Borrelia bovis antibody and antigen (recombinant protein)

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Diagnostic anti-Borrelia bovis antibodies pairs and antigen for animal health (animal Bovines/Cattle infectious disease Borrelia theileri infection) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P040-Tg001-Ag01	Recombinant Borrelia bovis protein	$3090.00
GMP-VT-P040-Tg001-Ab01	Anti-Borrelia bovis mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P040-Tg001-Ab02	Anti-Borrelia bovis mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P040-Tg001-Ab03	Anti-Borrelia bovis human monoclonal antibody (mAb)	$3090.00
GMP-VT-P040-Tg001-Ab04	Anti-Borrelia bovis human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P040-Tg001-Ag01
Product Name	Recombinant Borrelia bovis protein
Pathogen	Borrelia bovis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Borrelia bovis antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Borrelia bovis level test of animal Bovines/Cattle infectious disease with Borrelia theileri infection.
Tag	His
Product description	Recombinant Borrelia bovis proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P040-Tg001-Ab01,GMP-VT-P040-Tg001-Ab02
Pathogen	Borrelia bovis
Product Name	Anti-Borrelia bovis mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Borrelia bovis antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Borrelia bovis antibodies in Borrelia bovis level test of animal Bovines/Cattle infectious disease with Borrelia theileri infection.
Product description	Anti-Borrelia bovis mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Borrelia bovis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P040-Tg001-Ab03,GMP-VT-P040-Tg001-Ab04
Pathogen	Borrelia bovis
Product Name	Anti-Borrelia bovis human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Borrelia bovis antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Borrelia bovis antibodies in Borrelia bovis level test of animal Bovines/Cattle infectious disease with Borrelia theileri infection.
Product description	Anti-Borrelia bovis mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Borrelia bovis: A Comprehensive Overview

Borrelia bovis is a bacterium of significant veterinary importance that belongs to the spirochete group, a distinctive class of bacteria characterized by its corkscrew or helical shape. As part of the Borrelia genus, Borrelia bovis plays a central role in the context of livestock health, particularly in cattle and other domesticated ruminants. This comprehensive overview delves into various facets of Borrelia bovis, including its classification, structural attributes, host specificity, diseases it causes, and the diagnostic methods utilized for its detection.

Classification and Morphology:

Borrelia bovis falls under the classification of prokaryotic bacteria. Within the domain of prokaryotes, it belongs to the phylum Spirochaetes, which is named after its characteristic spiral or helical shape. This unique morphology enables spirochetes, including Borrelia bovis, to exhibit exceptional motility, allowing them to navigate various biological environments with ease. The Gram-negative nature of this bacterium is another distinguishing feature, revealing its cell wall structure.

Structural Insights:

The genetic composition of Borrelia bovis encodes an array of genes that are pivotal for its pathogenicity and survival. Notable among these genes are those responsible for motility and chemotaxis, facilitating its movement within the host organism. Borrelia species are also renowned for their capacity for antigenic variation, a mechanism that aids in immune system evasion. On the protein level, Borrelia bovis displays outer surface proteins (Osps), which are central in interactions with the host immune system and adherence to host tissues. The outer membrane of these spirochetes is equipped with an array of lipoproteins, including Osps, contributing to their adaptability and virulence.

Host Specificity and Diseases:

Borrelia bovis exhibits a strong affinity for cattle and domesticated ruminants, although it has been documented in a few cases to infect other mammalian species as well. In its primary host, cattle, Borrelia bovis is responsible for causing Bovine Borreliosis, a disease with a diverse range of clinical manifestations. Affected cattle often display symptoms such as fever, lameness, joint inflammation, and, in some instances, reduced milk production. The severity of the disease can vary, with some animals experiencing more acute forms of infection than others.

Diagnostic Methods:

Accurate diagnosis is pivotal for timely and effective management of Borrelia bovis infections. Various scientific methods are employed for this purpose, each with its own set of advantages and applications. Notable diagnostic approaches include:

Serological Tests: Enzyme-linked immunosorbent assays (ELISA) and Western blot assays are widely used to detect specific antibodies generated in response to Borrelia bovis infection. These tests provide valuable insights into the presence of the pathogen in the host, relying on the detection of antibodies directed against Borrelia bovis antigens.

Molecular Methods: Nucleic acid-based techniques are considered the gold standard for diagnosing Borrelia bovis infections. Polymerase Chain Reaction (PCR) stands out as a highly specific and sensitive method for detecting the presence of Borrelia bovis DNA in various biological samples. By targeting specific genetic markers, PCR enables the precise identification and confirmation of infection.

Target Genes/Proteins: In the realm of molecular diagnostics, specific genes and proteins serve as the linchpin for detection. These may include genes encoding outer surface proteins (Osps), which are highly variable and exhibit significant immunogenicity. Additionally, unique Borrelia bovis-specific genes are of interest, as they can offer heightened specificity in identifying the pathogen.

In conclusion, Borrelia bovis, as a member of the Borrelia genus, is a prokaryotic bacterium with a distinct helical shape, exhibiting pathogenicity primarily in cattle and domesticated ruminants. Its ability to cause Bovine Borreliosis underscores its veterinary significance. Accurate diagnostic methods, encompassing serological and molecular techniques that target specific genes and proteins, are vital for timely detection and management of Borrelia bovis infections. Understanding the intricacies of this pathogen is essential for the welfare of livestock and the maintenance of animal health in agricultural settings.

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