Trichophyton rubrum secreted protease Sub6 antibody and antigen (recombinant protein)

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Diagnostic anti-Trichophyton rubrum secreted protease Sub6 antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease athlete's foot, fungal infection of nail, jock itch, and ringworm) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P279-Tg001-Ag01	Recombinant Trichophyton rubrum secreted protease Sub6 protein	$3090.00
GMP-VT-P279-Tg001-Ab01	Anti-Trichophyton rubrum secreted protease Sub6 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P279-Tg001-Ab02	Anti-Trichophyton rubrum secreted protease Sub6 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P279-Tg001-Ab03	Anti-Trichophyton rubrum secreted protease Sub6 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P279-Tg001-Ab04	Anti-Trichophyton rubrum secreted protease Sub6 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P279-Tg001-Ag01
Product Name	Recombinant Trichophyton rubrum secreted protease Sub6 protein
Pathogen	Trichophyton rubrum
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Trichophyton rubrum secreted protease Sub6 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Trichophyton rubrum level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease with athlete's foot, fungal infection of nail, jock itch, and ringworm.
Tag	His
Product description	Recombinant Trichophyton rubrum secreted protease Sub6 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P279-Tg001-Ab01,GMP-VT-P279-Tg001-Ab02
Pathogen	Trichophyton rubrum
Product Name	Anti-Trichophyton rubrum secreted protease Sub6 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Trichophyton rubrum secreted protease Sub6 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Trichophyton rubrum antibodies in Trichophyton rubrum level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease with athlete's foot, fungal infection of nail, jock itch, and ringworm .
Product description	Anti-Trichophyton rubrum secreted protease Sub6 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Trichophyton rubrum antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P279-Tg001-Ab03,GMP-VT-P279-Tg001-Ab04
Pathogen	Trichophyton rubrum
Product Name	Anti-Trichophyton rubrum secreted protease Sub6 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Trichophyton rubrum secreted protease Sub6 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Trichophyton rubrum antibodies in Trichophyton rubrum level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Swine/Porcine/Pig infectious disease with athlete's foot, fungal infection of nail, jock itch, and ringworm .
Product description	Anti-Trichophyton rubrum secreted protease Sub6 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Taxonomy and Classification:

Trichophyton rubrum, a member of the Dermatophytes group, belongs to the Trichophyton genus within the Arthrodermataceae family. This filamentous fungus is classified within the phylum Ascomycota. Within its genus, it stands out as a clinically significant species responsible for a range of dermatophytosis infections in humans.

Morphology:

Microscopically, Trichophyton rubrum exhibits septate hyphae, characterized by segmented structures with cross-walls. Conidiophores, specialized structures that bear conidia, play a crucial role in the fungus's reproductive cycle. The conidia themselves are typically smooth-walled and microconidia are more abundant than macroconidia. The unique morphological features of this dermatophyte contribute to its pathogenicity and ability to colonize keratinized tissues.

Pathogenic Mechanisms:

Trichophyton rubrum is equipped with an arsenal of enzymes, including keratinases and chitinases. These enzymes are pivotal for the breakdown of keratin, the tough and fibrous protein found in skin, hair, and nails. The ability to degrade keratin allows the fungus to establish infections in these tissues. Additionally, adhesion factors and proteases facilitate the adherence of the pathogen to host cells and the evasion of the host immune response.

Host Interactions:

Trichophyton rubrum primarily infects humans, establishing a commensal relationship with the keratinized tissues of the skin, hair, and nails. Factors such as compromised immunity, warm and humid environments, and poor hygiene can contribute to increased susceptibility to infection. The fungus thrives in conditions conducive to its growth, making it a common cause of dermatophytosis worldwide.

Associated Diseases:

The spectrum of diseases caused by Trichophyton rubrum is collectively referred to as dermatophytosis. These infections manifest in various forms:

Tinea Pedis (Athlete's Foot): Affecting the feet, particularly the interdigital spaces, this condition is characterized by erythematous, scaly lesions and is often associated with itching.

Tinea Cruris (Jock Itch): Predominantly occurring in the groin and perineal regions, this infection presents as a red, itchy rash with well-defined borders.

Tinea Corporis (Ringworm): This dermatophytosis affects non-hairy skin, causing circular, red lesions with raised borders.

Tinea Unguium (Onychomycosis): Involving the nails, this infection results in thickened, discolored, and brittle nails.

Diagnostic Methodologies:

Accurate diagnosis is essential for effective management of Trichophyton rubrum infections. Traditional culture-based methods involve obtaining clinical samples, such as skin scrapings or nail clippings, and cultivating them on specialized media. The characteristic growth of the fungus aids identification.

In recent years, molecular diagnostic methods have gained prominence. Polymerase Chain Reaction (PCR) targeting specific genetic regions, such as the Internal Transcribed Spacer (ITS) region and the 28S rRNA gene, allows for rapid and precise identification. DNA sequencing further enhances the discriminatory power of these techniques.

Treatment Strategies:

Management of Trichophyton rubrum infections often involves topical or systemic antifungal agents. Topical treatments, including azoles and allylamines, are effective for mild to moderate cases. Systemic therapy becomes necessary for severe or persistent infections and typically involves oral antifungal medications such as terbinafine or itraconazole. The duration of treatment varies depending on the type and severity of the infection.

In conclusion, Trichophyton rubrum stands as a clinically relevant dermatophyte, intricately adapted to exploit keratinized tissues in humans. Understanding its taxonomy, morphology, pathogenic mechanisms, host interactions, associated diseases, diagnostic methodologies, and treatment strategies is crucial for effective clinical management and underscores the need for ongoing research to advance our knowledge of this fungal pathogen.

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