Turkey Astrovirus Capsid Protein antibody and antigen (recombinant protein)

Diagnostic anti-Turkey Astrovirus Capsid Protein antibodies pairs and antigen for animal health (animal Turkey infectious disease gastroenteritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P222-Tg001-Ag01 Recombinant Turkey Astrovirus Capsid Protein protein $3090.00
GMP-VT-P222-Tg001-Ab01 Anti-Turkey Astrovirus Capsid Protein mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P222-Tg001-Ab02 Anti-Turkey Astrovirus Capsid Protein mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P222-Tg001-Ab03 Anti-Turkey Astrovirus Capsid Protein human monoclonal antibody (mAb) $3090.00
GMP-VT-P222-Tg001-Ab04 Anti-Turkey Astrovirus Capsid Protein human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P222-Tg001-Ag01
Product Name Recombinant Turkey Astrovirus Capsid Protein protein
Pathogen Turkey Astrovirus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Turkey Astrovirus Capsid Protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Turkey Astrovirus level test of animal Turkey infectious disease with gastroenteritis.
Tag His
Product description Recombinant Turkey Astrovirus Capsid Protein proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P222-Tg001-Ab01,GMP-VT-P222-Tg001-Ab02
Pathogen Turkey Astrovirus
Product Name Anti-Turkey Astrovirus Capsid Protein mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Turkey Astrovirus Capsid Protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Turkey Astrovirus antibodies in Turkey Astrovirus level test of animal Turkey infectious disease with gastroenteritis.
Product description Anti-Turkey Astrovirus Capsid Protein mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Turkey Astrovirus antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P222-Tg001-Ab03,GMP-VT-P222-Tg001-Ab04
Pathogen Turkey Astrovirus
Product Name Anti-Turkey Astrovirus Capsid Protein human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Turkey Astrovirus Capsid Protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Turkey Astrovirus antibodies in Turkey Astrovirus level test of animal Turkey infectious disease with gastroenteritis.
Product description Anti-Turkey Astrovirus Capsid Protein mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen Information


    Turkey Astrovirus (TAstV): Unveiling an Avian Pathogen

    Introduction

    Turkey Astrovirus (TAstV), a member of the Astroviridae family, is a noteworthy avian pathogen with a predilection for domestic turkeys (Meleagris gallopavo). Characterized by its single-stranded, positive-sense RNA genome and non-enveloped, icosahedral capsid structure, TAstV has been a subject of growing interest among virologists and poultry health experts. This comprehensive review aims to elucidate the classification, structure, host specificity, associated diseases, and diagnostic methods related to the Turkey Astrovirus.

    Classification and Taxonomy

    Taxonomically, Turkey Astrovirus is classified as a virus within the family Astroviridae. Within this family, it is categorized under the genus Avastrovirus. The Astroviridae family is known for non-enveloped viruses with icosahedral capsids. These viruses, including Turkey Astrovirus, are characterized by a single-stranded, positive-sense RNA genome.

    Structural Components

    The structural integrity of Turkey Astrovirus is primarily upheld by the capsid protein, a vital structural component. The capsid protein plays a pivotal role in safeguarding the viral genome and facilitating its attachment to host cells. This attachment specificity is a key factor in the virus's host range and pathogenicity. The capsid protein is known to exhibit variation across different astrovirus strains, contributing to the diversity of TAstV.

    Host Specificity

    Turkey Astrovirus is known to exclusively infect domestic turkeys and related avian species, including pheasants and chickens. The virus displays a high degree of host specificity, with limited cross-species transmission. This specificity is primarily due to the interaction between the virus's capsid protein and host cell receptors. The exact mechanisms of this interaction remain an area of ongoing research.

    Associated Diseases

    In turkeys, Turkey Astrovirus infections are associated with a range of clinical conditions. The most commonly observed manifestation is enteric disease, which can result in significant economic losses in the poultry industry. Infected turkeys often present with symptoms such as diarrhea, reduced growth rates, and, in severe cases, increased mortality, particularly among young birds. The exact pathogenesis of TAstV-induced enteric diseases is multifactorial, involving viral replication within the gastrointestinal tract and the host's immune response.

    Diagnostic Methods

    The accurate and timely diagnosis of Turkey Astrovirus infections is crucial for the management and control of the disease in poultry flocks. Various diagnostic methods have been developed, with a focus on nucleic acid-based techniques:

    Reverse Transcription-Polymerase Chain Reaction (RT-PCR): RT-PCR is a widely employed method for the detection and identification of Turkey Astrovirus. This molecular technique involves the extraction of viral RNA from clinical samples (e.g., feces, intestinal tissues) and the subsequent amplification of specific viral genomic segments. One commonly targeted region for RT-PCR is the gene encoding the capsid protein.

    Target Genes/Proteins: The specific genes or proteins targeted for diagnostic purposes may vary slightly depending on the assay. However, a common approach involves the amplification of conserved regions within the viral genome. As previously mentioned, the capsid protein gene is frequently used due to its role in viral structure and its relative stability across TAstV strains.

    Conclusion

    In conclusion, Turkey Astrovirus, or TAstV, is a notable pathogen in the avian world, with specific relevance to domestic turkeys. Its classification as a member of the Astroviridae family and the genus Avastrovirus sets it apart within the virological landscape. The virus's reliance on the capsid protein for structure and host cell attachment underscores the importance of this protein in host specificity. Turkey Astrovirus primarily causes enteric diseases in its avian hosts, with potentially severe consequences for the poultry industry.

    Diagnostic methods, particularly nucleic acid-based techniques like RT-PCR, have been pivotal in the identification and monitoring of TAstV infections. The ongoing research into Turkey Astrovirus promises to shed more light on its genetic diversity, pathogenesis, and the development of improved diagnostic tools and control strategies.

    This detailed exploration of Turkey Astrovirus provides a comprehensive understanding of this avian pathogen, which can be valuable for researchers, veterinarians, and stakeholders in the poultry industry.



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