Recombinant multi-species CP3A4/ CYP3A4/ CP33 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP3A4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CYP3A4, gene name: CYP3A4, also named as CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-IP0038-Ag-1	Human CYP3A4 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-IP0038-Ag-1	Rat CYP3A4 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-IP0038-Ag-1	Mouse CYP3A4 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-IP0038-Ag-1	Cynomolgus/ Rhesus macaque CYP3A4 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-IP0038-Ag-1	Feline CYP3A4 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-IP0038-Ag-1	Canine CYP3A4 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-IP0038-Ag-1	Bovine CYP3A4 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-IP0038-Ag-1	Equine CYP3A4 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-IP0038-Ag, GM-Tg-rg-IP0038-Ag, GM-Tg-mg-IP0038-Ag, GM-Tg-cynog-IP0038-Ag, GM-Tg-felg-IP0038-Ag, GM-Tg-cang-IP0038-Ag, GM-Tg-bovg-IP0038-Ag, GM-Tg-equg-IP0038-Ag-1
Products Name	CYP3A4 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CYP3A4
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CYP3A4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.