Anaplasma platys OMP-1X antibody and antigen (recombinant protein)

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Diagnostic anti-Anaplasma platys OMP-1X antibodies pairs and antigen for animal health (animal Dog/Canine infectious disease canine cyclic thrombocytopenia, or thrombocytotropic anaplasmosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P031-Tg001-Ag01	Recombinant Anaplasma platys OMP-1X protein	$3090.00
GMP-VT-P031-Tg001-Ab01	Anti-Anaplasma platys OMP-1X mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P031-Tg001-Ab02	Anti-Anaplasma platys OMP-1X mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P031-Tg001-Ab03	Anti-Anaplasma platys OMP-1X human monoclonal antibody (mAb)	$3090.00
GMP-VT-P031-Tg001-Ab04	Anti-Anaplasma platys OMP-1X human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P031-Tg001-Ag01
Product Name	Recombinant Anaplasma platys OMP-1X protein
Pathogen	Anaplasma platys
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Anaplasma platys OMP-1X antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Anaplasma platys level test of animal Dog/Canine infectious disease with canine cyclic thrombocytopenia, or thrombocytotropic anaplasmosis.
Tag	His
Product description	Recombinant Anaplasma platys OMP-1X proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P031-Tg001-Ab01,GMP-VT-P031-Tg001-Ab02
Pathogen	Anaplasma platys
Product Name	Anti-Anaplasma platys OMP-1X mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Anaplasma platys OMP-1X antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Anaplasma platys antibodies in Anaplasma platys level test of animal Dog/Canine infectious disease with canine cyclic thrombocytopenia, or thrombocytotropic anaplasmosis.
Product description	Anti-Anaplasma platys OMP-1X mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Anaplasma platys antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P031-Tg001-Ab03,GMP-VT-P031-Tg001-Ab04
Pathogen	Anaplasma platys
Product Name	Anti-Anaplasma platys OMP-1X human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Anaplasma platys OMP-1X antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Anaplasma platys antibodies in Anaplasma platys level test of animal Dog/Canine infectious disease with canine cyclic thrombocytopenia, or thrombocytotropic anaplasmosis.
Product description	Anti-Anaplasma platys OMP-1X mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Anaplasma platys, also known as Ehrlichia platys, is a gram-negative, tick-borne bacteria that belongs to the order Rickettsiales and family Anaplasmataceae. It was first identified in platelets of dogs in the 1970s and is now recognized as one of the major causes of canine vector-borne diseases worldwide.

Anaplasma platys is an obligate intracellular bacteria that infects and reproduces within host cells such as platelets, monocytes, and macrophages. The exact mechanism of transmission and pathogenesis of A. platys is not well understood, but it is believed that ticks act as the primary vector and transmit the bacteria to host animals during the feeding process. Once inside the host animal, A. platys can cause significant damage by disrupting normal host cell function and inducing immune responses.

A. platys primarily infects dogs and can cause a disease called canine cyclic thrombocytopenia (CCT). In CCT, there are periodic decreases in platelet counts, which can lead to bleeding and associated clinical signs such as fever, lethargy, anorexia, and petechiae. A. platys infection has been reported in dogs from various parts of the world, including Europe, North and South America, Africa, and Asia.

Diagnosis of A. platys infection can be challenging due to the non-specific clinical signs and the low level of bacteria in the bloodstream. However, several diagnostic methods have been developed, including serological assays and molecular-based techniques. Serological assays such as enzyme-linked immunosorbent assay (ELISA) can detect antibodies against major surface protein (MSP) antigens of A. platys. Molecular-based techniques such as polymerase chain reaction (PCR) and real-time PCR can detect the presence of A. platys DNA in blood samples, and target genes such as msp5.

Treatment of A. platys infection typically involves the use of antibiotics such as doxycycline, tetracycline, and minocycline. Treatment is generally effective but may require prolonged administration due to the intracellular nature of the bacteria. Prevention of A. platys infection in dogs involves the use of tick control measures and limiting exposure to tick-infested areas.

In conclusion, Anaplasma platys is an important tick-borne pathogen that can cause canine cyclic thrombocytopenia in dogs. Several diagnostic methods are available for detecting A. platys infection, including PCR and ELISA. Early diagnosis and treatment with antibiotics can result in positive outcomes for infected animals. Tick control and prevention measures are key to minimizing the risk of A. platys infection in dogs.

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