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Description of Small molecules (Chemicals, Antibiotics,Mycotoxins,Hormones,Drugs of Abuse, etc.)

Polymyxin B is a mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.

Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line.

A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.

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Delivery impact due to the Coronavirus Outbreak

With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No. Description Price(In USD) Qty (Quantity) Sum(In USD)
GMP-SMT-70-1 1. BSA-Polymyxin B(PMB); Size:1mg
2. Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:1mg
1365
GMP-SMT-70-1 1. BSA-Polymyxin B(PMB); Size:10mg
2. Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:10mg
9555
GMP-SMT-70-1 1. BSA-Polymyxin B(PMB); Size:100mg
2. Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:100mg
66885
GMP-SMT-70-2 1. OVA-Polymyxin B(PMB); Size:1mg
2. Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:1mg
1365
GMP-SMT-70-2 1. OVA-Polymyxin B(PMB); Size:10mg
2. Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:10mg
9555
GMP-SMT-70-2 1. OVA-Polymyxin B(PMB); Size:100mg
2. Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:100mg
66885
GMP-SMT-70-Ab-1 Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:1mg 1043
GMP-SMT-70-Ab-1 Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:10mg 7301
GMP-SMT-70-Ab-1 Anti-Polymyxin B(PMB) mouse monoclonal antibody; Size:100mg 51107
GMP-SMT-70-Ag-1 BSA-Polymyxin B(PMB); Size:1mg 756
GMP-SMT-70-Ag-1 BSA-Polymyxin B(PMB); Size:10mg 5292
GMP-SMT-70-Ag-1 BSA-Polymyxin B(PMB); Size:100mg 37044
GMP-SMT-70-Ag-2 OVA-Polymyxin B(PMB); Size:1mg 756
GMP-SMT-70-Ag-2 OVA-Polymyxin B(PMB); Size:10mg 5292
GMP-SMT-70-Ag-2 OVA-Polymyxin B(PMB); Size:100mg 37044
GMP-SMT-70 ≥100mg Inquiry
Shipping Cost: 760.00
Total:



Description


BSA-Polymyxin B(PMB)

Cat No. GMP-SMT-70-Ag-1
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [BSA-Polymyxin B(PMB)]with anti-Hapten antibody. The hapten hapten-carrier conjugates [BSA-Polymyxin B(PMB)] had been validated with our anti-Hapten antibody[Anti-Polymyxin B(PMB) mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


OVA-Polymyxin B(PMB)

Cat No. GMP-SMT-70-Ag-2
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [ OVA-Polymyxin B(PMB)] with anti-Hapten antibody. The hapten hapten-carrier conjugates[ OVA-Polymyxin B(PMB)] had been validated with our anti-Hapten antibody[Anti-Polymyxin B(PMB) mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Anti-Polymyxin B(PMB) mouse monoclonal antibody

Cat No. GMP-SMT-70-Ab-1
Host of Antibody Mouse IgG
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb) 10-20
Products description The anti-Hapten antibody against hapten [Polymyxin B(PMB)] had beenvalidated with our hapten hapten-carrier conjugates [BSA-Polymyxin B(PMB)] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.