Haemophilus parasuis TbpB antibody and antigen (recombinant protein)

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Diagnostic anti-Haemophilus parasuis TbpB antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease Glässers Disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P119-Tg001-Ag01	Recombinant Haemophilus parasuis TbpB protein	$3090.00
GMP-VT-P119-Tg001-Ab01	Anti-Haemophilus parasuis TbpB mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P119-Tg001-Ab02	Anti-Haemophilus parasuis TbpB mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P119-Tg001-Ab03	Anti-Haemophilus parasuis TbpB human monoclonal antibody (mAb)	$3090.00
GMP-VT-P119-Tg001-Ab04	Anti-Haemophilus parasuis TbpB human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P119-Tg001-Ag01
Product Name	Recombinant Haemophilus parasuis TbpB protein
Pathogen	Haemophilus parasuis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Haemophilus parasuis TbpB antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Haemophilus parasuis level test of animal Swine/Porcine/Pig infectious disease with Glässers Disease.
Tag	His
Product description	Recombinant Haemophilus parasuis TbpB proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P119-Tg001-Ab01,GMP-VT-P119-Tg001-Ab02
Pathogen	Haemophilus parasuis
Product Name	Anti-Haemophilus parasuis TbpB mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Haemophilus parasuis TbpB antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Haemophilus parasuis antibodies in Haemophilus parasuis level test of animal Swine/Porcine/Pig infectious disease with Glässers Disease.
Product description	Anti-Haemophilus parasuis TbpB mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Haemophilus parasuis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P119-Tg001-Ab03,GMP-VT-P119-Tg001-Ab04
Pathogen	Haemophilus parasuis
Product Name	Anti-Haemophilus parasuis TbpB human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Haemophilus parasuis TbpB antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Haemophilus parasuis antibodies in Haemophilus parasuis level test of animal Swine/Porcine/Pig infectious disease with Glässers Disease.
Product description	Anti-Haemophilus parasuis TbpB mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Haemophilus parasuis is a bacterial pathogen that can cause severe respiratory disease in pigs, known as porcine infectious pleuropneumonia (IPP). This disease can result in significant economic losses for pig farmers worldwide. Therefore, it is crucial to understand the characteristics of Haemophilus parasuis and effective methods of diagnosing and controlling this pathogen.

Haemophilus parasuis is a Gram-negative bacterium, primarily found in the upper respiratory tract of pigs. It is shaped like a bacillus and measures approximately 0.5-1.5 μm in length and 0.2-0.5 μm in width. It is a mesophilic organism with an optimal growth temperature range of 37-42°C and grows best under microaerophilic conditions. The genome of Haemophilus parasuis has been sequenced, revealing several virulence factors, such as LPS, CPS, and OMPs. These proteins contribute to the pathogenicity of Haemophilus parasuis and are involved in adhesion, invasion, and evasion of the host's immune system.

Haemophilus parasuis mainly infects pigs of all ages, causing a broad spectrum of clinical signs ranging from subclinical infection to fatal disease. IPP is a common manifestation of Haemophilus parasuis infection, with acute or chronic forms of the disease reported. The most common symptoms include fever, respiratory distress, cough, and nasal discharge, which can lead to death in severe cases. Other signs may include anorexia, lethargy, and depression. The clinical signs of Haemophilus parasuis infection are often difficult to differentiate from those caused by other swine respiratory pathogens, such as Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae.

Accurate diagnosis of Haemophilus parasuis infection is essential to ensure effective control and prevention of the disease. Traditional diagnostic methods include bacterial culture, serology, and histopathology. However, bacterial culture may not be a reliable method for diagnosing Haemophilus parasuis because the bacterium requires specialized growth conditions. Histopathology can confirm the presence of Haemophilus parasuis in sampled tissues but cannot distinguish between pathogenic and non-pathogenic strains. Serological testing can detect antibodies against Haemophilus parasuis in the blood of infected animals, but the test is not always reliable, as the immune response to the bacterium is not well understood.

PCR-based methods have been developed as an alternative to traditional diagnostic techniques for Haemophilus parasuis detection. PCR enables the rapid and sensitive identification of Haemophilus parasuis by targeting specific DNA sequences, such as 16S rRNA gene and virulence genes, including the htrA gene. This method has been shown to be more sensitive than bacterial culture for detecting Haemophilus parasuis and can be used to diagnose subclinical infections. ELISA-based methods have also been used for serological diagnosis, targeting CPS and OMPs.

Effective control of Haemophilus parasuis infections is necessary to prevent economic losses in pig farming. Vaccination and antimicrobial treatments are two common control methods employed to prevent and treat Haemophilus parasuis infection. Commercial vaccines containing inactivated or subunit antigens are available and have been proven effective in reducing the incidence and severity of Haemophilus parasuis-related diseases. Monitoring of antibiotic susceptibility patterns is crucial in selecting appropriate antimicrobial agents for treatment, and strict antibiotic stewardship practices must be adhered to prevent antimicrobial resistance. Moreover, good management practices, strict biosecurity measures, and adequate ventilation are critical in minimizing Haemophilus parasuis transmission and infection.

In conclusion, Haemophilus parasuis infection is a significant concern for pig farmers worldwide. The bacterium is a Gram-negative organism that primarily infects pigs and causes porcine infectious pleuropneumonia, which can result in severe economic losses. Accurate diagnosis and effective control of Haemophilus parasuis infections are critical in preventing and controlling the spread of this pathogen. The diagnostic methods include bacterial culture, PCR-based methods, and ELISA-based methods. Vaccination and antimicrobial treatments are common control approaches used in pig farming to prevent and treat Haemophilus parasuis infections.

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