Recombinant multi-species ANDR/ AR/ AIS8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: AR, gene name: AR, also named as AIS8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, AR. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T11211-Ag-1	Human AR protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T11211-Ag-1	Rat AR protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T11211-Ag-1	Mouse AR protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T11211-Ag-1	Cynomolgus/ Rhesus macaque AR protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T11211-Ag-1	Feline AR protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T11211-Ag-1	Canine AR protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T11211-Ag-1	Bovine AR protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T11211-Ag-1	Equine AR protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T11211-Ag, GM-Tg-rg-T11211-Ag, GM-Tg-mg-T11211-Ag, GM-Tg-cynog-T11211-Ag, GM-Tg-felg-T11211-Ag, GM-Tg-cang-T11211-Ag, GM-Tg-bovg-T11211-Ag, GM-Tg-equg-T11211-Ag-1
Products Name	AR protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	AR
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.