Pancreatic elastase (PE-1) antibody and antigen (recombinant protein)

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Diagnostic anti-Pancreatic elastase (PE-1) antibodies pairs and antigen for animal health (animal Dog/Canine Canine pancreatitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-Pancreatic-elastase-Ag01	Pancreatic elastase (PE-1)	$3090.00
GMP-CAN-Pancreatic-elastase-Ab01	Anti-Pancreatic elastase (PE-1) mouse monoclonal antibody (mAb)	$3090.00
GMP-CAN-Pancreatic-elastase-Ab02	Anti-Pancreatic elastase (PE-1) mouse monoclonal antibody (mAb)	$3090.00
GMP-CAN-Pancreatic-elastase-Ab03	Anti-Pancreatic elastase (PE-1) human monoclonal antibody (mAb)	$3090.00
GMP-CAN-Pancreatic-elastase-Ab04	Anti-Pancreatic elastase (PE-1) human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-CAN-Pancreatic-elastase-Ag01
Product Name	Pancreatic elastase (PE-1)
Target/Biomarker	not infectious
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Pancreatic elastase (PE-1) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Pancreatic elastase (PE-1) level test of animal Dog/Canine with Canine pancreatitis.
Tag	His
Reconized/Reactive Specics	Pancreatic elastase (PE-1)
Product description	Recombinant Pancreatic elastase (PE-1) protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-CAN-Pancreatic-elastase-Ab01,GMP-CAN-Pancreatic-elastase-Ab02
Target/Biomarker	not infectious
Product Name	Anti-Pancreatic elastase (PE-1) mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Pancreatic elastase (PE-1) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pancreatic elastase (PE-1) antibodies in Pancreatic elastase (PE-1) level test of animal Dog/Canine with Canine pancreatitis.
Product description	Anti-Pancreatic elastase (PE-1) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pancreatic elastase (PE-1) antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-CAN-Pancreatic-elastase-Ab03,GMP-CAN-Pancreatic-elastase-Ab04
Target/Biomarker	not infectious
Product Name	Anti-Pancreatic elastase (PE-1) human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Pancreatic elastase (PE-1) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pancreatic elastase (PE-1) antibodies in Pancreatic elastase (PE-1) level test of animal Dog/Canine with Canine pancreatitis.
Product description	Anti-Pancreatic elastase (PE-1) mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker Information

The measurement of Pancreatic Elastase levels serves as a linchpin in the practice of modern medicine and gastroenterology, affording critical insights into pancreatic health, gastrointestinal function, and overall well-being.

Pancreatic exocrine insufficiency (PEI), a condition characterized by the inadequate production and secretion of digestive enzymes, is a notable area where pancreatic elastase measurement shines. PEI manifests as impaired protein digestion and malabsorption of nutrients, leading to weight loss, nutrient deficiencies, and gastrointestinal distress. The measurement of pancreatic elastase provides a precise, non-invasive means to diagnose PEI, facilitating early intervention.

In clinical practice, the assessment of pancreatic elastase levels is foundational for tailoring treatment strategies. Individuals and animals diagnosed with PEI often require enzyme replacement therapy to restore proper digestion and nutrient absorption. Regular monitoring of pancreatic elastase levels enables healthcare providers and veterinarians to adjust therapy to meet the unique needs of each patient, optimizing their nutritional status and overall health.

Beyond PEI, pancreatic elastase measurement has broader clinical applications. It can aid in the evaluation of pancreatic function in individuals and animals with suspected or known pancreatic disorders, such as chronic pancreatitis. By assessing elastase levels, healthcare providers can gauge the severity of pancreatic dysfunction and guide treatment decisions.

In the realm of research, pancreatic elastase measurement fuels exploration into pancreatic physiology and its intricate role in gastrointestinal health. Researchers can delve into the factors influencing enzyme production, delve into potential therapeutic targets, and pioneer innovative approaches to enhance pancreatic exocrine function. This body of knowledge has the potential to transform our understanding of digestive diseases and inform the development of novel interventions.

Moreover, pancreatic elastase measurement holds promise in the study of cystic fibrosis, a genetic disorder characterized by abnormally thick mucus production that can block pancreatic ducts, leading to impaired enzyme secretion and digestive issues. Monitoring pancreatic elastase levels can help assess pancreatic function in individuals with cystic fibrosis and inform therapeutic decisions.

In sum, the measurement of Pancreatic Elastase is not merely a clinical tool; it is a beacon of insight into pancreatic function and digestive health. Its diagnostic and monitoring capabilities are instrumental in identifying and managing conditions like PEI, while its contributions to research advance our understanding of pancreatic physiology, offering hope for innovative therapies that can enhance the well-being of individuals and animals alike., Pancreatic Elastase, an enzymatic workhorse produced by the exocrine pancreas, occupies a pivotal role in the intricate symphony of protein digestion. Structurally, it belongs to the serine protease family, characterized by a catalytic triad composed of serine, histidine, and aspartate residues. The active site of pancreatic elastase is finely tuned to cleave peptide bonds adjacent to small, hydrophobic amino acids, making it particularly suited for its primary substrate, elastin.

Elastin, a structural protein, bestows elasticity upon various connective tissues, including arteries, skin, and organs. The digestion of elastin and other proteins is catalyzed by pancreatic elastase, which cleaves these macromolecules into smaller, more manageable peptide fragments. This process is instrumental in breaking down dietary proteins into amino acids, the building blocks of life, enabling their absorption in the small intestine.

Pancreatic elastase's release into the duodenum and upper jejunum of the small intestine is meticulously regulated in response to hormonal signals, ensuring that it is deployed precisely when needed during the digestive process.

The measurement of pancreatic elastase levels offers a glimpse into the pancreas's exocrine function. A decrease in pancreatic elastase levels below the normative range signifies impaired pancreatic function and a compromised ability to digest proteins. This can lead to the malabsorption of essential nutrients and the development of clinical symptoms associated with protein deficiency.

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