Recombinant multi-species GDNF/ ATF/ ATF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GDNF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: GDNF, gene name: GDNF, also named as ATF, ATF1, ATF2, HFB1-GDNF, HSCR3. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T79160-Ag-1	Human GDNF protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T79160-Ag-1	Rat GDNF protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T79160-Ag-1	Mouse GDNF protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T79160-Ag-1	Cynomolgus/ Rhesus macaque GDNF protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T79160-Ag-1	Feline GDNF protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T79160-Ag-1	Canine GDNF protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T79160-Ag-1	Bovine GDNF protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T79160-Ag-1	Equine GDNF protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T79160-Ag, GM-Tg-rg-T79160-Ag, GM-Tg-mg-T79160-Ag, GM-Tg-cynog-T79160-Ag, GM-Tg-felg-T79160-Ag, GM-Tg-cang-T79160-Ag, GM-Tg-bovg-T79160-Ag, GM-Tg-equg-T79160-Ag-1
Products Name	GDNF protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	GDNF
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GDNF protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.