Mycoplasma avium antibody and antigen (recombinant protein)

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Diagnostic anti-Mycoplasma avium antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P157-Tg001-Ag01	Recombinant Mycoplasma avium protein	$3090.00
GMP-VT-P157-Tg001-Ab01	Anti-Mycoplasma avium mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P157-Tg001-Ab02	Anti-Mycoplasma avium mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P157-Tg001-Ab03	Anti-Mycoplasma avium human monoclonal antibody (mAb)	$3090.00
GMP-VT-P157-Tg001-Ab04	Anti-Mycoplasma avium human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P157-Tg001-Ag01
Product Name	Recombinant Mycoplasma avium protein
Pathogen	Mycoplasma avium
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Mycoplasma avium antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Mycoplasma avium level test of animal Avian/Bird/Poultry infectious disease.
Tag	His
Product description	Recombinant Mycoplasma avium proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P157-Tg001-Ab01,GMP-VT-P157-Tg001-Ab02
Pathogen	Mycoplasma avium
Product Name	Anti-Mycoplasma avium mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Mycoplasma avium antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma avium antibodies in Mycoplasma avium level test of animal Avian/Bird/Poultry infectious disease.
Product description	Anti-Mycoplasma avium mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma avium antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P157-Tg001-Ab03,GMP-VT-P157-Tg001-Ab04
Pathogen	Mycoplasma avium
Product Name	Anti-Mycoplasma avium human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Mycoplasma avium antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma avium antibodies in Mycoplasma avium level test of animal Avian/Bird/Poultry infectious disease.
Product description	Anti-Mycoplasma avium mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Mycoplasma avium is a pathogenic bacterium that can cause respiratory diseases in birds, particularly domesticated poultry. This bacterium belongs to the class Mollicutes and lacks a cell wall, which contributes to its unique biology and virulence. Its small genome size and ability to adhere to host cells using adhesin proteins enable it to evade host immune responses and colonize various tissues. In this article, we will explore more details about Mycoplasma avium including its pathogenesis, hosts, symptoms, diagnosis, and management.

Pathogenesis:

Mycoplasma avium's pathogenesis involves several factors, including its adhesion to host tissues, cytotoxicity, and immune evasion strategies. The bacterium attaches to host respiratory epithelial cells using PvpA adhesin protein, initiating colonization and immune responses. Additionally, the bacterium produces various cytotoxic factors, including hydrogen peroxide, that damage host tissues and impair local immune responses. Furthermore, it suppresses complement system activation, phagocytosis, and cytokine production to evade host immune responses.

Hosts:

Mycoplasma avium can infect various bird species, including chickens, turkeys, geese, ducks, and others. Among these, commercial broiler and layer chickens are highly susceptible to Mycoplasma avium infections. The bacterium can spread among birds through direct contact, aerosols, and contaminated fomites.

Symptoms:

Mycoplasma avium infections can cause various respiratory conditions in birds, depending on the bacterial strain, host susceptibility, and environmental factors. Common symptoms include coughing, sneezing, nasal discharge, conjunctivitis, tracheitis, airsacculitis, and other pulmonary infections. Infected birds may also exhibit lethargy, reduced feed intake, weight loss, poor egg quality or quantity, and increased mortality rates.

Diagnosis:

Diagnostic methods for Mycoplasma avium include serological testing, PCR, DNA hybridization assays, ELISA, and agar gel immunodiffusion tests. Serological tests detect specific antibodies against Mycoplasma avium in serum samples obtained from infected birds. PCR and DNA hybridization assays detect the presence of bacterial DNA or RNA in affected tissues or swabs. ELISA and agar gel immunodiffusion tests detect antibodies produced by infected birds after a few weeks of infection.

Management:

Mycoplasma avium infections can cause significant economic losses to commercial poultry producers due to reduced production outcomes and treatment costs. Control measures depend on the severity and distribution of the infections, including vaccination, biosecurity, hygiene practices, and antibiotics. Vaccination against Mycoplasma avium can reduce clinical symptoms, mortality, and transmission rates. Biosecurity measures involve minimizing interactions between infected and susceptible birds, limiting access of wild birds or rodents to the farm, and disinfecting equipment and facilities regularly. Hygiene practices include proper litter management, ventilation, and water quality. Antibiotics can be used to treat acute infections or as a prophylactic measure, but their use must be judicious to avoid antimicrobial resistance and residues in poultry products.

In conclusion, Mycoplasma avium is a pathogenic bacterium that causes respiratory diseases in birds, particularly domesticated poultry. Its unique biology, virulence factors, and immune evasion strategies contribute to its pathogenesis and impact on the poultry industry. Early diagnosis and control measures, such as vaccination, biosecurity, hygiene practices, and antibiotics administration, can reduce the economic losses and welfare implications associated with this infection.

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