Canine Herpesvirus antibody and antigen (recombinant protein)

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Diagnostic anti-Canine Herpesvirus antibodies pairs and antigen for animal health (animal Dog/Canine infectious disease canine herpes) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P001-Tg001-Ag01	Recombinant Canine Herpesvirus protein	$3090.00
GMP-VT-P001-Tg001-Ab01	Anti-Canine Herpesvirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P001-Tg001-Ab02	Anti-Canine Herpesvirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P001-Tg001-Ab03	Anti-Canine Herpesvirus human monoclonal antibody (mAb)	$3090.00
GMP-VT-P001-Tg001-Ab04	Anti-Canine Herpesvirus human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P001-Tg001-Ag01
Product Name	Recombinant Canine Herpesvirus protein
Pathogen	Canine Herpesvirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Herpesvirus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine Herpesvirus level test of animal Dog/Canine infectious disease with canine herpes.
Tag	His
Product description	Recombinant Canine Herpesvirus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P001-Tg001-Ab01,GMP-VT-P001-Tg001-Ab02
Pathogen	Canine Herpesvirus
Product Name	Anti-Canine Herpesvirus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Herpesvirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Herpesvirus antibodies in Canine Herpesvirus level test of animal Dog/Canine infectious disease with canine herpes.
Product description	Anti-Canine Herpesvirus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Herpesvirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P001-Tg001-Ab03,GMP-VT-P001-Tg001-Ab04
Pathogen	Canine Herpesvirus
Product Name	Anti-Canine Herpesvirus human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Canine Herpesvirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Herpesvirus antibodies in Canine Herpesvirus level test of animal Dog/Canine infectious disease with canine herpes.
Product description	Anti-Canine Herpesvirus mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Canine Herpesvirus (CHV) is a highly contagious disease that affects dogs and is primarily seen in newborn puppies. This virus has been found all over the world, and it is a significant problem for breeders of purebred dogs. The virus can lead to high mortality rates, particularly in puppies under three weeks of age. In this article, we will go more in-depth on CHV, discussing its pathogen classification, structure, hosts, and diagnostic methods.

CHV is a viral infection that belongs to the family Herpesviridae, genus Varicellovirus. Like other herpesviruses, CHV is an enveloped virus with a double-stranded DNA genome enclosed within a protein capsid. CHV has a complex structure consisting of many proteins, including those involved in its viral replication, immune evasion, and host-cell interaction. These proteins help the virus evade host defenses and replicate efficiently.

Dogs of all ages are susceptible to CHV, but the virus is especially lethal in newborn puppies. It tends to spread quickly within a group of puppies, leading to systemic infections. When infected, puppies may exhibit symptoms such as lethargy, weakness, diarrhea, respiratory distress, and fever. In severe cases, CHV can cause neurological signs, such as seizures. Infected puppies can also develop pneumonia, which can lead to fatal outcomes.

Reproductive failure is another primary issue caused by CHV, which leads to infertility, abortion, stillbirth, and weak and underdeveloped puppies. It is believed that the virus can survive in the reproductive tract, making it possible for the infection to pass from the mother to the offspring.

To diagnose CHV, various testing methods are available. PCR is the most commonly used method, where specific genes within the viral DNA, such as the thymidine kinase or glycoprotein B gene, are targeted. This method requires a sample of blood, fluid, or tissue to amplify the virus' DNA and detect its presence. Another testing method is viral culture, which involves growing the virus in cell cultures. Culture-based methods can take longer than PCR but tend to be more accurate. Additionally, serology detects the presence of antibodies to CHV in the blood, targeting the viral glycoprotein G gene.

In summary, CHV is a significant problem for dog breeders and owners. This virus is highly contagious and lethal in newborn puppies. Prevention through vaccination of pregnant females is currently the most effective way to prevent CHV-associated reproductive failure. Furthermore, early and accurate diagnosis is essential for successful management of CHV infection and aiding in the implementation of proper biosecurity measures to prevent further infections within the affected population.

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