Recombinant multi-species NR1H3/ LXR-a/ LXRA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1H3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: NR1H3, gene name: NR1H3, also named as LXR-a, LXRA, RLD-1. The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T52297-Ag-1Human NR1H3 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T52297-Ag-1Rat NR1H3 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T52297-Ag-1Mouse NR1H3 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T52297-Ag-1Cynomolgus/ Rhesus macaque NR1H3 proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T52297-Ag-1Feline NR1H3 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T52297-Ag-1Canine NR1H3 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T52297-Ag-1Bovine NR1H3 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T52297-Ag-1Equine NR1H3 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T52297-Ag, GM-Tg-rg-T52297-Ag, GM-Tg-mg-T52297-Ag, GM-Tg-cynog-T52297-Ag,
GM-Tg-felg-T52297-Ag, GM-Tg-cang-T52297-Ag, GM-Tg-bovg-T52297-Ag, GM-Tg-equg-T52297-Ag-1
Products Name NR1H3 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameNR1H3
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1H3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.