Canine Adenovirus hexon protein antibody and antigen (recombinant protein)

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Diagnostic anti-Canine Adenovirus hexon protein antibodies pairs and antigen for animal health (animal Dog/Canine infectious disease Hepatitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P013-Tg001-Ag01	Recombinant Canine Adenovirus hexon protein protein	$3090.00
GMP-VT-P013-Tg001-Ab01	Anti-Canine Adenovirus hexon protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P013-Tg001-Ab02	Anti-Canine Adenovirus hexon protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P013-Tg001-Ab03	Anti-Canine Adenovirus hexon protein human monoclonal antibody (mAb)	$3090.00
GMP-VT-P013-Tg001-Ab04	Anti-Canine Adenovirus hexon protein human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P013-Tg001-Ag01
Product Name	Recombinant Canine Adenovirus hexon protein protein
Pathogen	Canine Adenovirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Adenovirus hexon protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine Adenovirus level test of animal Dog/Canine infectious disease with Hepatitis.
Tag	His
Product description	Recombinant Canine Adenovirus hexon protein proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P013-Tg001-Ab01,GMP-VT-P013-Tg001-Ab02
Pathogen	Canine Adenovirus
Product Name	Anti-Canine Adenovirus hexon protein mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Adenovirus hexon protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Adenovirus antibodies in Canine Adenovirus level test of animal Dog/Canine infectious disease with Hepatitis.
Product description	Anti-Canine Adenovirus hexon protein mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Adenovirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P013-Tg001-Ab03,GMP-VT-P013-Tg001-Ab04
Pathogen	Canine Adenovirus
Product Name	Anti-Canine Adenovirus hexon protein human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Canine Adenovirus hexon protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Adenovirus antibodies in Canine Adenovirus level test of animal Dog/Canine infectious disease with Hepatitis.
Product description	Anti-Canine Adenovirus hexon protein mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

1. Comprehensive Identification of the Pathogen:

Scientific Names: Within the broad realm of pathogens that afflict canines, two particularly distinct strains emerge: Canine Adenovirus Type 1 (CAV-1) and Canine Adenovirus Type 2 (CAV-2).

Description: As members of the Adenoviridae family, Canine Adenoviruses are recognized by their non-enveloped DNA constitution. These viruses demonstrate a remarkable specificity for canine hosts. Distinctively, CAV-1 is the causative agent behind infectious canine hepatitis, a liver-centric ailment, while CAV-2 is more frequently associated with diseases of the respiratory tract in canines.

2. Scientific Classification of the Pathogen:

Taxonomic Hierarchy: When classifying life forms, viruses represent a unique domain. Within this spectrum, the Canine Adenoviruses fall.

Family Distinction: Nestled within the Adenoviridae family, Canine Adenoviruses share traits with other adenoviruses but have a predilection for canine species, setting them apart.

3. Detailed Structure and Genomic Outline:

Genomic Constitution: Central to its identity is its double-stranded DNA genome. This linear molecule encodes the instructions for the virus's life cycle, from entry into the host cell to the production of progeny virions.

Prominent Genes and Proteins: Adenoviruses, including the canine variants, boast a series of genes that sequentially transcribe early (E) proteins and late (L) proteins. Early proteins play a role in the initial takeover of the host cellular machinery, facilitating viral replication. In contrast, late proteins, produced once replication is underway, are paramount for the assembly of new virions. The hexon and fiber proteins, in particular, are pivotal to the adenovirus's identity, not only providing structural integrity but also serving as key interaction points during host infection.

4. Host Affinity and Disease Manifestations:

Primary Hosts: Members of the Canidae family, especially domesticated dogs, stand as the primary targets. This host specificity underlines the virus's evolutionary journey, honed over millennia to adeptly infect canine species.

Associated Diseases:

CAV-1: Infectious Canine Hepatitis (ICH) emerges as a predominant concern. As the nomenclature suggests, this ailment is primarily hepatic but doesn't shy away from displaying systemic manifestations. Infected dogs might present with symptoms ranging from mild lethargy to severe liver dysfunction.

CAV-2: This strain plays a contributory role in the Canine Infectious Respiratory Disease Complex (CIRDC). In layman's terms, it's often labeled as "Kennel Cough." However, it's essential to note that this respiratory syndrome often involves co-infection with other pathogens, such as Bordetella bronchiseptica, which collectively produce the clinical picture.

5. Advanced Diagnostic Paradigms:

Polymerase Chain Reaction (PCR): A linchpin in contemporary molecular diagnostics, PCR techniques tailored for CAV detection zero in on specific fragments of the virus's genome. By amplifying these regions exponentially, even minuscule viral quantities become detectable.

Viral Isolation Techniques: Rooted in traditional virology, this approach entails extracting the virus from pertinent clinical samples—be it blood, feces, or tissue—and nurturing it in dedicated canine cell lines. Observing viral growth and consequent cellular changes gives a direct indication of the virus's presence.

Serology: Techniques like the Enzyme-linked Immunosorbent Assay (ELISA) operate on the principle of antibody detection. When a dog's immune system encounters CAV, it mounts a defensive response, producing antibodies. By gauging the concentration of these specific antibodies in serum, one can infer either a past infection or a vaccination event.

Diagnostic Molecular Targets: For diagnostic precision, tools often home in on the genes encoding the hexon and fiber proteins. Their prominence in the viral structure, coupled with their roles in the viral life cycle, make them ideal molecular beacons.

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