Recombinant multi-species CO5/ C5/ C5Da protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CO5/C5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CO5, gene name: C5, also named as C5Da, C5b, CPAMD4, ECLZB, C5. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T60708-Ag-1	Human CO5/C5 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T60708-Ag-1	Rat CO5/C5 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T60708-Ag-1	Mouse CO5/C5 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T60708-Ag-1	Cynomolgus/ Rhesus macaque CO5/C5 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T60708-Ag-1	Feline CO5/C5 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T60708-Ag-1	Canine CO5/C5 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T60708-Ag-1	Bovine CO5/C5 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T60708-Ag-1	Equine CO5/C5 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T60708-Ag, GM-Tg-rg-T60708-Ag, GM-Tg-mg-T60708-Ag, GM-Tg-cynog-T60708-Ag, GM-Tg-felg-T60708-Ag, GM-Tg-cang-T60708-Ag, GM-Tg-bovg-T60708-Ag, GM-Tg-equg-T60708-Ag-1
Products Name	CO5/C5 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CO5
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CO5/C5 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.