Equine Haptoglobin antibody and antigen (recombinant protein)

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Diagnostic anti-Equine Haptoglobin antibodies pairs and antigen for animal health (animal Equine/Horse milk fever, ketosis, severe mastitis, acute severe metritis, retained placenta and chronic endometritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Size： 1mg | 10mg | 100mg

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Target/Biomarker Information

Equine Haptoglobin is an acute phase protein with a significant role in the inflammatory response and as a biomarker of tissue injury in horses. When a horse experiences inflammation, infection, or tissue damage, the liver is prompted to synthesize and release increased amounts of haptoglobin into the bloodstream.

The primary function of haptoglobin in the horse, as in other mammals, is to bind free hemoglobin released during intravascular hemolysis. This binding is crucial because free hemoglobin can be toxic due to its oxidative properties. The haptoglobin-hemoglobin complexes are then removed from circulation by the liver, which also helps conserve valuable iron that can be reused for erythropoiesis (the production of new red blood cells).

In the context of veterinary medicine, measuring haptoglobin levels in horses provides veterinarians with important diagnostic information. Elevated haptoglobin can indicate various conditions, including respiratory infections, systemic inflammatory response syndrome (SIRS), gastrointestinal diseases causing systemic inflammation (such as colitis or enteritis), and muscular injuries. Since haptoglobin levels can rise rapidly following the onset of an inflammatory stimulus, it is a useful indicator of acute inflammation.

Monitoring haptoglobin can also be valuable in managing equine health, particularly in the context of performance horses, where early detection of subclinical disease can prevent further injury and aid in timely treatment. For example, in equine athletes, elevated haptoglobin levels might suggest muscle damage or other inflammatory conditions that could impair performance, necessitating rest and recovery.

Furthermore, haptoglobin levels are utilized to monitor the disease progression and response to treatment in horses. A decrease in haptoglobin concentrations during recovery can signal a successful response to treatment, while persistent elevation may indicate ongoing inflammation or insufficient therapeutic intervention.

However, it's essential to interpret haptoglobin levels in conjunction with other clinical findings and laboratory tests since it is a non-specific marker. Other acute phase proteins and complete blood counts, along with clinical signs and history, contribute to a comprehensive assessment of the horse's health.

In summary, equine haptoglobin is an important protein for veterinarians to consider when evaluating the health status of horses. Its role in binding free hemoglobin protects the body from oxidative damage, and its levels in blood can serve as a sensitive biomarker for inflammation and tissue injury. This makes haptoglobin a valuable tool in diagnosing, monitoring, and managing various health conditions in horses.

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