Borna disease virus P40 antibody and antigen (recombinant protein)

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Diagnostic anti-Borna disease virus P40 antibodies pairs and antigen for animal health (animal Bovines/Cattle infectious disease Borna disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P076-Tg001-Ag01	Recombinant Borna disease virus P40 protein	$3090.00
GMP-VT-P076-Tg001-Ab01	Anti-Borna disease virus P40 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P076-Tg001-Ab02	Anti-Borna disease virus P40 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P076-Tg001-Ab03	Anti-Borna disease virus P40 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P076-Tg001-Ab04	Anti-Borna disease virus P40 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P076-Tg001-Ag01
Product Name	Recombinant Borna disease virus P40 protein
Pathogen	Borna disease virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Borna disease virus P40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Borna disease virus level test of animal Bovines/Cattle infectious disease with Borna disease.
Tag	His
Product description	Recombinant Borna disease virus P40 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P076-Tg001-Ab01,GMP-VT-P076-Tg001-Ab02
Pathogen	Borna disease virus
Product Name	Anti-Borna disease virus P40 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Borna disease virus P40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Borna disease virus antibodies in Borna disease virus level test of animal Bovines/Cattle infectious disease with Borna disease.
Product description	Anti-Borna disease virus P40 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Borna disease virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P076-Tg001-Ab03,GMP-VT-P076-Tg001-Ab04
Pathogen	Borna disease virus
Product Name	Anti-Borna disease virus P40 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Borna disease virus P40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Borna disease virus antibodies in Borna disease virus level test of animal Bovines/Cattle infectious disease with Borna disease.
Product description	Anti-Borna disease virus P40 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Borna disease virus (BDV) is a highly infectious monocarboxylic virus that primarily infects the central nervous system (CNS) of a wide range of vertebrate hosts. BDV belongs to the Bornaviridae family within the order Mononegavirales, and is classified as an Orthobornavirus genus. The virus has been isolated from a variety of hosts, including mammals, birds, reptiles, and fish.

The genome of BDV is a non-segmented, linear, single-stranded RNA molecule which encodes six major proteins, including the nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), polymerase protein (L), and X protein (X). The N protein is the most abundant protein and plays a critical role in binding to the viral genomic RNA, forming the ribonucleoprotein complex. The P protein mediates the interaction between the L protein and viral RNA, facilitating RNA replication. The G protein is associated with cell entry and membrane fusion, while the L protein is responsible for RNA-dependent RNA polymerase activity, which is essential for RNA synthesis.

BDV infection results in a variety of neurological disorders, including Borna disease (BD), which is characterized by progressive, non-suppurative encephalitis in horses and sheep, and severe meningoencephalitis in humans. In horses and sheep, BD is associated with behavioral changes and neurological symptoms, such as ataxia, head-pressing, and seizures. In humans, BDV infection is associated with a wide range of psychiatric and neurological symptoms, including depression, anxiety, aggression, and cognitive impairment. Additionally, BDV infection has been linked to several human diseases, such as multiple sclerosis, schizophrenia, and bipolar disorder.

There are various diagnostic methods for BDV infection, including serological and molecular methods. Serological methods, such as ELISA, IFA, and Western blotting, detect the presence of BDV-specific antibodies in serum or cerebrospinal fluid (CSF) samples. The diagnostic sensitivity and specificity of these methods depend on the quality of the antigen used as well as the selection of the appropriate sample type and time of collection. Molecular methods, such as RT-PCR and real-time RT-PCR, can detect BDV RNA in blood, CSF, or brain tissue samples. RT-PCR has been reported to be more sensitive than ELISA for detecting BDV RNA in human CSF samples and can assist in the early diagnosis of BDV infection.

In conclusion, BDV is a highly infectious virus that primarily infects the CNS of a wide range of vertebrate hosts. Infection with BDV can result in various neurological disorders, including BD in horses and sheep, and severe meningoencephalitis in humans. There are various diagnostic methods for BDV infection, including serological and molecular methods, which can help in the accurate diagnosis of BDV infection and assist in the development of effective preventive measures.

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