PseudoRabies Virus gIII antibody and antigen (recombinant protein)
Diagnostic anti-PseudoRabies Virus gIII antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease Pseudorabies) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-VT-P105-Tg002-Ag01 | Recombinant PseudoRabies Virus gIII protein | $3090.00 |
GMP-VT-P105-Tg002-Ab01 | Anti-PseudoRabies Virus gIII mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P105-Tg002-Ab02 | Anti-PseudoRabies Virus gIII mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P105-Tg002-Ab03 | Anti-PseudoRabies Virus gIII human monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P105-Tg002-Ab04 | Anti-PseudoRabies Virus gIII human monoclonal antibody (mAb) | $3090.00 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. | GMP-VT-P105-Tg002-Ag01 |
Product Name | Recombinant PseudoRabies Virus gIII protein |
Pathogen | PseudoRabies Virus |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Anti-PseudoRabies Virus gIII antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PseudoRabies Virus level test of animal Swine/Porcine/Pig infectious disease with Pseudorabies. |
Tag | His | Product description | Recombinant PseudoRabies Virus gIII proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P105-Tg002-Ab01,GMP-VT-P105-Tg002-Ab02 |
Pathogen | PseudoRabies Virus |
Product Name | Anti-PseudoRabies Virus gIII mouse monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Recombinant PseudoRabies Virus gIII antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PseudoRabies Virus antibodies in PseudoRabies Virus level test of animal Swine/Porcine/Pig infectious disease with Pseudorabies. |
Product description | Anti-PseudoRabies Virus gIII mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PseudoRabies Virus antibodies. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P105-Tg002-Ab03,GMP-VT-P105-Tg002-Ab04 |
Pathogen | PseudoRabies Virus |
Product Name | Anti-PseudoRabies Virus gIII human monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Human lgG1 |
Bioactivity validation | Recombinant PseudoRabies Virus gIII antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PseudoRabies Virus antibodies in PseudoRabies Virus level test of animal Swine/Porcine/Pig infectious disease with Pseudorabies. |
Product description | Anti-PseudoRabies Virus gIII mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
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Pathogen Information
Pseudorabies virus (PRV), also known as Aujeszky's disease virus or Porcine herpesvirus 1 (PHV-1), is a highly infectious agent that belongs to the Herpesviridae family. This virus is characterized by its double-stranded DNA genome and its neurotropic nature, meaning it specifically targets the nervous system of infected hosts. PRV is primarily a disease of pigs, but it can infect many other mammalian species, including cattle, sheep, goats, dogs, cats, and wild carnivores. Infected animals can present with various clinical symptoms.
The structure of PRV is complex, consisting of several structural proteins including glycoproteins gB, gC, gD, gH, and gL. These envelope proteins facilitate the attachment and entry of the virus into host cells. PRV is unique among herpesviruses in that it can spread via multiple routes, including direct contact between animals, aerosol transmission, ingestion of contaminated feed, and even via contaminated fomites such as clothing and equipment.
The UL44 gene of PRV encodes for the DNA polymerase processivity factor, which is essential for replication and propagation of the virus. The gE gene of PRV encodes for a virion envelope protein. The gE protein plays a key role in neuroinvasion and the establishment of latency in the nervous system. The gE protein can also inhibit the migration of dendritic cells to lymph nodes, which may contribute to immune evasion by the virus.
Pigs are the natural host of PRV, and the virus is endemic in many pig populations worldwide. In pigs, PRV infection results in Aujeszky's disease, which is characterized by fever, respiratory distress, and neurological symptoms such as convulsions, ataxia, and hyperthermia. In severe cases, mortality rates can be as high as 100%, particularly in young pigs. Although Aujeszky's disease is a significant concern for the swine industry, the virus can also be transmitted to other animals, including dogs and wild carnivores. In these animals, the virus may cause respiratory issues, fever, and even death.
Diagnosing PRV infection can be challenging because clinical signs may vary between species. However, there are a range of diagnostic methods available. Serological tests such as enzyme-linked immunosorbent assay (ELISA) and virus neutralization test can detect antibodies against PRV in blood samples. Nucleic acid-based techniques, including polymerase chain reaction (PCR) and reverse transcription-PCR (RT-PCR), can detect viral DNA in clinical samples such as nasal swabs, blood, and tissues. These PCR assays typically target specific genes, such as the gE gene, which is highly conserved among PRV strains. Immunohistochemistry can also be used to identify the presence of virus antigen in tissue samples.
Preventing and controlling PRV infection is critical for protecting animal health and the swine industry. Vaccination is an effective way to control PRV in pigs. Inactivated or live attenuated PRV vaccines are available and have been widely used in many countries. Proper biosecurity measures, including cleaning and disinfection of equipment and facilities, can also help reduce the risk of PRV transmission. Additionally, early detection and reporting of suspected cases to veterinary authorities can facilitate rapid control and prevention measures.
In conclusion, Pseudorabies virus is a complex and highly infectious agent that primarily affects pigs but can also impact many other mammalian species. Understanding the structure, replication, and transmission of this virus is essential for developing effective control strategies to minimize its impact on animal health and the swine industry.
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