Taylorella equigenitalis antibody and antigen (recombinant protein)

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Diagnostic anti-Taylorella equigenitalis antibodies pairs and antigen for animal health (animal Equine/Horse infectious disease contagious equine metritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P135-Tg001-Ag01	Recombinant Taylorella equigenitalis protein	$3090.00
GMP-VT-P135-Tg001-Ab01	Anti-Taylorella equigenitalis mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P135-Tg001-Ab02	Anti-Taylorella equigenitalis mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P135-Tg001-Ab03	Anti-Taylorella equigenitalis human monoclonal antibody (mAb)	$3090.00
GMP-VT-P135-Tg001-Ab04	Anti-Taylorella equigenitalis human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P135-Tg001-Ag01
Product Name	Recombinant Taylorella equigenitalis protein
Pathogen	Taylorella equigenitalis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Taylorella equigenitalis antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Taylorella equigenitalis level test of animal Equine/Horse infectious disease with contagious equine metritis.
Tag	His
Product description	Recombinant Taylorella equigenitalis proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P135-Tg001-Ab01,GMP-VT-P135-Tg001-Ab02
Pathogen	Taylorella equigenitalis
Product Name	Anti-Taylorella equigenitalis mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Taylorella equigenitalis antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Taylorella equigenitalis antibodies in Taylorella equigenitalis level test of animal Equine/Horse infectious disease with contagious equine metritis.
Product description	Anti-Taylorella equigenitalis mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Taylorella equigenitalis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P135-Tg001-Ab03,GMP-VT-P135-Tg001-Ab04
Pathogen	Taylorella equigenitalis
Product Name	Anti-Taylorella equigenitalis human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Taylorella equigenitalis antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Taylorella equigenitalis antibodies in Taylorella equigenitalis level test of animal Equine/Horse infectious disease with contagious equine metritis.
Product description	Anti-Taylorella equigenitalis mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Taylorella equigenitalis is a gram-negative bacterium that primarily infects horses and causes the contagious equine metritis (CEM) disease. It belongs to the β-Proteobacteria class, Burkholderiaceae family, and is a non-spore forming, rod-shaped bacteria.

The bacterium was first isolated and characterized in 1977 by Arthur J. Williams and his colleagues at the Animal Disease Research Unit in Pullman, Washington. Since then, a significant amount of research has been conducted to understand the pathogenesis of this organism.

Taylorella equigenitalis is a highly infectious bacterium and is mainly transmitted during the breeding of horses. The pathogen attaches itself to the genital tract of horses, indicating that the bacterium's adherence ability plays a vital role in its pathogenicity. Once the bacterium gains entry into the host's tissues, it can cause inflammation and disrupt the normal functioning of the reproductive system.

The genome of Taylorella equigenitalis encodes various virulence factors that contribute to its pathogenicity. These virulence factors include surface-exposed proteins, adhesins, flagella, and lipopolysaccharides. The genes responsible for these virulence factors have been identified, and their contribution to pathogenesis has been studied extensively.

One of the most prominent virulence factors is the LPS or endotoxin produced by the bacterium. LPS is a component of the bacterial outer membrane, and it is well-known for its ability to induce inflammation. The LPS of Taylorella equigenitalis has been shown to be highly immunogenic and can elicit an immune response in the host.

Another important virulence factor is the motility-related protein, which contributes to the bacterium's ability to move within the host tissues. The motility of Taylorella equigenitalis is mediated by its flagella, which are responsible for the bacterium's movement towards its target cells.

Iron acquisition is an essential virulence factor for many pathogens. Taylorella equigenitalis produces proteins that enable it to acquire iron from the host environment. The pathogen also possesses a system for transporting iron across its cell membrane.

In addition to horses, Taylorella equigenitalis can also infect other animals, such as donkeys and zebras. However, these animals are not considered to be significant reservoirs of the bacterium.

The diagnosis of Taylorella equigenitalis infection is often challenging due to the bacterium's fastidious nature and its slow growth in culture. The gold standard for diagnostic testing is bacterial culture, which is highly specific but requires a long incubation period. PCR-based diagnostic testing has become increasingly popular in recent years due to its high sensitivity and specificity.

PCR-based methods targeting the bacterium's 16S rRNA gene and other genes such as flaA and lipL32 have been developed and validated for detection of Taylorella equigenitalis. Serology tests can also be used to detect specific antibodies against the bacterium. These diagnostic methods have significantly contributed to the identification and management of Taylorella equigenitalis infection.

In conclusion, Taylorella equigenitalis is a gram-negative bacterium that primarily infects horses and causes a debilitating reproductive disease known as contagious equine metritis (CEM). The pathogen's virulence factors, such as adhesins, flagella, LPS, and iron transporters, contribute to its pathogenicity. Diagnostic methods, including bacterial culture and nucleic acid-based methods, have been developed and validated for the detection of Taylorella equigenitalis infection.

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