Anti-SHH/ HHG1/ HLP3 monoclonal antibody
Anti-SHH/ HHG1/ HLP3 antibody for FACS & in-vivo assay
Go to SHH/SHH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T12075-Ab-1/ GM-Tg-hg-T12075-Ab-2 | Anti-Human SHH monoclonal antibody | Human |
GM-Tg-rg-T12075-Ab-1/ GM-Tg-rg-T12075-Ab-2 | Anti-Rat SHH monoclonal antibody | Rat |
GM-Tg-mg-T12075-Ab-1/ GM-Tg-mg-T12075-Ab-2 | Anti-Mouse SHH monoclonal antibody | Mouse |
GM-Tg-cynog-T12075-Ab-1/ GM-Tg-cynog-T12075-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SHH monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T12075-Ab-1/ GM-Tg-felg-T12075-Ab-2 | Anti-Feline SHH monoclonal antibody | Feline |
GM-Tg-cang-T12075-Ab-1/ GM-Tg-cang-T12075-Ab-2 | Anti-Canine SHH monoclonal antibody | Canine |
GM-Tg-bovg-T12075-Ab-1/ GM-Tg-bovg-T12075-Ab-2 | Anti-Bovine SHH monoclonal antibody | Bovine |
GM-Tg-equg-T12075-Ab-1/ GM-Tg-equg-T12075-Ab-2 | Anti-Equine SHH monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T12075-Ab-1/ GM-Tg-hg-T12075-Ab-2; GM-Tg-rg-T12075-Ab-1/ GM-Tg-rg-T12075-Ab-2; GM-Tg-mg-T12075-Ab-1/ GM-Tg-mg-T12075-Ab-2; GM-Tg-cynog-T12075-Ab-1/ GM-Tg-cynog-T12075-Ab-2; GM-Tg-felg-T12075-Ab-1/ GM-Tg-felg-T12075-Ab-2; GM-Tg-cang-T12075-Ab-1/ GM-Tg-cang-T12075-Ab-2; GM-Tg-bovg-T12075-Ab-1/ GM-Tg-bovg-T12075-Ab-2; GM-Tg-equg-T12075-Ab-1/ GM-Tg-equg-T12075-Ab-2 |
Products Name | Anti-SHH monoclonal antibody |
Format | mab |
Target Name | SHH |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SHH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species SHH/ HHG1/ HLP3 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMAAV000001 | human SHH AAV plasmid |
ORF Viral Vector | vGMAAV000001 | human SHH AAV particle |
Target information
Target ID | GM-T12075 |
Target Name | SHH |
Gene ID | 6469,20423,29499,716553,608860,111557492,286821,100147450 |
Gene Symbol and Synonyms | 9530036O11Rik,Dsh,HHG1,HLP3,HPE3,Hx,Hxl3,M100081,MCOPCB5,SHH,ShhNC,SMMCI,TPT,TPTPS |
Uniprot Accession | Q15465,Q63673 |
Uniprot Entry Name | SHH_HUMAN,SHH_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000164690 |
Target Classification | N/A |
The target: SHH, gene name: SHH, also named as HHG1, HLP3, HPE3, MCOPCB5, SMMCI, ShhNC, TPT, TPTPS. This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.