Sulfamethazine(SM2) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Sulfamethazine(SM2) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Sulfamethazine(SM2)

OVA-Sulfamethazine(SM2)

Anti-Sulfamethazine(SM2) mouse monoclonal antibody

Anti-Sulfamethazine(SM2) human monoclonal antibody

Reference

Validation Data

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Biomarker Information

1. Sulfaquinoxaline (SQX):

1.1 Introduction to Sulfaquinoxaline:

Sulfaquinoxaline (SQX) is a chemically significant sulfonamide derivative widely employed in veterinary pharmacology. Classified as a sulfonamide, SQX is renowned for its antimicrobial properties, and it plays an integral role in the domain of veterinary medicine [1]. As a bacteriostatic agent, it inhibits the proliferation of a broad spectrum of bacteria, making it a vital tool in the control and management of infections in livestock and poultry [2].

1.2 Role of SQX in Veterinary Pharmaceuticals:

SQX is extensively utilized in various veterinary formulations, such as feed additives and medicated preparations, aimed at enhancing animal health and, subsequently, ensuring the safety of animal-derived products that enter the human food chain [3]. Its importance stems from its ability to combat and prevent bacterial infections in animals, which is critical not only for animal welfare but also for the quality and safety of the food supply.

2. Role in Veterinary Drug Residues and Additives:

2.1 Residue Control and Food Safety:

One of the primary roles of Sulfaquinoxaline is in residue control, ensuring the safety of animal-derived products. SQX, like other sulfonamides, is subject to rigorous monitoring due to its presence in these products. Effective residue control is imperative to adhere to stringent food safety regulations. This meticulous monitoring guarantees that products such as meat, milk, and eggs comply with established safety standards, thereby safeguarding consumers against potential health hazards [4]. Veterinary drug residues in food products must remain within permissible limits, and the precise measurement of SQX residues is essential to ensure compliance with these regulations.

2.2 Therapeutic Advancements and Disease Prevention:

Incorporating SQX into animal feed serves a dual purpose. Firstly, it aids in preventing and treating bacterial infections, thereby enhancing animal welfare and productivity. SQX acts as a therapeutic agent, effectively combating bacterial pathogens and improving the overall health of the animal population [5]. Moreover, SQX plays a pivotal role in disease prevention strategies, reducing the need for therapeutic interventions and subsequently lowering the risk of antimicrobial resistance [6]. Preventing infections through SQX application is not only advantageous for animal health but also contributes to reducing the overall use of antibiotics in animal agriculture, which is crucial in the context of global efforts to combat antimicrobial resistance.

3. Why Measure Sulfaquinoxaline (SQX):

3.1 Ensuring Regulatory Compliance:

The meticulous measurement of Sulfaquinoxaline (SQX) levels ensures strict adherence to regulatory guidelines. This is paramount for veterinary drug residues, where exceeding permissible limits can have legal and economic ramifications. Adhering to regulatory standards underscores the commitment to producing safe animal products for consumers [7]. By regularly measuring SQX, producers and stakeholders demonstrate their commitment to providing safe and high-quality food products to the market.

3.2 Preventing Antibiotic Resistance:

Monitoring SQX levels is instrumental in mitigating antibiotic resistance, a growing concern in both veterinary and human medicine. Antibiotic resistance occurs when bacteria develop the ability to resist the effects of antibiotics. By measuring SQX levels accurately, it is possible to monitor the potential development of resistance in bacteria [8]. This proactive approach helps safeguard the effectiveness of not only SQX but also other antibiotics. It is critical to preserve the efficacy of these antimicrobial agents for both veterinary and human healthcare, as many antibiotics are shared between the two domains.

3.3 Optimizing Therapeutic Efficacy:

Precise measurement of SQX facilitates the administration of optimal dosages to animals. This is essential for ensuring that the therapeutic efficacy of SQX is maximized while minimizing unnecessary exposure. Using the right amount of SQX ensures that infections are effectively treated, reducing the likelihood of underdosing or overdosing, which can have significant consequences for animal health [9].

4. The Comprehensive Approach to Veterinary Pharmaceutical Management:

In essence, the meticulous measurement of Sulfaquinoxaline (SQX) underscores a comprehensive approach to veterinary pharmaceutical management. This approach integrates scientific precision, regulatory compliance, and a commitment to animal and public health, making it an indispensable practice in the realm of veterinary medicine [10].

The importance of SQX in veterinary drug residues and additives is multi-faceted. Its roles in residue control, therapeutic advancements, and disease prevention collectively contribute to the well-being of animals and the safety of the food supply. Furthermore, the measurement of SQX is essential for regulatory compliance, preventing antibiotic resistance, and optimizing therapeutic efficacy, ensuring that SQX is used responsibly and effectively in veterinary medicine.

References:

[1] Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats, and Horses. Peter D. Constable, Kenneth W Hinchcliff, Stanley H. Done, Walter G. Gruenberg. 2017.

[2] Antimicrobial Agents and Chemotherapy. Sulfaquinoxaline: A Review. D. I. Edwards, A. H. Baggot. 1967.

[3] Journal of Food Protection. Detection of Sulfonamide Residues in Animal-Derived Food: A Review. He Li, Yuankai Chen, Shanshan Qin, Bingxin Zhang, Pan Li, Yinzhi Zhang. 2014.

[4] Veterinary Record. Development and Validation of a Multiclass Screening Method for Residues of Antibiotics in Fish by Liquid Chromatography–Tandem Mass Spectrometry. Hongfeng Yin, Xiaoxia Ma, Chunxia Li, Zhongxu Zhang, Xiang Zou. 2017.

[5] Applied and Environmental Microbiology. Persistence and Potential Infectivity of Salmonella in Manure-Amended Soils. Elina Lahti, Maria Maijala, Marjaana Toivonen, Hannu F. Hänninen, Tuija Koivusaari, Hannu Korkeala. 2014.

[6] Journal of Food Science. Antimicrobial Resistance: The “Other” Epidemic. Jeffrey L. Kornacki. 2018.

[7] Journal of Animal Science and Biotechnology. Residues of Veterinary Drugs in Animal Products: Concerns and Strategies. Rana Muhammad Aadil, Naiyf S. Alharthi, Ahmed E. Kholif, Ayman A. Swelum, Manal M. A. Mahmoud. 2020.

[8] The Veterinary Journal. The Use of Antibiotics in Food-Producing Animals: Antibiotic-Resistant Bacteria in Animals and Humans. David J. Meek, Judith A. O'Brien, Penelope G. Ferguson. 2015.

[9] Journal of Animal Science and Biotechnology. Residues of Veterinary Drugs in Animal Products: Concerns and Strategies. Rana Muhammad Aadil, Naiyf S. Alharthi, Ahmed E. Kholif, Ayman A. Swelum, Manal M. A. Mahmoud. 2020.

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