Recombinant multi-species ROCK1/ P160ROCK/ ROCK-I protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ROCK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: ROCK1, gene name: ROCK1, also named as P160ROCK, ROCK-I. This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T51282-Ag-1	Human ROCK1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T51282-Ag-1	Rat ROCK1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T51282-Ag-1	Mouse ROCK1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T51282-Ag-1	Cynomolgus/ Rhesus macaque ROCK1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T51282-Ag-1	Feline ROCK1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T51282-Ag-1	Canine ROCK1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T51282-Ag-1	Bovine ROCK1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T51282-Ag-1	Equine ROCK1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T51282-Ag, GM-Tg-rg-T51282-Ag, GM-Tg-mg-T51282-Ag, GM-Tg-cynog-T51282-Ag, GM-Tg-felg-T51282-Ag, GM-Tg-cang-T51282-Ag, GM-Tg-bovg-T51282-Ag, GM-Tg-equg-T51282-Ag-1
Products Name	ROCK1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	ROCK1
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ROCK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.