Products
Pascolizumab Biosimilar Monoclonal Antibody (IL-4) for Research
Anti-IL4 therapeutic antibody (Pre-made Pascolizumab biosimilar, Whole mAb) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Pascolizumab is a humanized monoclonal antibody for the treatment of asthma.[1] A Phase II clinical trial in patients with symptomatic glucocorticoid naive asthma has been conducted in 21/22.[2]
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-945-1mg | 1mg | 3090 |
| GMP-Bios-INN-945-10mg | 10mg | |
| GMP-Bios-INN-945-100mg | 100mg | |
| GMP-Bios-INN-945-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Pascolizumab Biosimilar, Whole Mab, Anti-Il4 Antibody: Anti-BCGF-1/BCGF1/BSF-1/BSF1/IL-4 therapeutic antibody |
| INN Name | Pascolizumab |
| Target | IL4 |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | human |
| CH1 Isotype | IgG1 - kappa |
| VD LC | IgG1 - kappa |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | Centocor Inc. (Horsham PA USA) / GlaxoSmithKline (Brentford UK) |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | 0 |
About target - IL4
1. Protein Interleukin-4
2. Gene IL4
3. Organism Homo sapiens (Human)
Function
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727).
It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).
Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).
