Anti-NCHL1/ CHL1/ CALL monoclonal antibody

Anti-NCHL1/ CHL1/ CALL antibody for FACS & in-vivo assay

Target products collectionGo to CHL1/CHL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0259-Ab-1/ GM-Tg-hg-MP0259-Ab-2Anti-Human CHL1 monoclonal antibodyHuman
GM-Tg-rg-MP0259-Ab-1/ GM-Tg-rg-MP0259-Ab-2Anti-Rat CHL1 monoclonal antibodyRat
GM-Tg-mg-MP0259-Ab-1/ GM-Tg-mg-MP0259-Ab-2Anti-Mouse CHL1 monoclonal antibodyMouse
GM-Tg-cynog-MP0259-Ab-1/ GM-Tg-cynog-MP0259-Ab-2Anti-Cynomolgus/ Rhesus macaque CHL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0259-Ab-1/ GM-Tg-felg-MP0259-Ab-2Anti-Feline CHL1 monoclonal antibodyFeline
GM-Tg-cang-MP0259-Ab-1/ GM-Tg-cang-MP0259-Ab-2Anti-Canine CHL1 monoclonal antibodyCanine
GM-Tg-bovg-MP0259-Ab-1/ GM-Tg-bovg-MP0259-Ab-2Anti-Bovine CHL1 monoclonal antibodyBovine
GM-Tg-equg-MP0259-Ab-1/ GM-Tg-equg-MP0259-Ab-2Anti-Equine CHL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0259-Ab-1/ GM-Tg-hg-MP0259-Ab-2; GM-Tg-rg-MP0259-Ab-1/ GM-Tg-rg-MP0259-Ab-2;
GM-Tg-mg-MP0259-Ab-1/ GM-Tg-mg-MP0259-Ab-2; GM-Tg-cynog-MP0259-Ab-1/ GM-Tg-cynog-MP0259-Ab-2;
GM-Tg-felg-MP0259-Ab-1/ GM-Tg-felg-MP0259-Ab-2; GM-Tg-cang-MP0259-Ab-1/ GM-Tg-cang-MP0259-Ab-2;
GM-Tg-bovg-MP0259-Ab-1/ GM-Tg-bovg-MP0259-Ab-2; GM-Tg-equg-MP0259-Ab-1/ GM-Tg-equg-MP0259-Ab-2
Products NameAnti-CHL1 monoclonal antibody
Formatmab
Target NameCHL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CHL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NCHL1/ CHL1/ CALL VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0259
    Target NameCHL1
    Gene ID10752,12661,89828,709172,476554,101095560,504415,100061158
    Gene Symbol and SynonymsA530023M13Rik,CALL,CHL1,L1CAM2,LICAM2
    Uniprot AccessionO00533
    Uniprot Entry NameNCHL1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseMucocutaneous lymph node syndrome [Kawasaki]
    Gene EnsemblENSG00000134121
    Target ClassificationN/A

    The target: CHL1, gene name: CHL1, also named as CALL, L1CAM2. The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.