity of in vitro diagnostic assays. This veracity hinges upon the quality and consistency of Biotinylated reagents, encompassing Biotin-conjugated antigens and antibodies. Rigorous measurement, therefore, assumes an indispensable role in quality assurance (QA) and control (QC) protocols, bolstering the generation of dependable assay outcomes. As Biotin is an elemental component of these reagents, precise measurement becomes pivotal to ascertain the optimal concentration and functionality of these diagnostic entities.

    b. Augmented Assay Sensitivity and Specificity: Within the intricate tapestry of in vitro diagnostic assays, the precise measurement of Biotin levels stands as a linchpin in optimizing assay parameters. Fine-tuning the concentration of Biotinylated reagents within assays is an imperative step in achieving heightened sensitivity and specificity. By deciphering the precise Biotin levels required, diagnostic tests become adept at discriminating minute variations in analyte concentrations, thereby augmenting their clinical utility and diagnostic accuracy.

    c. Mitigating Biotin Interference: Biotin interference represents a substantial concern in specific clinical assays. Elevated Biotin levels within patient specimens can potentially induce spurious results, leading to erroneous clinical interpretations. Precise measurement of Biotin levels within patient samples facilitates the identification of potential interference instances, empowering laboratory professionals to implement necessary protocol adjustments and ensure the reliability of assay results.

    d. Patient Biotin Level Monitoring: In selected clinical scenarios, the monitoring of Biotin levels within patients' biological matrices assumes clinical relevance. Excessive Biotin supplementation, either through dietary sources or supplements, can exert significant interference with laboratory test results. This interference is particularly pertinent in hormone assays. Comprehensive knowledge of a patient's Biotin levels enables healthcare practitioners to judiciously interpret test outcomes, ensuring that diagnostic conclusions are founded on accurate and unbiased data.

    In summation, the meticulous measurement of Biotin is an elemental and non-negotiable facet of in vitro diagnosis (IVD), pivotal for safeguarding the precision, sensitivity, and reliability of diagnostic assays reliant on Biotinylated reagents. It constitutes an indispensable element within the ambit of IVD, underpinning the scientific and clinical rigor of modern diagnostic practices. The careful consideration and precise measurement of Biotin levels serve as the bedrock upon which accurate clinical diagnoses are made, thereby shaping the landscape of healthcare and patient management.



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