Anaplasma phagocytophilium MSP5 antibody and antigen (recombinant protein)
Diagnostic anti-Anaplasma phagocytophilium MSP5 antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease Anaplasmosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-VT-P254-Tg001-Ag01 | Recombinant Anaplasma phagocytophilium MSP5 protein | $3090.00 |
GMP-VT-P254-Tg001-Ab01 | Anti-Anaplasma phagocytophilium MSP5 mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P254-Tg001-Ab02 | Anti-Anaplasma phagocytophilium MSP5 mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P254-Tg001-Ab03 | Anti-Anaplasma phagocytophilium MSP5 human monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P254-Tg001-Ab04 | Anti-Anaplasma phagocytophilium MSP5 human monoclonal antibody (mAb) | $3090.00 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. | GMP-VT-P254-Tg001-Ag01 |
Product Name | Recombinant Anaplasma phagocytophilium MSP5 protein |
Pathogen | Anaplasma phagocytophilium |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Anti-Anaplasma phagocytophilium MSP5 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Anaplasma phagocytophilium level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with Anaplasmosis. |
Tag | His | Product description | Recombinant Anaplasma phagocytophilium MSP5 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P254-Tg001-Ab01,GMP-VT-P254-Tg001-Ab02 |
Pathogen | Anaplasma phagocytophilium |
Product Name | Anti-Anaplasma phagocytophilium MSP5 mouse monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Recombinant Anaplasma phagocytophilium MSP5 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Anaplasma phagocytophilium antibodies in Anaplasma phagocytophilium level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with Anaplasmosis. |
Product description | Anti-Anaplasma phagocytophilium MSP5 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Anaplasma phagocytophilium antibodies. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P254-Tg001-Ab03,GMP-VT-P254-Tg001-Ab04 |
Pathogen | Anaplasma phagocytophilium |
Product Name | Anti-Anaplasma phagocytophilium MSP5 human monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Human lgG1 |
Bioactivity validation | Recombinant Anaplasma phagocytophilium MSP5 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Anaplasma phagocytophilium antibodies in Anaplasma phagocytophilium level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with Anaplasmosis. |
Product description | Anti-Anaplasma phagocytophilium MSP5 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
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Pathogen Information
Anaplasma phagocytophilium is a Gram-negative, obligate intracellular bacterium that belongs to the family Anaplasmataceae. This pathogen has a broad host range and primarily infects humans, dogs, horses, sheep, goats, cattle, and deer. Infection with Anaplasma phagocytophilium is associated with a range of clinical symptoms, including fever, headache, muscle aches, and fatigue. In humans, it causes human granulocytic anaplasmosis (HGA), while in dogs and horses, it causes canine and equine granulocytic anaplasmosis, respectively. In ruminants, it causes tick-borne fever.
The structure of Anaplasma phagocytophilium is characterized by an outer membrane that contains many complex glycolipids, lipoproteins, and outer membrane proteins. Particularly notable is its 16S ribosomal RNA gene, which is widely used for species identification and detection by Polymerase Chain Reaction (PCR). A recent study by Rar et al. (2021) found that Anaplasma phagocytophilium is highly genetically diverse, with several distinct clades circulating among different host species and geographic regions.
Anaplasma phagocytophilium has a genome that contains several genes and proteins, including those for adhesins, outer membrane proteins, immunoglobulin-binding protein, and heat shock proteins. These proteins play essential roles in pathogenesis and host immune evasion. For example, outer membrane proteins (OMPs) are involved in adhesion, invasion, and multiplication within host cells. Immunoglobulin-binding protein (Ibp) is a crucial virulence factor that enables Anaplasma phagocytophilium to evade host immune response. Heat shock proteins (HSPs) are essential for the survival of Anaplasma phagocytophilium within host cells and are associated with the induction of pro-inflammatory cytokines.
The diagnosis of Anaplasma phagocytophilium infection requires the use of molecular, serological, and microscopic methods. Blood tests, PCR, and serology are commonly used diagnostic methods that target specific genes or proteins, such as the 16S rRNA gene, the msp2 gene, and the MSP-4 protein. PCR-based diagnosis is widely used for Anaplasma phagocytophilium detection due to its high specificity and sensitivity. Serological methods are employed to detect antibodies against the pathogen, while microscopy can be used to visualize the bacterium in blood smears.
Antibiotic treatment is the primary method of managing Anaplasma phagocytophilium infections, with doxycycline being the most widely used drug. The duration of treatment varies depending on the severity of the infection and the patient's response to therapy. However, some studies have reported the emergence of antibiotic-resistant strains of Anaplasma phagocytophilium, highlighting the need for alternative treatment strategies. Several recent studies have focused on identifying new therapeutic targets, including the discovery of novel proteins involved in pathogenesis and immune evasion.
In conclusion, Anaplasma phagocytophilium is an important bacterial pathogen that infects a broad range of hosts and causes several diseases. Its genome contains several genes and proteins that play critical roles in pathogenicity and host immune evasion. Effective diagnosis and treatment of Anaplasma phagocytophilium infection require a comprehensive understanding of its biology and pathogenesis. Further research into the genetic diversity and virulence mechanisms of Anaplasma phagocytophilium is essential for developing targeted therapies and improving public health outcomes.
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