Benzoditezite (BZO) antibody and antigen (hapten, BSA/OVA conjugated)

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Diagnostic anti-Benzoditezite (BZO) antibodies (anti-Benzoditezite, anti-BZO) and diagnostic hapten-carrier conjugates BSA-Benzoditezite (BZO), OVA-Benzoditezite (BZO), KLH-Benzoditezite (BZO) antigens for Multiple disease BZO detection in ELISA test, competitive ELISA, Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Benzoditezite (BZO)

OVA-Benzoditezite (BZO)

Anti-human Benzoditezite (BZO) mouse monoclonal antibody (mAb)

Anti-human Benzoditezite (BZO) human monoclonal antibody (mAb)

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Benzodiazepines, a class of psychoactive drugs, are central to managing a broad spectrum of CNS disorders due to their potent anxiolytic, sedative, muscle relaxant, and anticonvulsant effects. These drugs operate by potentiating the action of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, leading to enhanced inhibitory neurotransmission within the brain. While benzodiazepines are effective therapeutic agents, their potential for dependence, tolerance, and withdrawal necessitates careful monitoring. The pivotal role of in vitro diagnostics (IVD) in the detection and quantification of benzodiazepines in biological specimens is underscored by the necessity to balance therapeutic efficacy against the risk of adverse outcomes.

### 1. Benzodiazepines in Clinical and Forensic Settings

In clinical settings, the measurement of benzodiazepine concentrations via IVD assays is crucial for therapeutic drug monitoring (TDM). This process ensures drug levels remain within the therapeutic index, optimizing treatment outcomes for disorders such as anxiety, insomnia, and epilepsy while minimizing side effects. Additionally, in cases of suspected overdose, rapid and accurate benzodiazepine quantification can guide the administration of appropriate interventions, potentially saving lives.

Moreover, the significance of benzodiazepine measurement extends into forensic toxicology, where it aids in investigating cases of drug misuse, accidental or intentional overdose, and in scenarios involving drug-facilitated crimes. The ability to precisely detect and quantify benzodiazepines supports legal and compliance efforts, particularly in employment and sports settings, where drug-free policies are enforced.

### 2. Advanced Diagnostic Technologies for Benzodiazepine Detection

The development and application of highly specific anti-benzodiazepine antibodies and competitive antigens have revolutionized the field of IVD, enabling the creation of sensitive and specific assays. Techniques such as enzyme-linked immunosorbent assays (ELISA), chemiluminescent immunoassays (CLIA), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are employed to measure benzodiazepine levels with precision. These methodologies cater to diverse requirements, from rapid point-of-care testing (POCT) to comprehensive laboratory-based analyses, facilitating timely and informed clinical decision-making.

### 3. Implications of Benzodiazepine Measurement

The quantification of benzodiazepines has profound implications across various domains:

- **Therapeutic Drug Monitoring (TDM):** TDM is vital for personalizing benzodiazepine therapy, ensuring that patients receive dosages that maximize efficacy and minimize the risk of adverse effects or development of dependency. This approach is particularly relevant for long-term treatments and in populations with increased susceptibility to side effects, such as the elderly.

- **Emergency Medicine:** In acute care settings, identifying benzodiazepine intoxication enables clinicians to administer specific countermeasures, such as flumazenil, a benzodiazepine antagonist, thereby mitigating the risks associated with overdose.

- **Drug Abuse and Compliance:** Regular monitoring of benzodiazepine levels helps identify patterns of misuse or diversion, facilitating interventions aimed at preventing abuse. Additionally, it ensures that patients adhere to prescribed treatment regimens, crucial for the successful management of underlying conditions.

- **Forensic and Legal Applications:** Accurate benzodiazepine detection is essential in forensic investigations, contributing to the resolution of legal cases involving drug-facilitated assaults, DUI charges, and workplace drug testing disputes.

In summary, the measurement of benzodiazepines through advanced IVD technologies plays a critical role in optimizing patient care, safeguarding public health, and supporting forensic and legal processes. The ongoing development of innovative diagnostic reagents and methodologies promises to enhance the precision, efficiency, and utility of benzodiazepine detection in various settings, underscoring the intersection of pharmacology, medicine, and technology in contemporary healthcare and legal systems.

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