Penicillin G antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Penicillin G antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-SMT-63-1	1. BSA-Penicillin G 2. Anti-Penicillin G mouse monoclonal antibody	$2709.00
GMP-SMT-63-2	1. OVA-Penicillin G 2. Anti-Penicillin G mouse monoclonal antibody	$2709.00
GMP-SMT-63-3	1. BSA-Penicillin G 2. Anti-Penicillin G human monoclonal antibody	$2709.00
GMP-SMT-63-4	1. OVA-Penicillin G 2. Anti-Penicillin G human monoclonal antibody	$2709.00
GMP-SMT-62-5	1. BSA-Penicillin G 2. Recombinant beta-lactams sensor protein	$2709.00
GMP-SMT-62-6	1. OVA-Penicillin G 2. Recombinant beta-lactams sensor protein	$2709.00
GMP-SMT-63-Ag-1	BSA-Penicillin G	$756.00
GMP-SMT-63-Ag-2	OVA-Penicillin G	$756.00
GMP-SMT-63-Ab-1	Anti-Penicillin G mouse monoclonal antibody	$1953.00
GMP-SMT-63-Ab-2	Anti-Penicillin G human monoclonal antibody	$1953.00
GMP-SMT-sensor-1	Recombinant beta-lactams sensor protein	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

BSA-Penicillin G

Cat No.	GMP-SMT-63-Ag-1
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Penicillin G with anti-Hapten antibody. The hapten hapten-carrier conjugates BSA-Penicillin G had been validated with our anti-Hapten antibody Anti-Penicillin G mouse monoclonal antibody via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

OVA-Penicillin G

Cat No.	GMP-SMT-63-Ag-2
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description	Competitive immunoassay-validated hapten-carrier conjugates OVA-Penicillin G with anti-Hapten antibody. The hapten hapten-carrier conjugates OVA-Penicillin G had been validated with our anti-Hapten antibody Anti-Penicillin G mouse monoclonal antibody via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Penicillin G mouse monoclonal antibody

Cat No.	GMP-SMT-63-Ab-1
Host of Antibody	Mouse IgG
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb)	0.1-0.2
Products description	The anti-Hapten antibody against hapten Penicillin G had been validated with our hapten hapten-carrier conjugates BSA-Penicillin G via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Penicillin G human monoclonal antibody

Cat No.	GMP-SMT-63-Ab-2
Host of Antibody	Human IgG1
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb)	0.1-0.2
Products description	The anti-Hapten antibody against hapten Penicillin G had been validated with our hapten hapten-carrier conjugates BSA-Penicillin G via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Recombinant beta-lactams sensor protein

Cat No.	GMP-SMT-Sensor-1
Antigen & Antibody Name	Recombinant beta-lactams sensor protein
Expression platform	mammalian cell
Isotypes	Recombinant protein
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
Tag	mFc
Products description	Recombinant beta-lactams sensor protein was expressed in mammalian cell expression system with mFc tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Antibody in Elisa, Competitive ELISA, lateral-flow tests, and other immunoassays
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Application development scientists of GDU (GeneMedi Diagnostics Unit) have generated and optimized the beta-lactams sensor protein with a larger linear range and better sensitivity against the beta-lactams. We tested 24 kinds of beta-lactams. Below is the competitive ELISA data of GeneMedi’s optimized beta-lactams sensor recombinant protein. For Ampicillin EC50 = 0.53 ng/ml (ppb); For Penicillin G, EC50 = 0.19 ng/ml (ppb). Our Recombinant beta-lactams sensor protein has obtained good performances, such as the stability and sensitivity.


Figure 1. GeneMedi's Recombinant beta-lactams sensor protein was validated to detect the beta-lactams (Ampicillin, Penicillin G, Cequinome, Cefapirin, Cephalexin, Ceftiofur) in ELISA.

Beta-lactams	Cross-Reactivity	Beta-lactams	Cross-Reactivity
Penicillin G	Y	Nafcillin	Y
Ampicillin	Y	Cephalothin	Y
Ceftiofur	Y	Cefapirin	Y
Cefquinome	Y	Cefoperazone	Y
Cephalosporin	Y	Cefotaxime	Y
Cephalexin	Y	Cefalotin	Y
Benzylpenicillin	Y	Cefuroxime	Y
Penicillin V	Y	Cefaclor	Y
Amoxicillin	Y	Ceftriaxone	Y
Oxacillin	Y	Cefamandole	Y
Cloxacillin	Y	Moxalactam	Y
Dicloxacillin	Y	Meropenem	Y
Kanamycin (Negative Control)	N	Tetracycline (Negative Control)	N

Table1. GeneMedi's Recombinant beta-lactams sensor protein can detect 24 kinds of beta-lactams with high sensitivity.

Click to get more Data / Case study about the product.

Biomarker Information

1. Penicillin G in Veterinary Drug Residues and Additives:

Penicillin G, an iconic antibiotic, occupies a central role within the realm of biopharmaceuticals, particularly in veterinary medicine [^1^]. This penicillin derivative, which has found applications in both human and veterinary healthcare, is a potent tool in combating bacterial infections. In the context of veterinary drug residues and additives, Penicillin G's significance becomes manifest [^1^].

1.1 Penicillin G Use in Veterinary Medicine:

Penicillin G is employed extensively in veterinary medicine to treat bacterial infections in animals. Its broad-spectrum antibacterial properties make it an invaluable asset for maintaining animal health and ensuring their well-being [^1^]. It is administered to a wide range of animals, from livestock to pets, when they succumb to bacterial diseases. The controlled use of Penicillin G has had a profound impact on animal husbandry, enhancing animal welfare and contributing to the production of safe and healthy animal-derived products, such as meat and milk [^1^].

1.2 The Challenge of Residues in Animal-Derived Products:

However, the administration of Penicillin G to animals brings forth an intricate challenge - the presence of antibiotic residues in animal-derived products. When animals are treated with Penicillin G, traces of the antibiotic can persist in their tissues, and consequently, in the products derived from them, including meat, milk, and eggs. These residues can potentially have far-reaching consequences, warranting meticulous attention and control [^1^].

1.3 Regulatory Oversight in Veterinary Drug Residues:

Regulatory bodies worldwide have established Maximum Residue Limits (MRLs) for various antibiotics, including Penicillin G, in animal-derived products. These limits are designed to ensure that the concentration of antibiotic residues in food products does not exceed levels that could pose a risk to human health [^1^]. Adherence to these regulatory standards is obligatory for all stakeholders in the food supply chain, from farmers to processors and distributors [^1^].

1.4 The Importance of Measuring Penicillin G Residues:

The need to measure Penicillin G residues is multifaceted, and it stems from a confluence of scientific, regulatory, and health-related factors:

1.4.1 Food Safety Assurance: The primary purpose of measuring Penicillin G residues in animal-derived products is to uphold the safety of the food supply. Rigorous monitoring is imperative to prevent inadvertent consumer exposure to elevated antibiotic concentrations, thus mitigating associated health risks [^1^]. High levels of antibiotic residues in consumables can lead to various health concerns, including allergic reactions and the development of antibiotic resistance.

1.4.2 Regulatory Adherence: Compliance with established MRLs is a critical aspect of food safety and regulatory conformance. Adhering to these standards is obligatory and non-compliance may entail legal repercussions and reputational risks [^1^]. Companies in the agricultural and food industries must ensure that their products meet these regulatory requirements to avoid legal consequences and maintain their standing in the market.

1.4.3 Antibiotic Resistance Mitigation: The overuse of antibiotics, including Penicillin G, in veterinary medicine can contribute to the development of antibiotic-resistant bacteria. Antibiotic resistance is a significant global public health concern, as it limits the effectiveness of these crucial drugs in treating infections [^1^]. By measuring and controlling Penicillin G levels in animal-derived products, we can contribute to the responsible use of antibiotics, thereby minimizing the risk of antibiotic resistance development.

1.4.4 Consumer Confidence Upheld: In an era of heightened consumer consciousness about the safety and quality of the food they consume, regular monitoring of Penicillin G residues becomes essential. Consumers expect their food to be free from harmful antibiotic residues, and they often look for assurances of this in product labeling and marketing [^1^]. Providing such assurances can enhance consumer confidence in your products and brand, which is crucial for maintaining market share and a positive reputation.

2. Significance of Penicillin G Measurement:

a. Food Safety Assurance: The meticulous measurement of Penicillin G levels in animal-derived products is imperative for upholding the safety of the food supply chain. Rigorous monitoring is crucial to prevent unwarranted consumer exposure to elevated antibiotic concentrations, mitigating associated health risks. High levels of antibiotic residues can lead to various health concerns, including allergic reactions and the development of antibiotic resistance [^2^].

b. Regulatory Adherence: Compliance with established Maximum Residue Limits (MRLs) is imperative for regulatory conformance. Adhering to stipulated standards is obligatory, and non-compliance may entail legal repercussions and reputational risks. Companies in the agricultural and food industries must ensure that their products meet these regulatory requirements to avoid legal consequences and maintain their standing in the market [^2^].

c. Antibiotic Resistance Mitigation: The quantification of Penicillin G aligns with the judicious use of antibiotics, curbing the escalation of antibiotic resistance. This facet underscores the pivotal role played by measurement practices in averting broader public health challenges. Antibiotic resistance is a growing concern globally, and prudent antibiotic usage is essential in mitigating its impact [^2^].

d. Consumer Confidence Upheld: In an era of heightened consumer consciousness, regular monitoring of Penicillin G resonates with consumer expectations of food safety. This engenders confidence by affirming the absence of deleterious antibiotic residues. Consumers are increasingly looking for transparency in food labeling and assurance that their food is free from harmful contaminants, such as antibiotic residues [^2^].

In conclusion, the meticulous measurement of Penicillin G epitomizes a scientific imperative, addressing food safety, regulatory adherence, antibiotic resistance mitigation, and consumer confidence, thereby underscoring the indispensability of your biopharmaceutical offerings in advancing such analytical methodologies [^1^][^2^]. By providing innovative solutions in the form of anti-small molecules antibodies and small molecules competitive antigens, your company is well-positioned to contribute significantly to the scientific advancements required to meet these critical industry needs.

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