Recombinant multi-species P53/ TP53 Y220C/ TP53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TP53 Y220C/TP53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: TP53 Y220C, gene name: TP53, also named as BCC7, LFS1, P53, TRP53. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T69823-Ag-1	Human TP53 Y220C/TP53 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T69823-Ag-1	Rat TP53 Y220C/TP53 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T69823-Ag-1	Mouse TP53 Y220C/TP53 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T69823-Ag-1	Cynomolgus/ Rhesus macaque TP53 Y220C/TP53 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T69823-Ag-1	Feline TP53 Y220C/TP53 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T69823-Ag-1	Canine TP53 Y220C/TP53 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T69823-Ag-1	Bovine TP53 Y220C/TP53 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T69823-Ag-1	Equine TP53 Y220C/TP53 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T69823-Ag, GM-Tg-rg-T69823-Ag, GM-Tg-mg-T69823-Ag, GM-Tg-cynog-T69823-Ag, GM-Tg-felg-T69823-Ag, GM-Tg-cang-T69823-Ag, GM-Tg-bovg-T69823-Ag, GM-Tg-equg-T69823-Ag-1
Products Name	TP53 Y220C/TP53 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	TP53 Y220C
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TP53 Y220C/TP53 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.